Live birth rate following frozen–thawed blastocyst transfer is higher with blastocysts expanded on Day 5 than on Day 6

Ferreux, Lucile; Bourdon, Mathilde; Sallem, Amira; Santulli, Piétro; Barraud-Lange, Virginie; Foll, Nathalie Le; Maignien, Chloé; Chapron, Charles; Ziegler, Dominique de; Wolf, Jean-Philippe; Pocate-Cheriet, Khaled

doi:10.1093/humrep/dey004

Cited by 95 publications

(76 citation statements)

References 34 publications

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“…The final inclusion was 13 studies that met the selection criteria for our meta‐analysis. Hence, 23 studies were included in the following meta‐analyses . The main characteristics and assessment for risk of bias of the included studies are presented in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Hence, 23 studies were included in the following meta-analyses. 4,6,7,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] The main characteristics and assessment for risk of bias of the included studies are presented in Table 1.…”

Section: Results Of the Searchesmentioning

confidence: 99%

“…Only three studies transfer euploid blastocysts. 13,16,22 Five studies only transfer one embryo per cycle, [12][13][14]16,23 while remaining studies transfer no more than two blastocysts 11,[18][19][20]22,24,27,28 or more than two blastocysts per cycle. 29,30 The decision of when blastocyst was transferred in all included studies was dependent on the day of expansion.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Pregnancy outcomes after day 5 versus day 6 blastocyst‐stage embryo transfer: A systematic review and meta‐analysis

Wang²,

Sun

et al. 2020

J of Obstet and Gynaecol

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Aim To compare the pregnancy outcomes after day 5 blastocyst‐stage embryo transfers (BET) versus day 6 BET following vitrified‐warmed cycle and to evaluate whether the number of embryos transferred and the chromosomal status of embryo influence effect estimates. Methods A literature search (PubMed, Embase and MEDLINE) up to January 2019 was conducted to identify studies where women with day 6 BET were compared to women with day 5 BET. Only studies published in English language, on peer‐reviewed journal were considered eligible. The following subgroup analyses were performed: (i) number of embryos transferred and (ii) chromosomal status of embryo. Results From a total of 1956 articles identified, 23 observational studies were included in the meta‐analysis. We observed that day 6 BET were associated with lower implantation rate (risk ratio, RR: 1.17, 95% confidence interval, CI: 1.10–1.24), clinical pregnancy rate (RR: 1.17, 95% CI: 1.10–1.24), ongoing pregnancy rate (RR: 1.15, 95% CI: 1.07–1.24) and live birth rate (RR: 1.22, 95% CI: 1.11–1.33) than day 5 BET following vitrified‐warmed cycle. The subgroup analysis found that the superiority of day 5 BET compared with day 6 BET is influenced by the number of embryos transferred and chromosomal status of embryos. Conclusion Current evidence shows that day 5 BET is superior to day 6 BET following vitrified‐warmed cycle in clinical practice. Due to the overall low quality of available evidence, more larger and well‐conducted studies are needed to compare the pregnancy outcomes between day 5 and day 6 BET before drawing a clear conclusion.

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Section: Resultsmentioning

confidence: 99%

Section: Results Of the Searchesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Pregnancy outcomes after day 5 versus day 6 blastocyst‐stage embryo transfer: A systematic review and meta‐analysis

Wang²,

Sun

et al. 2020

J of Obstet and Gynaecol

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“…And if you believe in the results of Guzman and friends, how many cells you take will indeed influence outcomes [7]. And recovering from cryopreservation with respect to regaining the attribute of expansion also seems to be a determinant in the long-running saga of PGT-A, at least according to the study by Ferreux et al [8]. What does this come down to?…”

Section: Sydney Brennermentioning

confidence: 98%

Meddling with new technologies or amending an embryos’ potential

Albertini

2019

J Assist Reprod Genet

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“…Glycerol and sucrose as cryoprotectants are included in the most commonly used protocols [74] EG and DMSO were the cryoprotectants used in the first pregnancy reported after blastocyst vitrification [124] EG/DMSO/sucrose in open or close system are also used [97,125] Abbreviations: EG: ethylene glycol; DMSO: dimethylsulphoxide. With vitrification, the ice formation is almost eliminated since the cells and the extracellular milieu are solidified into a glass-like state [77].…”

Section: Blastocystsmentioning

confidence: 99%

Clinical Outcomes of Assisted Reproductive Techniques Using Cryopreserved Gametes and Embryos in Human Medicine

Waterstone¹,

Anastácio²,

Rodriguez‐Wallberg³

2018

Cryopreservation Biotechnology in Biomedical and Biological Sciences

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The methods of cryopreservation play a key role in assisted reproductive technique (ART) treatments, as they increase the efficacy of the treatments by allowing banking of supernumerary embryos for later use. It has been recently proposed that these methods could also increase the safety of ART treatments, by reducing complications such as ovarian hyperstimulation during early pregnancy; thus, the policy of total freeze for later differed transfer of embryos has been proposed. Also of great importance, cryopreservation of oocytes and spermatozoa has permitted gamete storage for long term facilitating practical routines such as the gamete banking for third-party reproductive treatment. In this chapter, the clinical indications and treatment outcomes will be revised and data updated on the safety of using cryopreservation methods in ART treatments.

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Live birth rate following frozen–thawed blastocyst transfer is higher with blastocysts expanded on Day 5 than on Day 6

Abstract: Not applicable.

Cited by 95 publications

References 34 publications

Pregnancy outcomes after day 5 versus day 6 blastocyst‐stage embryo transfer: A systematic review and meta‐analysis

Pregnancy outcomes after day 5 versus day 6 blastocyst‐stage embryo transfer: A systematic review and meta‐analysis

Meddling with new technologies or amending an embryos’ potential

Clinical Outcomes of Assisted Reproductive Techniques Using Cryopreserved Gametes and Embryos in Human Medicine

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