Lithium promotes malignant transformation of nontumorigenic cells in vitro

Sudo, Makoto; Hashimoto, Kazunori; Yoshinaga, Masafumi; Azimi, Mohammad Daud; Fayaz, Said Hafizullah; Hamajima, Nobuyuki; Kondo-Ida, Lisa; Yanagisawa, Kiyoshi; Kato, Masashi

doi:10.1016/j.scitotenv.2020.140830

Cited by 10 publications

(4 citation statements)

References 44 publications

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“…It is noteworthy that some of the side effects in patients treated with lithium are related to RIOM and taste disorder, including xerostomia and metallic taste (Chacko et al 1987;Gelenberg et al 1989). In addition, the role of lithium in tumorigenesis and cancer progression remains controversial depending on tumor types and the research model (Zhu et al 2011;Sudo et al 2020). Therefore, further studies are warranted to optimize the dose and way of delivery to maximize the benefits and lessen the adverse effects of LiCl in the treatment of RIOM and taste dysfunction.…”

Section: Discussionmentioning

confidence: 99%

LiCl Promotes Recovery of Radiation-Induced Oral Mucositis and Dysgeusia

Zhu

Zhang

et al. 2021

J Dent Res

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Oral mucositis and taste dysfunction are frequently complained by patients with head and neck cancer receiving radiotherapy, challenging the clinical outcome of cancer treatment. Recent studies have indicated the protective role of Wnt/β-catenin signaling in radiation-induced oral mucositis (RIOM) and its pivotal role in the development and self-renewal of taste buds. The current study hypothesizes that lithium chloride (LiCl), a potent activator of the Wnt/β-catenin signaling pathway, can promote the postirradiation restoration of oral mucosa integrity and taste function. To validate this hypothesis, we established a RIOM mouse model and evaluated the treatment efficacy of LiCl on oral mucositis and taste dysfunction in comparison with keratinocyte growth factor (KGF), an agent approved by the US Food and Drug Administration for oral mucositis. The results showed that LiCl alleviated the weight loss and tongue ulceration of RIOM mice, promoted proliferation of basal epithelial cells, and inhibited epithelial-mesenchymal transition in tongue mucosa. More important, elevated taste bud renewal and dysgeusia recovery toward sweetness were observed in RIOM mice treated with LiCl as compared to those treated by KGF. Collectively, our data demonstrate that LiCl can mitigate oral mucositis and rescue taste alteration induced by irradiation, and activation of Wnt/β-catenin signaling may represent a promising therapy to improve the quality of life of patients receiving radiotherapy.

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Section: Discussionmentioning

confidence: 99%

LiCl Promotes Recovery of Radiation-Induced Oral Mucositis and Dysgeusia

Zhu

Zhang

et al. 2021

J Dent Res

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“…The main study protocol was reviewed and approved (2008-0618 and 2013-0070) by the Ethics Committee, as reported previously. 32 , 33 All participants provided written informed consent after understanding the protocol.…”

Section: Methodsmentioning

confidence: 99%

Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice

Kagawa,

Ohgami,

et al. 2023

European Heart Journal Open

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Aims There has been a shortage of human studies to elucidate the association between serum arsenic levels and the prevalence of hypertension. This study multidirectionally investigated associations among arsenic exposure, dietary ingestion, and the risk of hypertension by combined human epidemiological and mouse experimental studies. Methods and results This study focused on the total arsenic level in fasting serum, a biomarker of arsenic exposure. Associations among ingestion frequencies of 54 diet items of Japanese food separated into six categories, total arsenic level in fasting serum, and the prevalence of hypertension were investigated in 2709 general people in Japan. Logistic regression analysis demonstrated a dose-dependent association between serum arsenic level and hypertension and a positive association between the ingestion of fish meat and hypertension. Further analysis showed that the latter association was fully mediated by increased fasting serum arsenic levels in humans. Similarly, oral exposure to the putative human-equivalent dose of arsenic species mixture with the same ratios in a common fish meat in Japan increased systolic blood pressure and arsenic levels in fasting serum in mice. Conclusion This interdisciplinary approach suggests that fish-meat ingestion is a potential risk factor for arsenic-mediated hypertension. Because the increased consumption of fish meat is a recent global trend, health risks of the increased ingestion of arsenic via fish meat should be further investigated.

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“…Since metal elements can modulate immune and in ammatory reactions [6], health disturbances caused by exposure to air pollutants containing heavy metal elements are widely recognized [7][8][9][10]. Researchs have shown that pollen collected from heavily air-polluted areas or near roads with heavy tra c exhibits stronger immunostimulatory activity compared to pollen collected from unpolluted areas or rural meadows [11].…”

Section: Introductionmentioning

confidence: 99%

Association Between Allergic Rhinitis and Serum Lead in American Adults

Wang,

Zhou,

Huang

et al. 2024

Preprint

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Background: Studies have shown a link between allergic rhinitis (AR) and serum lead, but large population-based studies are currently lacking. The purpose of this study was to investigate the association between AR and serum lead levels in adult samples from the National Health and Nutrition Examination Survey (NHANES). Methods: This cross-sectional study included 1993 adults aged 20-85 years with complete inhalation allergen testing, serum heavy metal detection and model covariate information in the National Health and Nutrition Survey from 2005 to 2006. Participants were categorized into AR group and non-AR group based on self-reported allergy questionnaire and inhalation allergen-specific IgE level. The analysis was conducted using R ( http://www.R-project.org) and EmpowerStats software (www.empowerstats.com, X & Y solution.Inc.Boston MA ). Results: The mean age of the study population was 48.75 years; 43.50% of the subjects were males, and 56.50% were females. Compared to individuals with low serum lead levels, those with high serum lead levels had a 36% higher odds ratio for AR (Odds Ratio [OR]: 1.36, 95% Confidence Interval [CI]: 1.06-1.75), P = 0.0171). After adjusting for all other confounding factors, the association between serum lead levels and AR remained statistically significant (OR: 1.61, 95% CI: 1.02-2.54, P = 0.0411). Conclusions: The present cross-sectional study identified a significant correlation between AR and serum lead levels, indicating that adults with elevated serum lead concentrations are at an increased risk of developing AR. Further research is needed to confirm the validity of this association.

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Lithium promotes malignant transformation of nontumorigenic cells in vitro

Cited by 10 publications

References 44 publications

LiCl Promotes Recovery of Radiation-Induced Oral Mucositis and Dysgeusia

LiCl Promotes Recovery of Radiation-Induced Oral Mucositis and Dysgeusia

Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice

Association Between Allergic Rhinitis and Serum Lead in American Adults

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