Littoral Cell Angioma of the Spleen

Kumar, Aman; Kindell, Daniel G.; Desai, Chirag S.

doi:10.1007/s11605-021-04980-9

Cited by 4 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, progressive enhancement from the periphery was detected when a slow-motion videotape was replayed. In contrast to previous related studies, our MRI images showed a relatively hyperintense splenic lesion on T2 signal intensity (3,4). We suggest that the difference is due to the varied content of hemosiderin in the hemophagocytic cells.…”

Section: Discussioncontrasting

confidence: 99%

Multimodality imaging findings of splenic littoral cell angioma: a case description and analysis of literature

Zeng¹,

Jia²,

Song³

et al. 2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 99%

Multimodality imaging findings of splenic littoral cell angioma: a case description and analysis of literature

Zeng¹,

Jia²,

Song³

et al. 2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

“…In contrast to littoral cell angiosarcoma and littoral cell hamangioendothelioma, LCA is generally considered to be benign, although the potential for rare malignant transformation has been considered 1 21 22. LCA has a broad age range and there may be a slight female predominance 4 5 22…”

Section: Discussionmentioning

confidence: 99%

“…LCA shows characteristic anastomosing vascular channels lined by endothelial cells, which can exhibit a papillary extension into the luminal space, resulting in irregular channels. These occasionally multinucleated cells often show evidence of haemosiderin deposition and intraluminal sloughing 5 6 27. Immunohistochemical staining is reflective of the specialised nature of littoral cells, with expression of the histiocyte-associated markers CD68, CD163 and lysozyme along with the endothelial-associated markers CD31 and von Willebrand factor.…”

Section: Discussionmentioning

confidence: 99%

“…This benign entity is diagnosed based on both histologic and immunohistologic analysis, which reveals a unique endothelial–histiocytic hybrid 1–3. While LCA is exceedingly rare, it can affect both children and adults, with a median age of approximately 50 years, and does not appear to have a gender predilection 1 4 5. Shortly after it was first described in 1991, it was found to be associated with visceral malignancy 6 7.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rare case of littoral cell angioma recognised on CT simulation for adjuvant radiation treatment for early stage breast cancer

et al. 2022

View full text Add to dashboard Cite

A 63-year-old woman with pathological anatomic/prognostic stage IA ER+/PR+/HER2- multifocal invasive mammary carcinoma with mixed ductal and lobular features of the left breast underwent lumpectomy with sentinel lymph node biopsy. During evaluation of the CT simulation for adjuvant radiation (RT) treatment planning, a liver lesion and splenomegaly were noted. A subsequent MRI abdomen revealed a large, indeterminate splenic lesion with a wide differential and a benign liver cyst. The patient ultimately underwent splenectomy, with pathology consistent with littoral cell angioma, a rare entity associated with several malignancies. At last follow-up, 7 months after completion of RT, she remained cancer free while on anastrazole and was doing well clinically.

show abstract

“…These can be associated with systemic diseases, such as Crohn disease, immune thrombocytopenic purpura, and other malignancies. 45…”

Section: Benign Lesions Epithelioid Hemangiomamentioning

confidence: 99%

Epithelioid Vascular Lesions: The Differential Diagnosis and Approach in Cytology and Small Biopsies

Tabish

2022

Advances in Anatomic Pathology

View full text Add to dashboard Cite

Vascular neoplasms are rare tumors with a multitude of clinical presentations and behavior, which make accurate identification and subclassification challenging on limited small biopsies. Within the spectrum of these lesions, the ones with epithelioid morphology, such as epithelioid hemangioendothelioma and epithelioid angiosarcoma, are particularly challenging given the morphologic overlap with nonvascular lesions and the limited cells due to hemodilution on sampling. Herein, we review the differential diagnosis of epithelioid vascular neoplasms, with a focus on the cytomorphology, differential diagnoses, and ancillary studies that pathologists should be aware of when evaluating small biopsies and aspirates, including novel translocations, and associated monoclonal immunohistochemistry antibodies, that can help in the diagnosis of some of these tumors. Awareness of these morphologic and ancillary study findings in these rare tumors will hopefully allow pathologists to recognize and render-specific diagnoses on limited samples of these challenging lesions.

show abstract

Littoral Cell Angioma of the Spleen

Cited by 4 publications

References 3 publications

Multimodality imaging findings of splenic littoral cell angioma: a case description and analysis of literature

Multimodality imaging findings of splenic littoral cell angioma: a case description and analysis of literature

Rare case of littoral cell angioma recognised on CT simulation for adjuvant radiation treatment for early stage breast cancer

Epithelioid Vascular Lesions: The Differential Diagnosis and Approach in Cytology and Small Biopsies

Contact Info

Product

Resources

About