Lithium in Haematology: A Case of Acute Intoxication

Efira, André; Laethem, Y. Van; Ectors, Michel Paul; Unger, Jeff

doi:10.1159/000207314

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Mild electrolyte disorders, mild renal failure, and the patient's age could have contributed to the development of intoxication. This case report shows that sometimes even short-term lithium administration may be lifethreatening and should thus be prescribed cautiously [103].…”

Section: Aplastic Anemiamentioning

confidence: 82%

Lithium and hematology: established and proposed uses

Focosi

Azzarà

Kast

et al. 2008

Journal of Leukocyte Biology

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Lithium (as lithium carbonate) is an inexpensive drug, widely used in psychiatry for over 50 years in treatment of mood instability (bipolar disorder) and as an adjunct to antidepressants. Hematological effects of neutrophilia and increased circulating CD34+ cells of marrow origin have long been known. Lithium was at the center of hematological investigations in the 1980s, but no definitive use in hematology has yet emerged. We review evidence that lithium increases G-CSF and augments G-CSF effects. We suggest possible therapeutic uses of lithium in neutropenia. In bone marrow transplantation, preharvest lithium-assisted hematopoietic stem cell mobilization may be useful as well.

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Section: Aplastic Anemiamentioning

confidence: 82%

Lithium and hematology: established and proposed uses

Focosi

Azzarà

Kast

et al. 2008

Journal of Leukocyte Biology

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Combined action of lead and lithium on essential and nonessential elements in rat blood

Singh

Dhawan

Mangal

et al. 1994

Biol Trace Elem Res

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The effects of lead and lithium ingestion, separately and in combination, on the levels of K, Fe, Cu, Zn, Br, Rb, and As in rat blood were studied by the Energy Dispersive X-ray Fluorescence technique. Two different doses of lead acetate, i.e., 50 and 100 mg/Kg body wt (low and high doses), were administered orally to rats, daily, for 1 and 4 months (short and long terms), whereas lithium in the form of lithium carbonate was given to rats in food (1.1 g/kg diet) for 1 and 4 mo separately, and also to rats receiving lower and higher doses of lead. K levels were found to be depressed significantly with lead treatment, whereas Fe contents were enhanced marginally after 1 mo of treatment when only the higher dose of lead was given. As, Br, and Rb contents were found to be elevated following lead treatment for short and long terms at both the dose levels. However, Cu contents were lowered, whereas Zn contents were raised only after long term treatment with lead. The Fe, Cu, As, and Br contents remained unaltered, whereas K, Rb, and Zn contents were reduced significantly when lithium was administered for short term. Moreover, Cu and Fe levels were also found to be reduced and Br contents were enhanced only after long term treatment. During the combined treatment with lead and lithium for short and long terms, the levels of K, As, and Rb were observed to decrease, whereas Fe contents were enhanced when estimated for both doses of lead. On the contrary, Cu levels were lowered only with the higher dose of lead acetate when given in combination with lithium for 1 and 4 mo. Br contents were only effectively decreased after 4 mo of treatment.

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Lithium in Haematology: A Case of Acute Intoxication

Cited by 2 publications

References 6 publications

Lithium and hematology: established and proposed uses

Lithium and hematology: established and proposed uses

Combined action of lead and lithium on essential and nonessential elements in rat blood

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