Live-Birth Rates and Multiple-Birth Risk Using In Vitro Fertilization

Abstract

Based on these data, the risk of multiple births from IVF varies by maternal age and number of embryos transferred. Embryo quality was not related to multiple birth risk but was associated with increased live-birth rates when fewer embryos were transferred.

Complications in pregnancies after in vitro fertilization and embryo transfer

“…In 2005, 35.0% of all births in the US resulting from IVF-ET were multiples, a rate 10 times higher than 3% in general population. 6 Women with IVF-conceived singletons are at increased risk of pre-eclampsia, gestational diabetes, placenta praevia, and perinatal mortality. ART singleton pregnancies also have higher relative risks of having induction of labor and Cesarean section (CS), both emergency and elective.…”

Relationship and parenthood in IVF couples with twin and singleton pregnancies compared with spontaneous singleton primiparous couples—a prospective 5-year follow-up study

“…A focus of the debate has been to reduce multiple births, with the current focus on one embryo transfer to eliminate twin births (1)(2)(3)(4). Studies on the physical health of the IVF-treated mother and the child during pregnancy, delivery, and neonatal period shows high rates of cesarean section, premature births, children small for gestational age, and an increased risk for congenital malformations (2)(3)(4)(5). The interpretation of these results show that the high frequency of multiple births and maternal age were the contributing factors; not the IVF technique itself.…”

IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis

“…Finally, discordance among blastomeres from the same embryo appears to present a significant problem in interpreting results and renders PGS for aneuploidy ineffective [48]. Large studies have shown that among women undergoing IVF, the chances of a live birth are related to the number of eggs fertilized, presumably because of the greater selection of embryos for transfer [49,50]. The fact that the embryo biopsy inevitably reduces the cohort of normal embryos available for transfer may actually Fig.…”