Live Donor Liver Transplantation for Acute Liver Failure

Kilic, Murat; Ünal, Aydın; Noyan, Ayşın; Arıkan, Çiğdem; Aydoğdu, Sema; Akyıldız, Murat; Karasu, Zeki; Zeytunlu, Murat; Alper, Mehmet; Batur, Yücel

doi:10.1097/01.tp.0000276987.55382.e2

Cited by 36 publications

(22 citation statements)

References 18 publications

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“…Of 16 patients who deferred LDLT, only 1 was transplanted, whereas 15 died on the DDLT waiting list [28]. LDLT and DDLT were compared in a retrospective cohort of Turkish adults and children with ALF [29]. LDLT recipients had increased 1-year survival (79% vs 58%) and decreased mean waiting times (2 vs 5 days) compared to DDLT recipients [29].…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Living Versus Deceased Donor Liver Transplantation for Acute Liver Failure in the United States

Urrunaga¹,

Rachakonda²,

Magder³

et al. 2014

Transplantation Proceedings

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Clinical outcomes for living donor liver transplantation (LDLT) for acute liver failure (ALF) in the United States remain to be determined. To address this gap in knowledge, we examined post–liver transplantation outcomes of adults with ALF undergoing LDLT and deceased donor liver transplantation (DDLT) in the United States. We analyzed Organ and Procurement and Transplantation Network data for adults with ALF who were listed for liver transplantation as status 1 or 1A and who underwent LDLT (N = 21) or DDLT (N = 2316) between October 1987 and April 2011. We found no strong evidence that the survival probabilities for adults with ALF who underwent LDLT were inferior to those who underwent DDLT (P = .764). In adults with ALF who underwent LDLT, 1- and 5-year survival probabilities were both 71%; for DDLT these probabilities were 79% and 71%, respectively. In adults with ALF, 1- and 5-year liver graft survival probabilities, respectively, were 62% and 57% for LDLT, and 74% and 66% for DDLT. In these series of adults with ALF who were listed as status 1 or 1A, patient and graft survival rates for LDLT were similar to those for DDLT. Our findings suggest that if deceased donor livers are unavailable, LDLT is an acceptable option in experienced centers for adults with ALF.

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Section: Discussionmentioning

confidence: 99%

Outcomes of Living Versus Deceased Donor Liver Transplantation for Acute Liver Failure in the United States

Urrunaga¹,

Rachakonda²,

Magder³

et al. 2014

Transplantation Proceedings

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“…Patients suffering from ALF have a dismal prognosis without LT (21). In addition, the need for liver transplant is particular urgent in this patient group since the disease can progress within hours to coma and brain death.…”

Section: Discussionmentioning

confidence: 99%

Live Donor Liver Transplantation: A Valid Alternative for Critically Ill Patients Suffering From Acute Liver Failure

Goldaracena

Spetzler

Marquez

et al. 2015

American Journal of Transplantation

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“…Previous publications from pediatric liver transplant centers in Turkey also reported low transplant rates in pediatric ALF patients from deceased donors. 13,14 As shown in our report, in 16 pediatric AFL patients who required emergency transplant, a liver did not become available from the deceased donor pool after patients had been added to the wait list in the organ sharing system. A suitable living donor was found for 12 patients.…”

Section: Discussionmentioning

confidence: 92%

“…After this report, many centers reported their successful outcomes of living-donor liver transplant in pediatric ALF patients. 1,[13][14][15] In Turkey, deceased donor donation rates are low. According to the Turkish Ministry of HealthNational Organ and Tissue Transplantation System, the deceased donor donation rate was 3 to 4.8 donors per 1 million people between 2005 and 2014.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Yankol

Ertuğrul²,

Kanmaz³

et al. 2016

Exp Clin Transplant

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Objectives: Acute liver failure is a rapidly progressive and life-threatening disease in children, whose clinical features differ from those of adults. Materials and Methods: This is a review of a single center's experience with pediatric acute liver failure in a region with insufficient deceased donor support. The study is a retrospective review and analysis of 22 pediatric patients with acute liver failure between January 2007 and May 2013. Results: The cause of acute liver failure was indeterminate in 45.4% of cases. Listing for liver transplant was required in 72.7% of patients, whereas 27.3% developed spontaneous remission. In the patients placed on the liver transplant wait list, 75% underwent liver transplant and 25% died before undergoing liver transplant. The presence of ascites, high-grade encephalopathy, and laboratory findings including high lactate dehydrogenase and phosphorous levels and international normalized ratio were significant parameters in selecting patients needing liver transplants. All liver transplants were from living donors. One-and 3-year patient survival rates after liver transplant were 75% and 75%. No serious donor complications occurred. Conclusions: Living-donor liver transplant may be the only option to save the lives of pediatric patients with acute liver failure, especially in regions with insufficient deceased-donor support. Timely referral to a multidisciplinary transplant center, expedient evaluation of living donors, and appropriate timing of transplant are crucial for a successful outcome.

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Live Donor Liver Transplantation for Acute Liver Failure

Abstract: LDLT offers a safe and effective modality of treatment for ALF for both pediatric and adult patients to overcome the problem of organ shortage especially in countries where the chance of receiving an organ from a deceased donor is low.

Cited by 36 publications

References 18 publications

Outcomes of Living Versus Deceased Donor Liver Transplantation for Acute Liver Failure in the United States

Outcomes of Living Versus Deceased Donor Liver Transplantation for Acute Liver Failure in the United States

Live Donor Liver Transplantation: A Valid Alternative for Critically Ill Patients Suffering From Acute Liver Failure

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