Macroscopic quantum tunneling is a fundamental phenomenon of quantum mechanics related to the actively debated topic of quantum-to-classical transition. The ability to realize macroscopic quantum tunneling affects implementation of qubit-based quantum computing schemes and their protection against decoherence. Decoherence in qubits can be reduced by means of topological protection, e.g., by exploiting various parity effects. In particular, paired phase slips can provide such protection for superconducting qubits. Here, we report on the direct observation of quantum paired phase slips in thin-wire superconducting loops. We show that in addition to conventional single phase slips that change the superconducting order parameter phase by 2π, there are quantum transitions that change the phase by 4π. Quantum paired phase slips represent a synchronized occurrence of two macroscopic quantum tunneling events, i.e., cotunneling. We demonstrate the existence of a remarkable regime in which paired phase slips are exponentially more probable than single ones. DOI: 10.1103/PhysRevX.5.021023 Subject Areas: Mesoscopics, Quantum Information, SuperconductivityDecoherence and quantum noise are primary roadblocks for large-scale implementation of quantum computing that in many cases relies on the phenomenon of macroscopic quantum tunneling [1][2][3][4][5]. Decoherence is inherently related to the collapse of macroscopic wave functions caused by various environment-induced interactions. In quantum computers, detrimental effects of decoherence can be eliminated by means of quantum error correction as originally proposed by Shor [6]. An alternative approach was suggested by Kitaev [7], who argued that the use of topologically ordered quantum systems can eliminate the burden of quantum error correction. In such systems, qubits are implemented by topologically distinct states connected by a global operation (such as braiding, in the case of anyons) that cannot be mixed by a local perturbation.Less exotic schemes of topological protection based on various parity effects in superconducting circuits have also been presented [8][9][10][11]. The crucial component of these proposals is a device that discriminates between parity-conserving and parity-violating transitions. Ideally, such a device fully suppresses the latter, thus creating well-separated parity-based sectors in the Hilbert space, which are used as a "grid" for qubit operations.Here, we focus on a multiply-connected device formed by a superconducting loop containing homogeneous superconducting nanowires. Flux states of the loop are described by the winding number (vorticity) of the superconducting phase on a path encircling the loop. Transitions between different winding number states occur through phase slips taking place in the nanowires. Realization of a parityprotected qubit requires suppression of 2π phase slips, which change the winding number by 1, and a significant amplitude of 4π phase slips, which are parity-conserving [12][13][14] events. We term them single phase s...