Lithium Carbonate Attenuation of Chemotherapy-Induced Neutropenia

Stein, Richard S.; Beaman, Colleen; Ali, Mohamad Akbar; Hansen, Richard M.; Jenkins, David; Jumean, Hani G.

doi:10.1056/nejm197708252970807

Cited by 120 publications

(21 citation statements)

References 7 publications

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“…The use of another trace metal lithium in the form of lithium carbonate has been suggested to be of value in the attenuation of chemotherapy-induced neutropenia (Stein et al, 1978). It is reported to act by mobilising granulocyte precursors; however such effects may also increase long-term marrow depression (Meiser, 1978).…”

Section: Riboflavinmentioning

confidence: 99%

Nutritional Support in Patients with Malignant Disease

Soukop¹,

Calman²

1979

Int J Food Sci Nutr

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Section: Riboflavinmentioning

confidence: 99%

Nutritional Support in Patients with Malignant Disease

Soukop¹,

Calman²

1979

Int J Food Sci Nutr

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“…Administration of lithium carbo nate (U2CO3) has improved neutropenia in cases of Felty's syndrome, aplastic anemia and congenital neutropenia [2][3][4][5][6]. This phenomenon has also been used to attenuate neutropenia in patients receiv ing myelotoxic chemotherapy for cancer [7][8][9][10][11] and for acute leukemia [12][13][14][15], In vitro studies have demonstrated a stimulatory effect of U 2CO3 on granulo poiesis [16] and have also suggested that it acts indirectly by increasing the colony stimulating factor (CSF) production by mononuclear cells [17] or by potentiating the action of CSF [18]. But in a study in which lithium was added to a murine bone marrow liquid culture system, both the number of the granulocyte-committed progenitor cells and of pluripotent stem cells increased substantially, suggesting a more direct effect on the stem cell com partment [19],…”

Section: Introductionmentioning

confidence: 99%

In vitro Effects of Lithium on Granulocyte Colony Formation in Normal Men, in Hematological Disorders and in Small-Cell Carcinoma of the Lung

Devries

Vanluyn

Mulder³

et al. 1983

Acta Haematol

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In a two-layer soft agar system the indirect effect of lithium via colony stimulating factor and/or its direct effect on the granulocyte progenitor cells of bone marrow of healthy volunteers, patients with different hematological disorders, and with small-cell carcinoma of the lung, were evaluated. A significant increase in the number of myeloid colonies was found with a concentration of 0.1 mmol/l lithium carbonate in the feeder layer in all patient groups except those with overt acute myelomonocytic leukemia (AMMoL). No effect was seen if lithium was added to the overlayer. The increment of colonies cultured with lithium in the feeder layer was directly related to the initial number of colonies cultured without lithium (correlation coefficient 0.96). The former colonies had a 1.5- to 2-times larger size than the latter, and cell cycle analysis showed a significant increase in the percentage of cells in S, G2 and M phase. No such effects were seen in AMMoL on the number and size of the colonies and the characteristic growth pattern. In this study lithium has an indirect effect on the number and size of bone marrow myeloid colony formation in healthy people as well as patients with different he-matologic cell disorders and small-cell carcinoma of the lung, while no such influence was observed with overt AMMoL patients.

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“…During lithium treatment of affective illness granulocytosis is often observed, and lithium administration has been found ther apeutically effective in certain granulocyto penic states, e.g. Felty's syndrome [1] and granulocytopenia due to cancer chemo therapy [4,5J. Orr and McKernan [3], on the other hand, recently reported relapse of myeloid leukaemia after 7 weeks of lithium treatment.…”

Section: Introductionmentioning

confidence: 99%

Development of Acute Myeloid Leukaemia during Lithium Treatment

Nielsen¹

1980

Acta Haematol

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Development of acute myeloid leukaemia in 2 patients given long-term lithium treatment for affective illness is reported. The 1st was a 49-year-old man who was found to have acute myelomonocytic leukaemia after about 1 year of lithium treatment. He died 2 days after admission from haemorrhagic pericarditis. The 2nd patients was a 32-year-old woman given lithium for about 12 years. Thereafter she developed acute myeloid leukaemia within a few months. A remission induction regime with daunorubicin and cytosine arabinoside was successful and she is now in a full remission state.

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Lithium Carbonate Attenuation of Chemotherapy-Induced Neutropenia

Cited by 120 publications

References 7 publications

Nutritional Support in Patients with Malignant Disease

Nutritional Support in Patients with Malignant Disease

In vitro Effects of Lithium on Granulocyte Colony Formation in Normal Men, in Hematological Disorders and in Small-Cell Carcinoma of the Lung

Development of Acute Myeloid Leukaemia during Lithium Treatment

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