Lithium Treatment Effects on the Neuropsychological Functioning of Patients With Bipolar I Disorder

López‐Jaramillo, Carlos; Lopera-Vásquez, Juan Pablo; Ospina‐Duque, Jorge; García, Jenny; Gallo, Aurora; Cortez, Vladimir; Palácio, Carlos; Torrent, Carla; Martínez‐Arán, Anabel; Vieta, Eduard

doi:10.4088/jcp.08m04673yel

Cited by 70 publications

(45 citation statements)

References 29 publications

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“…Literature regarding the neurocognitive effects of psychotropic medication is mixed; some studies claim that deficits are due to medication, specifically when patients are taking lithium [70]. Other medications such as risperidone and quietapine may lead to drowsiness and this may be confounded with neuropsychological deficits associated with BD too [71].…”

Section: Discussionmentioning

confidence: 98%

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Cardoso

Bauer

Meyer

et al. 2015

Curr Psychiatry Rep

130

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Bipolar disorder (BD) has been associated with impairments in a range of cognitive domains including attention, verbal learning, and mental flexibility. These deficits are increased during the acute phases of the illness and worsen over the course of BD. This review will examine the literature in relation to potential mechanisms associated with cognitive decline in BD. Scopus (all databases), Pubmed, and Ovid Medline were systematically searched with no language or year restrictions, up to January 2015, for human studies that collected cross-sectional and longitudinal cognitive data in adults with BD and matched healthy controls (HC). Selected search terms were "bipolar," "cognitive," "aging," "illness duration," "onset," and "progression." Thirty-nine studies satisfied the criteria for consideration. There is evidence that cognitive function in BD is negatively associated with features of illness progression such as number of mood episodes, illness duration, and hospitalizations. Aging does not appear to affect cognitive functioning to a greater extent than in HC. Furthermore, the small number of longitudinal studies in this field does not allow to reaching firm conclusion in terms of which sub-populations would be more prone to cognitive decline in BD. The decline in cognitive abilities over the course of the BD seems to be associated with the number of episodes and number of hospitalizations. No meaningful interaction of age and bipolar disorder has been found in terms of cognitive decline. Future large-scale longitudinal studies are necessary to confirm these findings and assist in the development of preventive interventions in vulnerable individuals.

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Section: Discussionmentioning

confidence: 98%

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Cardoso

Bauer

Meyer

et al. 2015

Curr Psychiatry Rep

130

View full text Add to dashboard Cite

show abstract

“…On the other hand, bipolar patients medicated with lithium (N=20) did not differ from those who were unmedicated (N=20) in terms of their cognitive performance 32 . This was an uncontrolled, open study; it is unclear how the patients were assigned to their treatment groups.…”

Section: Potencial Deleterious Effects Of Medication On Cognition In mentioning

confidence: 98%

Cognitive Impairment in Bipolar Disorder

Látalová¹,

Praško²,

Divéky³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…28 Although patients on lithium frequently complain of cognitive impairment, prescribing clinicians should be aware that the cognitive deficits in BD patients can, in part, be a manifestation of the disease itself rather than an adverse effect of lithium. 29 A meta-analysis of 12 studies with lithium treatment concluded that lithium's adverse effect on memory is present but limited. 30 Similarly, a prospective study conducted with 44 euthymic patients with bipolar I disorder suggested no significant difference in neurocognitive performance in patients prescribed bipolar medications in comparison to unmedicated patients.…”

Section: Cognitive Impairmentmentioning

confidence: 99%

Role of Adverse Effects in Medication Nonadherence in Bipolar Disorder

Mago

Borra

Mahajan

2014

Harvard Review of Psychiatry

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Nonadherence to medications is common and associated with poor or limited clinical outcomes in the treatment of bipolar disorder. A review of the literature discloses that adverse effects are one of the commonly reported reasons for nonadherence to mood stabilizers by patients with bipolar disorder. Nevertheless, other than such broad summaries, relatively little attention has been given to the role of adverse effects in relation to nonadherence. This review article is the first to consolidate the available data on this topic. Weight gain, perceived cognitive impairment, tremors, and sedation are the adverse effects most likely to lead to nonadherence. Further research is needed to anticipate, identify, manage, and potentially minimize the impact of adverse effects.

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Lithium Treatment Effects on the Neuropsychological Functioning of Patients With Bipolar I Disorder

Abstract: Patients with bipolar I disorder have verbal memory deficits that are not explained by medication or by lithium monotherapy, but by the condition itself.

Cited by 70 publications

References 29 publications

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Cognitive Impairment in Bipolar Disorder

Role of Adverse Effects in Medication Nonadherence in Bipolar Disorder

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