Lithium ion selective electrodes based on crown ethers for serum lithium assay

Kimura, Kazuhiro; Oishi, Hideki.; Miura, Tsutomu; Shono, Toshiyuki

doi:10.1021/ac00146a004

Cited by 82 publications

(42 citation statements)

References 16 publications

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“…Even if the M+-ion is so hydrophilic that its transfer can occur only at a very large potential beyond the polarizable potential range, the presence of a proper ionophore enables one to observe a current due to the facilitated M+-ion transfer across the 0/W interface, which serves as an amperometric M+-ISE surface. Recently, Kudo et alll studied the transfers of Li+ and Na+ at the nitrobenzene/water interface facilitated by dibenzyl-l4-crown- 4 and bis(8-quinolyloxy)propane derivatives to evaluate the potentiometric selectivity coefficients.…”

mentioning

confidence: 99%

Voltammetric Lithium Ion-Selective Electrodes Based on Ion Transfer at the Oil/Water Interface Facilitated by Neutral Ionophores

1994

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Voltammetric measurements were performed for the transfers of Li+ and Na+ at an oil/water interface facilitated by neutral ionophores including 14-crown-4 derivatives. For the organic solvent, nitrobenzene, o-nitrophenyloctylether (NPOE) and o-nitrophenylphenylether (NPPE) were examined. The interface between water and NPPE containing 20 mM dibenzyl-l4-crown-4 was found to serve best for the ion-selective-electrode (ISE) surface for the voltammetric determination of Lit A test of this voltammetric Li+-ISE using artificial serum showed that the interference from a large amount (ca. 140 mM) of Na+ in blood can be easily avoided by detecting the Na+ concentration simultaneously with the same electrode.

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confidence: 99%

Voltammetric Lithium Ion-Selective Electrodes Based on Ion Transfer at the Oil/Water Interface Facilitated by Neutral Ionophores

1994

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“…A bulky dibenzo-14-crown-4 ether exhibited a preference for lithium of 800:1 in an ISE, and was used to measure lithium in undiluted serum by placing a dialysis membrane over the electrode (21). A di-n-butylamide 14-crown-4 ionophore exhibited a selectivity of 800:1 and could be used to measure lithium in serum diluted 1:10 with a buffer (22).…”

Section: Ion-selective Electrodesmentioning

confidence: 99%

Reagents for Lithium Electrodes and Sensors for Blood Serum Analysis

Christian

2002

Sensors

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Abstract:The measurement of lithium in blood serum requires high selectivity since the blood contains about 140 mM sodium compared to the 0.5-1.5 mM lithium level in manic depressive patients under treatment with lithium salts. This review traces the development of optical and potentiometric methods for the selective measurement of lithium in the presence of sodium. Selectivities of over 1,000:1 are achievable with properly designed ionophores.

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“…Up to now, commercially available 6,6-dibenzyl-1,4,8-11-tetraoxosiclotetradecane has been usually preferred as an ionophore in the construction of Li + -selective electrodes with inner reference solution [26]. The present study describes an alternative microsized PVC membrane Li + -selective electrode without inner reference solution by using the ionophore mentioned above.…”

Section: Introductionmentioning

confidence: 99%

“…When the literature is looked over, various types of Li + -selective electrodes based on organic and inorganic membranes are encountered [17][18][19][25][26][27][28][29][30][31][32][33][34][35][36][37]. Most of them contain internal reference solutions and have been prepared by using PVC membrane technology.…”

Section: Introductionmentioning

confidence: 99%