Lithium Attenuates Nerve Growth Factor–Induced Activation of AP-1 DNA Binding Activity in PC12 Cells

Unlap, M. Tino; Jope, Richard S.

doi:10.1016/s0893-133x(97)00020-1

Neuropsychopharmacology

1997

DOI: 10.1016/s0893-133x(97)00020-1

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Lithium Attenuates Nerve Growth Factor–Induced Activation of AP-1 DNA Binding Activity in PC12 Cells

M. Tino Unlap

Richard S. Jope

Abstract: This investigation tested if lithium

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Cited by 27 publications

References 20 publications

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Effects of lithium on dopamine D2 receptor expression in the rat brain striatum

Kameda

Miura²,

Suzuki³

et al. 2001

Journal of Neural Transmission

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Effects of lithium on the dopamine D2 receptor expression in the rat brain striatum were studied. Feeding the chow containing 0.2% LiCO3 for 6 days increased the level of the dopamine D2 receptor mRNA, and the transcription rate of the dopamine D2 receptor gene, indicating the stimulatory effects of lithium on the transcription of the dopamine D2 receptor gene. [3H] Spiperone binding to the striatal membranes increased in the rats treated with lithium, while the Western blotting analysis showed no change of the amount of the dopamine D2 receptors. These results suggested that lithium might induce the conformational changes of the dopamine D2 receptors. The methamphetamine-induced locomotor activity was enhanced by the pretreatment with lithium, whereas simultaneous increase in the methamphetamine concentration in the striatum was also observed. These observations suggested that the stimulation of methamphetamine-induced locomotor activity by lithium might be, at least partly, due to either increased sensitivity of the dopamine receptors, or increased concentration of methamphetamine in brain, or combination of both.

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Effects of lithium on dopamine D2 receptor expression in the rat brain striatum

Kameda

Miura²,

Suzuki³

et al. 2001

Journal of Neural Transmission

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Transcriptional mechanisms of lithium action: therapeutic implications

2004

Clinical Neuroscience Research

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Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells

et al. 2001

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Lithium Attenuates Nerve Growth Factor–Induced Activation of AP-1 DNA Binding Activity in PC12 Cells

Abstract: This investigation tested if lithium

Cited by 27 publications

References 20 publications

Effects of lithium on dopamine D2 receptor expression in the rat brain striatum

Effects of lithium on dopamine D2 receptor expression in the rat brain striatum

Transcriptional mechanisms of lithium action: therapeutic implications

Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells

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