Lithium chloride changes sensitivity of hamster rhythm to light pulses

Effects of lithium salts on the behaviour and the orcadian system ofMesocricetus auratusW.

“…If true, the phase response curve towards light should be changed by Li + . Work on this line has been reported elsewhere (Han, 1984).…”

“…A period shortening of Li + was found in the tropical bat Taphozous (Subbaraj, 1981). A different strain of hamsters shows clear period lengthening by Li + (Han, 1984;Reinhard, 1983).…”

Effect of lithium chloride on the lower range of entrainment in Syrian hamsters

“…Under the influence of lithium the advance phase shifts were reduced, whereas the delaying part was slightly increased (Han, 1984). Reducing the intensity of the light pulse to 7.5 lux leads to a phase response curve under water identical to the one with 75 lux under lithium (Han, pers.…”

“…Since synchronization to LD cycles is supposed to depend on the phase response curve , the results could be explained by a change of the phase response curve to light pulses under the influence of lithium salts. This was checked experimentally by Han (1984).…”

“…Han (1984) investigated the sensitivity of hamsters to light pulses. She found an asymmetrical weak phase response curve with small delays and larger advances.…”