Lithium Intoxication as a cause of reversible dementia mimicking FDG PET features of Alzheimer’s disease

Abstract

ABSTRACT. Rapidly progressive dementia (RPD) is a rare neurological disorder. Drug toxicity is among the differential diagnoses, including the use of lithium, in which an overdosage might cause cognitive dysfunction. Clinical suspicion, laboratory confirmation, and drug interruption are key points in the management of lithium intoxication. We described a 66-year-old female patient under treatment with lithium who developed an RPD associated with parkinsonian symptoms. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) showed an “Alzheimer-like” pattern, while cerebrospinal fluid biomarkers for the disease were negative. There was a significant clinical and radiological improvement after lithium interruption. Lithium intoxication is a potentially reversible cause of RPD, as demonstrated in this case report. Drug discontinuation should be considered even in patients with normal levels of this metal, if cognitive impairment is detected. 18F-FDG PET/CT images may show an “Alzheimer-like” image pattern in acute intoxication and are useful for monitoring these patients.

Pseudodementia in Patients with Unipolar and Bipolar Disorders: A Case Series and Literature Review

“…Three additional records were identified through other sources (citations in reference lists of screened papers and reviews) and assessed for eligibility [ 30 , 31 , 32 ]. Two articles focusing on reversible dementia, respectively, due to lithium intoxication and vitamin B12 and folate deficiency, were excluded [ 33 , 34 ]. A total of 15 studies were finally included in the systematic review.…”

Lithium bidirectionally regulates depression- and mania-related brain functional alterations without worsening cognitive function in patients with bipolar disorder

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