Lithium Lithium in aggressive behavior

Schiff, Harold B.; Sabin, Thomas D.; Geller, Alan C.; Alexander, Leo; Mark, Vernon H.

doi:10.1097/00004714-198304000-00025

Cited by 7 publications

(9 citation statements)

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“…In addition to their use to treat affective disorders, lithium and valporate have been used for the management of aggressive behaviors in various pathological conditions, including mental retardation, brain injury, autism, schizophrenia, attention-deficit/hyperactivity disorder, conduct disorder, and pervasive developmental disorder (Bellus et al, 1996;Glenn et al, 1989;Goetzl et al, 1977;Malone et al, 1994;McDougle et al, 2003;Platt et al, 1981;Schiff et al, 1982;Shader et al, 1974;Sheard, 1975Sheard, , 1984Silva et al, 1993;Swann, 2003;Weller et al, 1999;Wroblewski et al, 1997). Lithium has also been reported to block aggressiveness in laboratory animals (Sheard, 1975).…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine Causes Alterations in the MAP Kinase-Related Pathways in the Brains of Mice that Display Increased Aggressiveness

Sokolov

Cadet

2005

Neuropsychopharmacol

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Aggressive behaviors have been reported in patients who suffer from some psychiatric disorders, and are common in methamphetamine (METH) abusers. Herein, we report that multiple (but not single) injections of METH significantly increased aggressiveness in male CD-1 mice. This increase in aggressiveness was not secondary to METH-induced hyperactivity. Analysis of protein expression using antibody microarrays and Western blotting revealed differential changes in MAP kinase-related pathways after multiple and single METH injections. There were statistically significant (po0.05) decreases in MEK1, Erk2p, GSK3a, 14-3-3e, and MEK7 in the striata of mice after multiple injections of METH. MEK1 was significantly decreased also after a single injection of METH, but to a much lesser degree than after multiple injections of METH. In the frontal cortex, there was a statistically significant decrease in GSK3a after multiple (but not single) injections of METH. These findings suggest that alterations in MAP kinase-related pathways in the prefronto-striatal circuitries might be involved in the manifestation of aggressive behaviors in mice. Neuropsychopharmacology (2006) 31, 956-966.

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Section: Discussionmentioning

confidence: 99%

Methamphetamine Causes Alterations in the MAP Kinase-Related Pathways in the Brains of Mice that Display Increased Aggressiveness

Sokolov

Cadet

2005

Neuropsychopharmacol

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“…Lithium, for example, reduced impulsive aggressive behavior as measured by a reduction in infractions while on the medication in one study [72], yet in another appeared to do the opposite [73]. Carbamazepine and valproate have reduced impulsivity in post-traumatic stress disorder patients or behavioral dyscontrol syndrome [74], and divalproex sodium has been helpful, as well [75], as cited by Hollander et al [61].…”

Section: Conceptualizing Suicidal Behavior and Other Forms Of Self-harmmentioning

confidence: 99%

Suicidal and self-injurious behavior in personality disorder: Controversies and treatment directions

Stanley

2002

Curr Psychiatry Rep

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Contrary to common clinical perceptions, individuals with personality disorders attempt and commit suicide at nearly the same rate as individuals with major depression. In particular, those with borderline personality disorder are at high risk for suicidal behavior and nonsuicidal self-injury. Yet there is significant controversy surrounding the diagnosis of borderline personality disorder in terms of its existence, its definition and symptom structure, its Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) axis location, and its importance as a contributing factor to suicidality and nonsuicidal self-injury. Furthermore, both suicidal and nonsuicidal self-harm is prominent in borderline personality disorder. There is often confusion between suicidal and nonsuicidal self-injury with one sometimes mistaken for the other. Nonsuicidal self-injury is sometimes met with hospitalization, because it is viewed as life threatening. Alternately, the potential lethality of suicidal behavior is underestimated, because it occurs in the context of multiple low lethality self-harm behaviors. It is possible to view these behaviors as distinct yet on a spectrum in borderline personality-disordered patients. With respect to treatment of self-injury in personality disorders, some recent pharmacotherapy trials have been conducted, though efficacy is often unclear. Findings with respect to psychotherapy, particularly dialectical behavior therapy, a form of cognitive behavioral treatment, are promising.

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“…All the studies used CBZ. Aggressive behavior improved in all subjects of all studies except for two (Monroe, 1986;Schiff et al, 1982).…”

Section: Resultsmentioning

confidence: 78%

“…In both studies, the treating psychiatrists were not masked to the treatment condition but in the study by Mattes (1990), an additional masked (to medication status) rater was included. Three were single case reports (Schiff et al, 1982;Stone et al, 1986;Yassa and Dupont, 1983). Three case series were also identified (Hakola and Laulumaa, 1982;Monroe, 1986;Reeves et al, 2003).…”

Section: Resultsmentioning

confidence: 96%

Predictive Value of Isolated Epileptiform Discharges for a Favorable Therapeutic Response to Antiepileptic Drugs in Nonepileptic Psychiatric Patients

Boutros

Kirollos

Pogarell

et al. 2014

Journal of Clinical Neurophysiology

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The efficacy of antiepileptic drugs (AEDs) in treating behavioral symptoms in nonepileptic psychiatric patients with abnormal EEGs is currently unknown. Although isolated epileptiform discharges have been reported in many psychiatric conditions, they are most commonly observed in patients with aggression, panic, or autistic spectrum disorders. The literature search was guided by 3 criteria: (1) studies had patients who did not experience seizures, (2) patients had EEGs, and (3) an AED was administered. Most important finding is that the number of "controlled" studies was extremely small. Overall, most reports suggest that the use of an AED can be associated with clinical and, at times, improved EEG abnormalities. Additionally, six controlled studies were found for other psychiatric disorders, such as learning disabilities with similar results. Overall, the use of anticonvulsants to treat nonepileptic psychiatric patients needs further controlled studies to better define indications, adequate EEG work-up, best AED to be used, and optimal durations of treatment attempts.

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Lithium Lithium in aggressive behavior

Cited by 7 publications

References 0 publications

Methamphetamine Causes Alterations in the MAP Kinase-Related Pathways in the Brains of Mice that Display Increased Aggressiveness

Methamphetamine Causes Alterations in the MAP Kinase-Related Pathways in the Brains of Mice that Display Increased Aggressiveness

Suicidal and self-injurious behavior in personality disorder: Controversies and treatment directions

Predictive Value of Isolated Epileptiform Discharges for a Favorable Therapeutic Response to Antiepileptic Drugs in Nonepileptic Psychiatric Patients

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