Lithium chloride enhances bone regeneration and implant osseointegration in osteoporotic conditions

Jin, Yifan; Xu, Lihua; Hu, Xiaohui; Liao, Shixian; Pathak, Janak L.; Liu, Jinsong

doi:10.1007/s00774-016-0783-6

Cited by 36 publications

(24 citation statements)

References 42 publications

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“…An in vitro study illustrated that LiCl motivated Wnt signalling by inhibiting the activity of GSK3β and by counteracting inhibition of the Wnt pathway mediated by DKK1 (an inhibitor of Wnt) . LiCl may continue to enhance bone formation and reduce bone resorption, even in osteoporotic conditions, as shown in rats . Consistent with previous studies, our results showed that lithium‐enhanced alveolar bone formation during the orthodontic retention stage; therefore, LiCl may prevent relapse after active OTM.…”

Section: Discussionsupporting

confidence: 89%

Lithium enhances alveolar bone formation during orthodontic retention in rats

Pan

Yin

et al. 2017

Orthod Craniofacial Res

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Section: Discussionsupporting

confidence: 89%

Lithium enhances alveolar bone formation during orthodontic retention in rats

Pan

Yin

et al. 2017

Orthod Craniofacial Res

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“…In another study, distracted osteotomies in rats achieved complete bony restoration after 10 weeks of daily 200 mg/kg lithium . In a recently published paper, Jin et al reported an anabolic impact of lithium in osseointegration of tibial implants in OVX rats. Stereologic properties of bone adjacent to the implant and the implant push‐out strength significantly improved with 150 mg/kg given every 2 days for 3 months compared to a control treated OVX group.…”

Section: Discussionmentioning

confidence: 94%

“…To minimize the risk of lithium toxicity, serum levels must be maintained below its safe limit. The daily administration of 20 mg/kg of lithium used in this study translates to a dose representing 25–30% of the minimum prescribed maintenance dose used in psychiatric treatment . Combined with the short 2 week duration of use, the risk of lithium side effects in the context of fracture healing is small.…”

Section: Discussionmentioning

confidence: 99%

Low‐dose lithium regimen enhances endochondral fracture healing in osteoporotic rodent bone

Vachhani

Whyne

Wang

et al. 2017

Journal Orthopaedic Research

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Osteoporotic bone fractures are highly prevalent and involve lengthy recovery. Lithium, commonly used in psychiatric medicine, inhibits glycogen synthase kinase-3β in the Wnt/β-catenin pathway, leading to up-regulation of osteogenesis. Our recent preclinical work demonstrated that a 20 mg/kg lithium dose administered beginning 7 days post-fracture for 14 days optimally improved femoral fracture healing in healthy rats at 4 weeks post fracture (46% higher torsional strength). In this study, lithium treatment was evaluated for healing of osteoporotic bone fractures. Six-month-old ovariectomized rats were subjected to closed, load-drop induced femoral diaphyseal fracture. Two regimens involving treatment initiation on day 7 and day 10, respectively, 20 mg/kg/day oral dose and 14 days duration were evaluated. Femurs of lithium- vs. saline- treated rats were analyzed at 4 weeks (for day 7 onset regimen) or 6 weeks (for day 10 onset regimen) post-fracture by stereology and torsional mechanical testing. Initiation on day 10 led to a significant 50% higher maximum yield torque (primary outcome measure) at 6 weeks (309 vs. 206 N-mm, p = 0.005; n = 7, 7). Initiation on day 7 suggested a trend toward a more modest improvement in maximum yield torque (13%) evaluated at 4 weeks post-fracture (234 vs. 206 N-mm, p = 0.10; n = 10, 13). Qualitatively, lithium-treated femurs demonstrated better periosteal and mineralized callus bridging in the day 10 initiation group. Lithium is a widely-available, orally administered, low-cost drug, which represents a feasible pharmacological intervention for both healthy and osteoporotic fracture healing. This study provides important guidelines for future clinical evaluation of lithium in osteoporotic fracture patients. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1783-1789, 2018.

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“…We have found that LiCl inhibits lipogenesis by regulating Wnt and Hh signaling, thereby significantly promotion of osteogenesis of human BMSCs [13]. Moreover, LiCl enhanced bone mass and implant oseoientegration in rats with osteoporosis [14].…”

Section: Introductionmentioning

confidence: 84%

“…In recent years, the roles of LiCl on bone homeostasis in vivo have also been studied. LiCl promotes implant osseointegration and osteogenesis in osteoporotic rats [28,29]. LiCl treatment increased the alveolar bone mass during orthodontic retention [30].…”

Section: Discussionmentioning

confidence: 99%

Lithium chloride enhances osteoblast differentiation and resists senile osteoporosis

Bao

Tang

et al. 2020

Preprint

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Background Lithium chloride (LiCl) is commonly used in the clinic for the treatment of bipolar and other mental disorders. LiCl is an inhibitor of GSK-3β, and has been reported to modulate the balance of adipogenesis and osteogenesis. But, whether LiCl impacts bone formation and homeostasis in senile osteoporosis is still unclear. Methods Analysis of tibia in 2, 5, 7 and 10 months old C57BL/6 male mice were performed by MicroCT (μCT). 7 months old wild-type mice were treated with LiCl orally 0, 100 or 200 mg/kg for 3 months and then tested by μCT. The levels of osteogenesis marker genes and Wnt signaling target genes in bone marrow stromal cells (BMSCs) were detected by reverse transcription quantitative polymerase chain reaction and immunostaining. BMSCs were induced osteoblast differentiation and tested by Alizarin red S staining. Results μCT analyses of C57BL/6 mice showed that bone mineral density (BMD) and trabecular thickness (Tb.Th) increased until the bone mass peaked (5 months) and then began to fall subsequently. LiCl dramatically enhanced bone mass in the senile osteoporotic conditions, represented by increased ratio of bone volume to tissue volume (BV/TV), and decreased in trabeculae separation (Tb.Sp). Moreover, LiCl significantly increased both canonical osteoblastogenesis and Wnt signaling activity without affecting hormones. Conclusion This study uncovered the role of LiCl in canonical Wnt signaling and bone formation and have provided the evidence that LiCl may potentially repress senile osteoporosis.

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Lithium chloride enhances bone regeneration and implant osseointegration in osteoporotic conditions

Cited by 36 publications

References 42 publications

Lithium enhances alveolar bone formation during orthodontic retention in rats

Lithium enhances alveolar bone formation during orthodontic retention in rats

Low‐dose lithium regimen enhances endochondral fracture healing in osteoporotic rodent bone

Lithium chloride enhances osteoblast differentiation and resists senile osteoporosis

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