Live attenuated measles virus vaccine induces apoptosis and promotes tumor regression in lung cancer

Zhao, Deqiang; Chen, Ping; Yang, Haijun; Wu, Yihe; Zeng, Xianwu; Zhao, Yu; Wang, Yuming; Zhao, Xia; Liu, Xiaolin; Wei, Yuquan; Li, Yuhua

doi:10.3892/or.2012.2109

Cited by 32 publications

(27 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our more recent work shows that MV-Edm utilizes mitophagy to promote viral replication by mitigating antiviral innate immune responses [14]. Interestingly, as some apoptotic characteristics have been observed in MV-Edm infected cancer cells reported by several previous studies [15-19], recent work shows that MV-Edm-induced autophagy protects malignant cells from apoptosis [11]. However, how virus-induced autophagy counteracts apoptotic pathways remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus

Mao

Jiang

et al. 2014

Oncotarget

View full text Add to dashboard Cite

Although apoptotic phenomena have been observed in malignant cells infected by measles virus vaccine strain Edmonston B (MV-Edm), the precise oncolytic mechanisms are poorly defined. In this study we found that MV-Edm induced autophagy and sequestosome 1-mediated mitophagy leading to decreased cytochrome c release, which blocked the pro-apoptotic cascade in non-small cell lung cancer cells (NSCLCs). The decrease of apoptosis by mitophagy favored viral replication. Persistent viral replication sustained by autophagy ultimately resulted in necrotic cell death due to ATP depletion. Importantly, when autophagy was impaired in NSCLCs MV-Edm-induced cell death was significantly abrogated despite of increased apoptosis. Taken together, our results define a novel oncolytic mechanism by which mitophagy switches cell death from apoptosis to more efficient necrosis in NSCLCs following MV-Edm infection. This provides a foundation for future improvement of oncolytic virotherapy or antiviral therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus

Mao

Jiang

et al. 2014

Oncotarget

View full text Add to dashboard Cite

show abstract

“…One possible mechanism may include transcription of viral genome and virus release which subsequently triggers cellular defense mechanisms causing tumor cell necrosis and apoptosis. Several studies demonstrated the induction of apoptotic tumor cell death following infection with an oncolytic measles virus [23,24,25]. Furthermore, it has been suggested that, depending on the applied virus strain, one potential mechanism of virus-mediated oncolysis may be based on overwhelming budding and release of virions from the infected tumor cell eventually leading to tumor cell lysis [26] (Figure 1A).…”

Section: Introductionmentioning

confidence: 99%

“…(A) Binding to frequently overexpressed virus receptors initiates internalization of the virus into the tumor cell. Viral nucleic acid is released and transcribed which leads to cellular antiviral defense mechanisms such as apoptosis [23,24,25] ( a ). Upon viral gene expression viral proteins are produced exploiting the cellular machinery.…”

Section: Introductionmentioning

confidence: 99%

Viral Oncolysis — Can Insights from Measles Be Transferred to Canine Distemper Virus?

Lapp¹,

Pfankuche²,

Baumgärtner³

et al. 2014

Viruses

View full text Add to dashboard Cite

Neoplastic diseases represent one of the most common causes of death among humans and animals. Currently available and applied therapeutic options often remain insufficient and unsatisfactory, therefore new and innovative strategies and approaches are highly needed. Periodically, oncolytic viruses have been in the center of interest since the first anecdotal description of their potential usefulness as an anti-tumor treatment concept. Though first reports referred to an incidental measles virus infection causing tumor regression in a patient suffering from lymphoma several decades ago, no final treatment concept has been developed since then. However, numerous viruses, such as herpes-, adeno- and paramyxoviruses, have been investigated, characterized, and modified with the aim to generate a new anti-cancer treatment option. Among the different viruses, measles virus still represents a highly interesting candidate for such an approach. Numerous different tumors of humans including malignant lymphoma, lung and colorectal adenocarcinoma, mesothelioma, and ovarian cancer, have been studied in vitro and in vivo as potential targets. Moreover, several concepts using different virus preparations are now in clinical trials in humans and may proceed to a new treatment option. Surprisingly, only few studies have investigated viral oncolysis in veterinary medicine. The close relationship between measles virus (MV) and canine distemper virus (CDV), both are morbilliviruses, and the fact that numerous tumors in dogs exhibit similarities to their human counterpart, indicates that both the virus and species dog represent a highly interesting translational model for future research in viral oncolysis. Several recent studies support such an assumption. It is therefore the aim of the present communication to outline the mechanisms of morbillivirus-mediated oncolysis and to stimulate further research in this potentially expanding field of viral oncolysis in a highly suitable translational animal model for the benefit of humans and dogs.

show abstract

“…HTLV-1 viral proteins may be used in the development of cancer vaccines for ATL [184,185]. Mouse model studies have reported that a live attenuated measles vaccine virus Hu-191 strain (MV) could effectively suppress the growth of mouse lung carcinoma, suggesting that this approach may be promising in the treatment of human advanced lung cancer [186].…”

Section: Prospects In Cancer Immunotherapymentioning

confidence: 99%

Advances and Prospects in Cancer Immunotherapy

Zhou

2014

New Journal of Science

View full text Add to dashboard Cite

Cancer immunotherapy is a promising and effective treatment modality for patients with cancers. Cytokine, anticytokine, and antibody therapies appear to be effective in treating various forms of cancer. The human papillomavirus vaccine is protective for cervical cancer, and this discovery has paved the way to the development of cancer vaccines for other forms of virus-associated cancers such as liver cancer and Merkel cell carcinoma. Clinical trials have demonstrated that adoptive cell therapy using tumorinfiltrating lymphocytes can induce tumor regression in approximately 75% of metastatic melanoma patients, suggesting the possibility of using similar technique to effectively treat breast, lung, and renal cancers in the near future. Besides, genetically engineered T cells transduced with genes encoding specific T cell receptors and chimeric antigen receptors have been shown effective in the treatment of cancer patients. These studies suggest that combination therapies are superior choices in cancer immunotherapy for patients.

show abstract

Live attenuated measles virus vaccine induces apoptosis and promotes tumor regression in lung cancer

Cited by 32 publications

References 25 publications

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus

Viral Oncolysis — Can Insights from Measles Be Transferred to Canine Distemper Virus?

Advances and Prospects in Cancer Immunotherapy

Contact Info

Product

Resources

About