The circuit helps the sensors realize signal readout, conversion, transmission, and complex logic functions. [19][20][21] The human-machine interface (HMI) system plays the role of the application layer in the field of the IoT. [22][23][24] By presenting the sensor information to users in a simple and user-friendly interface, the HMI system enables a good user experience. [25,26] In particular, in the context of the coronavirus disease 2019 (COVID-19) pandemic, the use of smart electronic technology to achieve real-time and wireless interactive sensing is necessary. [27][28][29] Smart contact lenses (SCLs) have been employed for monitoring information regarding the eyes, including physical information (e.g., pressure and temperature) and chemical information (e.g., glucose, protein, and pH). [30][31][32][33][34] These physiological signals are closely related to human health. For example, excessive intraocular pressure (IOP) can induce glaucoma, [35] the abnormal temperature of the ocular surface can cause dry eye syndrome, [36] and excessive glucose in tears may predict diabetic retinopathy. [37] Non-invasive monitoring of human health by using SCLs will aid in better understanding of the physiological state of the eyes and even the body; subsequently, effective measures can be employed in a timely manner for the early prevention or treatment of certain diseases. As personal health information can be monitored in real-time by using SCLs, patients no longer need to go to the hospital or rely on large medical equipment. [38][39][40][41][42] Therefore, the development of SCL devices in view of the rapid advances in IoT technology is an important research topic.In this review, we focus on the latest progress and prospects of integrated biosensors, circuits, and HMI systems on SCLs under the background of the rapid development of the IoT technology, as shown in Figure 1. First, we discuss the integration of biosensors on SCLs for physiological information monitoring of the eyes, including IOP monitoring, corneal sensing, color signals sensing, tear pH monitoring, and glucose sensing. Next, we focus on wireless communication circuits integrated into SCLs, which have different functions, such as physiological signal sensing circuits, sensing circuits for disease treatment, and circuits for power supply. Furthermore, we summarize SCLs used in the HMI system. WhetherThe rapid development of the Internet of Things (IoT) technology endows some traditional devices with intelligent functions. Compared with traditional contact lenses used for correcting vision or beautifying the eyes, smart contact lenses (SCLs) are developed to monitor some physiological information of the eye. Sculls can be used to continuously monitor eye diseases noninvasively in real-time. As a personal electronic device, SCs can aid people in understanding their physical condition better without affecting their personal life. This review mainly discusses the development direction and problems associated with sculls from the perspective of the IoT. SCs c...