Lithium perchlorate-induced electrophilic activation: one-pot synthesis of 3-aryl-2-thioxotetrahydropyrimidin-4-one derivatives from aryl isothiocyanates

Total Synthesis of a Pyrroloindoloquinazoline Alkaloid

“…The chemoselective reduction of the imine bond in tryptanthrin using this reagent had been reported . It was then cyclized by an electrophilic activation mechanism using lithium perchlorate and triethylamine in acetonitrile to obtain the target molecule. However, in order to further simplify the process and improve the yield we envisaged a different approach.…”