Live birth rates following natural cycle IVF in women with poor ovarian response according to the Bologna criteria

Polyzos, Nikolaos P.; Blockeel, Christophe; Verpoest, Willem; Vos, M. De; Stoop, Dominic; Vloeberghs, Veerle; Camus, Michel; Devroey, Paul; Tournaye, Herman

doi:10.1093/humrep/des318

Cited by 101 publications

(83 citation statements)

References 16 publications

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“…The results of our current analysis cannot easily be compared to most other studies involving poor responders, as the definition of poor responders is inconsistent among these. However, there are two more recent studies which use these latest Bologna criteria to evaluate natural cycle IVF treatment in poor responders [18,19]. The earlier one by Polyzos et al [18] concludes that poor responders do not respond well to natural cycle IVF, with ongoing pregnancy rates per cycle under 3 % in all age groups in this category.…”

Section: Discussionmentioning

confidence: 99%

“…In 2011, the Bologna criteria for poor ovarian response were established [17] to make it possible to compare different studies on this subject. Following this, a retrospective cohort trial [18] comparing poor responders, defined by the Bologna criteria, to normal responders in natural cycle IVF showed contradictory results to the studies previously stated. Also, a recent study looking at outcomes of mnIVF in poor responders, with a protocol very similar to the one used in our center, showed that this treatment yields poor outcomes in this patient population [19].…”

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Outcomes of 1503 cycles of modified natural cycle in vitro fertilization: a single-institution experience

Shaulov

Vélez

Buzaglo

et al. 2015

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

Outcomes of 1503 cycles of modified natural cycle in vitro fertilization: a single-institution experience

Shaulov

Vélez

Buzaglo

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…The review by Polyzos et al [14] suggested that pregnancy outcome in poor responder women undergoing the natural IVF were substantially low with a positive HCG rate of 4.6 % and live birth of 2.6 % per cycle. On the other hand, the study of Jonsdottir et al [54] confirmed that the live birth rate in poor responders after double embryo transfer was clinically and statistically significantly higher than after single embryo transfer with a modest increase in multiple birth rates.…”

Section: Discussionmentioning

confidence: 99%

“…However, the pregnancy rate per started cycle have been observed to be relatively low (0-18.3 %) [2,3,14,[21][22][23][24]. The cumulative pregnancy rate in the population of normal responders was estimated about 20.8 % [3] and 44 % [4] only after three and nine cycles, respectively.…”

Section: Introductionmentioning

confidence: 98%

“…The aim of controlled ovarian hyperstimulation is to reduce the cycle cancellation rate, increment the number of oocytes and top-quality embryos and ensure better results in terms of pregnancy rates [2][3][4][5]. However, in different clinical situations such as reduced ovarian reserve, previous oncologic or estrogen-dependent disease the natural cycle continue to be considered the method of choice for IVF treatment [6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study

Greco

Litwicka

Arrivi

et al. 2013

J Assist Reprod Genet

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Purpose To evaluate the role of co-transfer of embryos derived from vitrified oocytes accumulated during the previous modified natural cycles and an embryo developed from the last one as an alternative to repetitive single embryo transfer in a fresh modified natural cycle. Methods Thirty-six patients underwent ICSI procedure with three frozen natural oocytes supplemented by a fresh one obtained from the fourth modified natural cycle. Thirty-one controls received at least three consecutive single embryo transfer in a fresh modified natural cycle. Results In the study group the oocyte retrieval, survival and total fertilization rate were 73.0 %, 78.1 %, and 64.5 %, respectively. Fifty-two embryos were transferred in 29 transfers. In the control group the oocyte retrieval and fertilization rate was 77.4 % and 83.7 %, respectively. Fifty single embryo transfers were performed. Of a total 14 pregnancies obtained in the study group 10 were defined as clinical and 4 as abortions. In the control group a total of 8 single clinical pregnancies and 2 miscarriages were encountered. The overall (20.0 % vs 48.2 %) and the clinical (16.0 % vs 34.4 %) pregnancy rate were significantly higher in the study group having cumulative embryo transfer following the oocyte accumulation. Conclusions These data demonstrate that the co-transfer of embryos derived from vitrified oocytes accumulated during the previous modified natural cycles and an embryo developed from the last fresh modified natural cycle assure an excellent clinical outcome with the overall and clinical pregnancy rate significantly higher compared to the repetitive single embryo transfer in a fresh modified natural cycle.

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Utilization of Cryopreserved Oocytes in Patients With Poor Ovarian Response After Planned Oocyte Cryopreservation

Fouks,

Sakkas,

Bortoletto

et al. 2024

JAMA Netw Open

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ImportancePoor ovarian response (POR) to stimulation may impact patients’ desire or need to utilize cryopreserved oocytes for family building in the future. These findings, captured by Society for Assisted Reproductive Technology (SART) national data, underscore the need for tailored counseling and further research into the decision-making processes influencing oocyte utilization.ObjectiveTo examine the association of ovarian response to stimulation and the number of vitrified oocytes with the likelihood and timing of patients returning for oocyte utilization following planned oocyte cryopreservation (OC).Design, Setting, and ParticipantsThis cohort study used data in the SART Clinical Outcome Reporting System for patients in US fertility clinics and data was used for eligible patients who underwent planned OC from January 2014 through December 2020. Data were analyzed from November 2022 to June 2023.Main outcomes and measuresThe association between number of oocytes cryopreserved on return rate to utilize cryopreserved oocytes and the time from vitrification to warming.ResultsA total of 67 893 autologous oocyte freezing cycles were performed in the US between 2014 and 2020, among 47 363 patients (mean [SD] age, 34.5 [4.7] years). Of these, 6421 (13.5%) were classified as patients with POR, with fewer than 5 oocytes vitrified across all ovarian stimulation cycles. A total of 1203 patients (2.5%) returned for oocyte warming and utilization. The rate of return was significantly higher in the POR group, with 260 (4.0%) returning compared with 943 (2.3%) in the normal responder group (P &lt; .001). This trend was most notable in the age 30 to 34 years (warm cycle, 46 of 275 [16.7%] vs no warm cycle, 982 of 11 743 [8.4%]; P &lt; .001) and age 35 to 39 years groups (warm cycle, 124 of 587 [21.1%] vs no warm cycle, 3433 of 23 012 [14.9%]; P &lt; .001). The time elapsed from vitrification to warming was comparable between patients with POR (mean [SD], 716.1 [156.1] days) and normal responders (803.8 [160.7] days). A multivariate analysis adjusted for age, clinic region in the US, body mass index, and history of endometriosis was conducted to identify factors associated with the utilization of oocytes. The analysis revealed that having fewer than 5 oocytes vitrified was associated with higher odds of utilizing oocytes (OR, 1.52; 95% CI, 1.32-1.76).Conclusions and RelevanceThis cohort study reveals a distinct pattern in the utilization of cryopreserved oocytes among patients undergoing planned OC in the US. Despite the increase in number of patients pursuing OC, there is a notably low rate of return to utilize previously vitrified oocytes; notably, patients with POR are more likely to return, although the time to return is similar to those with normal ovarian response.

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Live birth rates following natural cycle IVF in women with poor ovarian response according to the Bologna criteria

Abstract: No funding was used. There are no competing interests to declare.

Cited by 101 publications

References 16 publications

Outcomes of 1503 cycles of modified natural cycle in vitro fertilization: a single-institution experience

Outcomes of 1503 cycles of modified natural cycle in vitro fertilization: a single-institution experience

Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study

Utilization of Cryopreserved Oocytes in Patients With Poor Ovarian Response After Planned Oocyte Cryopreservation

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