Lithium engages autophagy for neuroprotection and neuroplasticity: Translational evidence for therapy

Puglisi‐Allegra, Stefano; Lazzeri, Gloria; Busceti, Carla Letizia; Giorgi, Filippo Sean; Biagioni, Francesca; Fornai, Francesco

doi:10.1016/j.neubiorev.2023.105148

Cited by 5 publications

(4 citation statements)

References 235 publications

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“…In PD, the LC is one of the first areas to undergo degeneration. The NE system also exerts anti-inflammatory and neuroprotective effects on DA neurons in the VTA, protecting them from degeneration; consequently, it is highly probable that NE damage in the LC will affect the disease progression (see [82] for a review).…”

Section: General Discussion Limitations and Conclusionmentioning

confidence: 99%

“…Remarkably, the LC neurodegeneration that characterizes PD and the loss of NE projections are likely to affect pain sensitivity through different mechanisms involving different brain networks, and through the modulation of DA transmission in the NAc. In fact, the LC-VTA connection modulates DA transmission [82,83].…”

Section: General Discussion Limitations and Conclusionmentioning

confidence: 99%

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Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players

Latagliata,

Orsini,

Cabib

et al. 2023

Biomedicines

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Deficits in cognitive flexibility have been characterized in affective, anxiety, and neurodegenerative disorders. This paper reviews data, mainly from studies on animal models, that support the existence of a cortical–striatal brain circuit modulated by dopamine (DA), playing a major role in cognitive/behavioral flexibility. Moreover, we reviewed clinical findings supporting misfunctioning of this circuit in Parkinson’s disease that could be responsible for some important non-motoric symptoms. The reviewed findings point to a role of catecholaminergic transmission in the medial prefrontal cortex (mpFC) in modulating DA’s availability in the nucleus accumbens (NAc), as well as a role of NAc DA in modulating the motivational value of natural and conditioned stimuli. The review section is accompanied by a preliminary experiment aimed at testing weather the extinction of a simple Pavlovian association fosters increased DA transmission in the mpFC and inhibition of DA transmission in the NAc.

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Section: General Discussion Limitations and Conclusionmentioning

confidence: 99%

Section: General Discussion Limitations and Conclusionmentioning

confidence: 99%

Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players

Latagliata,

Orsini,

Cabib

et al. 2023

Biomedicines

Self Cite

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“…Lithium can reduce excitatory glutamate neurotransmission and increase inhibitory (gamma-aminobutyric acid, GABA) neurotransmission, overall reducing or "dampening down" excitatory neurotransmission in the brain. 13 Further, lithium has been identified as a potential therapeutic strategy from treatment of neuropsychiatric conditions due to its ability to modulate autophagy. 14 It was hypothesized that lithium may hold utility in Bailey's case through these aforementioned mechanisms.…”

Section: The Neurobiological Inpatient Interventionmentioning

confidence: 99%

Bridging the Divide: An Integrated Neurobio-Psycho-Social Approach to Treating Antibody Negative Inflammatory Encephalitis in a School-Aged Child

Hawkes,

Dale,

Scher

et al. 2024

Harv Rev Psychiatry

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“…Maintenance of adequate levels of autophagy are also essential for brain physiopathology ( Jimenez-Sanchez et al, 2022 ). Numerous studies have shown that alteration in autophagy level is regarded as a promising therapeutic strategy for treating various nervous system disease, such as neuroprotection after injury ( Sheng et al, 2010 ; Wang et al, 2012 ; Puglisi-Allegra et al, 2023 ), stroke rehabilitation ( Han et al, 2021 ), and ischemic stroke ( Wang et al, 2018 ; Zhu et al, 2022 ). Although autophagy plays a key role in brain pathophysiology, its role may vary with different nervous system disease.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric analysis and visualized study of research on autophagy in ischemic stroke

Chen,

et al. 2023

Front. Pharmacol.

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Aims: To summarize and clarify the current research status and indicate possible future directions in the field of autophagy in ischemic stroke, we performed a comprehensive and multidimensional bibliometric analysis of the literature in this field published from 2011 to 2022.Methods: We retrieved articles on the field of autophagy in ischemic stroke published between 2011 and 2022 from Web of Science Core Collection (WOSCC). VOSviewer (version 1.6.19) and CiteSpace (version 6.2.R2 Basic) were used to identify the leading topics as well as generate visual maps of Countries/regions, organizations, authors, journals, and keyword networks in the related field.Results: A total of 568 publications were contained in this research. The journal with the most publications were Front Pharmacol, Mol Neurobiol, and Neuroscience. China was the most productive country with respect to co-authorship, with the Capital Med Univ being the organization with the most. co-authorships. In terms of authorship analysis, eight of the top 10 most contributive authors were from China. The co-occurring author keywords can be divided into three main clusters, including “protective effect of autophagy in ischemic stroke,” “autophagy-targeted therapy for ischemic stroke,” and “mitochondrial function in cerebral ischemia-reperfusion injury”.Conclusion: This bibliometric analysis helps us reveal the current research hotspots in the research field of autophagy in ischemic stroke and guide future research directions. Subsequent trends in this special field are likely to identify and develop novel autophagy-targeted therapy strategies to effectively prevent and treat ischemic stroke.

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Lithium engages autophagy for neuroprotection and neuroplasticity: Translational evidence for therapy

Cited by 5 publications

References 235 publications

Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players

Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players

Bridging the Divide: An Integrated Neurobio-Psycho-Social Approach to Treating Antibody Negative Inflammatory Encephalitis in a School-Aged Child

Bibliometric analysis and visualized study of research on autophagy in ischemic stroke

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