Live birth after autograft of ovarian tissue cryopreserved during childhood: Figure 1

Abstract

Ovarian insufficiency is a major long-term adverse event, following the administration of a myeloablative conditioning regimen, and occurring in >80% of children and adolescents receiving such treatment for malignant or non-malignant disease. Cryopreservation of ovarian tissue is currently offered to preserve the fertility of these young patients. At least 35 live births have been reported after transplantation of cryopreserved ovarian tissue in adult patients, but the procedure remains unproven for ovarian tissue harvested at a prepubertal or pubertal age. We report here the first live birth after autograft of cryopreserved ovarian tissue in a woman with primary ovarian failure after a myeloablative conditioning regimen as part of a hematopoietic stem cell transplantation performed for homozygous sickle-cell anemia at age 14 years. This first report of successful fertility restoration after the graft of ovarian tissue cryopreserved before menarche offers reassuring evidence for the feasibility of the procedure when performed during childhood.

Hypogonadism in Children with a Previous History of Cancer: Endocrine Management and Follow-Up

“…Two recent reports suggest that this technique may be of benefit in preserving fertility in young girls [26, 27], and this will be a subject for future research.…”

Fertility preservation in Turner syndrome

“…However, it may keep its potential for restoring an endocrine function following thawing and transplantation (58). In addition, the competence of ovarian tissue in term of gametic production has recently been demonstrated with the first live birth obtained after transplantation of ovarian tissue recovered from a premenarchal girl (59). Yet, data on efficiency of this approach in girls or women with TS are lacking.…”

Pediatric and Teen Ovarian Tissue Removed for Cryopreservation Contains Follicles Irrespective of Age, Disease Diagnosis, Treatment History, and Specimen Processing Methods

“…16,46,47 Based on combined data from three centers in Europe, ovarian tissue transplant resulted in pregnancies in 11/60 cases. 16,48 However, in general, it is difficult to gauge the overall success rate of ovarian tissue transplantation because failures are rarely reported in the literature, and thus the denominator of attempted cases is largely unknown. Several in vivo transplants have occurred in pediatric patients, allowing entry into puberty.…”

“…Of note, it was recently reported that a live birth was obtained following transplantation of ovarian tissue that had been harvested from an individual and cryopreserved prior to menarche. 48 Based on the data gathered through the OC-NPC, it is clear that the use of OTC has increased substantially over the past FIG. 4.…”