Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer

Wu, Hao; Zhang, Yin; Liang, Jiawei; Wu, Jianzhuang; Zhang, Yixuan; Su, Haochen; Zhang, Qiyue; Shen, Yonghua; Shen, Shanshan; Wang, Lei; Zou, Xiaoping; Hang, Cheng; Zhang, Shu; Lv, Ying

doi:10.1016/j.tranon.2023.101792

Translational Oncology

2023

DOI: 10.1016/j.tranon.2023.101792

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Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer

Hao Wu,

Yin Zhang,

Jiawei Liang

et al.

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2024

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Cited by 2 publications

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Solid–liquid Phase Equilibria of Li⁺, Na⁺, Ca²⁺//Cl^––H₂O Quaternary System at 298.15 and 323.15 K

Li,

Zhou,

Yang

et al. 2024

J. Chem. Eng. Data

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The solid−liquid phase equilibria of the Li + , Na + , Ca 2+ //Cl − −H 2 O quaternary system at 298.15 and 323.15 K are studied via the isothermal solubility phase equilibrium method. The solubility data and liquid properties of density and pH are obtained. The phase diagrams of the quaternary systems, including the water free diagram, the water diagram, and the dry salt diagram, are plotted to show the phase regions, water content, and salting-in effect. NaCl occupies the largest phase region at both 298.15 and 323.15 K. One double salt LiCl•CaCl 2 •5H 2 O occurs at 298.15 K and builds up two invariant points; one incommensurate invariant point saturated by (NaCl, LiCl•H 2 O, LiCl•CaCl 2 •5H 2 O) and one commensurate invariant point saturated by (NaCl, CaCl 2), but at 323.15 K, no double salt forms. The salting-in effect that happened in ternary systems still occurs in the quaternary Li + , Na + , Ca 2+ // Cl − −H 2 O system at both temperatures. NaCl saturated concentration increases with LiCl and CaCl 2 contents and results in a very high total salt content at commensurate invariant points, e.g., they are 56.92 and 60.62% at 298.15 and 323.15 K, respectively.

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Solid–liquid Phase Equilibria of Li⁺, Na⁺, Ca²⁺//Cl^––H₂O Quaternary System at 298.15 and 323.15 K

Li,

Zhou,

Yang

et al. 2024

J. Chem. Eng. Data

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Polyunsaturated Fatty Acids from Thamnidium elegans and Mortierella alpina Suppress Prostate Cancer Cell Proliferation and Migration

Kalampounias,

Dritsas,

Karayannis

et al. 2024

Fermentation

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Thamnidium elegans and Mortierella alpina are two oleaginous fungi that belong to Mucoromycota that synthesize polyunsaturated fatty acids, which are credited with multiple health benefits and possible anticancer properties. These fungi were cultivated on culture media, with glucose or glycerol as a carbon source. After extracting the lipids, we transformed them into fatty acid lithium salts (FALSs), which are water-soluble and absorbable mammalian cells, including DU-145 and PC-3 cancer cells. The two cell lines, both long-established prostate cancer models, were treated with FALSs and indicated increased susceptibility to the lipid derivatives. The viability and proliferation rates were significantly reduced, as well as their migratory capabilities, which were significantly impaired compared to olive oil-derived FALS, which was used as a control substance. We conclude that the FALS derivatives of microbial lipids from these organisms exhibit anticancer effects, by suppressing the proliferation and migration of human prostate cancer cell lines.

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Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer

Cited by 2 publications

References 47 publications

Solid–liquid Phase Equilibria of Li⁺, Na⁺, Ca²⁺//Cl^––H₂O Quaternary System at 298.15 and 323.15 K

Solid–liquid Phase Equilibria of Li⁺, Na⁺, Ca²⁺//Cl^––H₂O Quaternary System at 298.15 and 323.15 K

Polyunsaturated Fatty Acids from Thamnidium elegans and Mortierella alpina Suppress Prostate Cancer Cell Proliferation and Migration

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Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer

Cited by 2 publications

References 47 publications

Solid–liquid Phase Equilibria of Li+, Na+, Ca2+//Cl––H2O Quaternary System at 298.15 and 323.15 K

Solid–liquid Phase Equilibria of Li+, Na+, Ca2+//Cl––H2O Quaternary System at 298.15 and 323.15 K

Polyunsaturated Fatty Acids from Thamnidium elegans and Mortierella alpina Suppress Prostate Cancer Cell Proliferation and Migration

Contact Info

Product

Resources

About

Solid–liquid Phase Equilibria of Li⁺, Na⁺, Ca²⁺//Cl^––H₂O Quaternary System at 298.15 and 323.15 K

Solid–liquid Phase Equilibria of Li⁺, Na⁺, Ca²⁺//Cl^––H₂O Quaternary System at 298.15 and 323.15 K