Live fast, die soon: cell cycle progression and lifespan in yeast cells

Jiménez, Javier; Bru, Samuel; Ribeiro, Mariana P.C.; Clotet, Josep

doi:10.15698/mic2015.03.191

Cited by 22 publications

(21 citation statements)

References 37 publications

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“…Notably, many insights obtained in yeast have proven to be transferable to higher eukaryotes. Indeed, over the past decades, yeast studies have unveiled individual gene functions as well as gene and protein interactions, and have instrumentally contributed to the understanding of fundamental cellular processes such as eukaryotic cell cycle control 10 11 12 13 14 15 , autophagy 16 17 18 19 , mitochondrial function 20 21 , including mitochondrial import 22 23 24 25 , protein degradation 26 , vesicle fusion 27 28 , genetic instability 29 30 , epigenetic control 31 32 , metabolic regulation 33 34 35 , or cellular nutrient sensing 36 .…”

Section: Introductionmentioning

confidence: 99%

Guidelines and recommendations on yeast cell death nomenclature

Carmona-Gutiérrez¹,

Bauer²,

Zimmermann³

et al. 2018

Microb Cell

163

154

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Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death routines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the authors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the progress of this vibrant field of research.

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Section: Introductionmentioning

confidence: 99%

Guidelines and recommendations on yeast cell death nomenclature

Carmona-Gutiérrez¹,

Bauer²,

Zimmermann³

et al. 2018

Microb Cell

163

154

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“…A common target of anti-aging molecules is the regulation of cell growth/proliferation (de Cabo et al. 2014 ; Jimenez, Ribeiro and Clotet 2015 ). This is not surprising, since growth signaling has been implicated in aging progression by promoting ROS generation (Weinberger et al.…”

Section: Conserved Mechanisms Of Anti-aging Compounds In Yeastmentioning

confidence: 99%

Yeast as a tool to identify anti-aging compounds

Zimmermann

Hofer

Pendl

et al. 2018

FEMS Yeast Research

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In the search for interventions against aging and age-related diseases, biological screening platforms are indispensable tools to identify anti-aging compounds among large substance libraries. The budding yeast, Saccharomyces cerevisiae, has emerged as a powerful chemical and genetic screening platform, as it combines a rapid workflow with experimental amenability and the availability of a wide range of genetic mutant libraries. Given the amount of conserved genes and aging mechanisms between yeast and human, testing candidate anti-aging substances in yeast gene-deletion or overexpression collections, or de novo derived mutants, has proven highly successful in finding potential molecular targets. Yeast-based studies, for example, have led to the discovery of the polyphenol resveratrol and the natural polyamine spermidine as potential anti-aging agents. Here, we present strategies for pharmacological anti-aging screens in yeast, discuss common pitfalls and summarize studies that have used yeast for drug discovery and target identification.

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“…Asam fosfat adalah asam utama yang digunakan dalam industri kimia yang dihasilkan dengan hidrasi fosfor petoksida. Asam fosfat komersial memiliki 75-85% (56)(57)(58)(59)(60)(61) . Asam fosforik merupakan molekul yang sangat sekali mempunyai kutub, dan sangat larut dalam air.…”

Section: Pendahuluanunclassified

Asam Posfat (H3PO4): Ionic Transformation of Phosphoric Acid in Aqueous Solution

Warlinda¹,

Zainul²

2019

Preprint

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Asam fosfat merupakan merupakan asam mineral anorganik yang memiliki rumus kimia H3PO4. Asam fosfat juga dikenal pula sebagai asam ortofosfat atau asam fosfat(V). Asam fosfat berwujud zat padat dengan T.D =280°C dan T.L = 44,1°C dan pada temperatur tinggi (t =1040 °C), mengalami disosiasi. Sumber yang pada umumnya dari asam fosfat adalah larutan air 85%.Kelarutan senyawa asam fosfat menyebabkan terjadinya interaksi suatu sistem biologis yang mengamati sifat interaksi dari masing-masing molekul merupakan suatu proses yang sangat kompleks dan akan sulit jika melalui percobaan. Penelitian ini bertujuan untuk menganalisis interaksi molekuler dan kinetik dari senyawa asam fosfat. Metode yang digunakan adalah dengan pemodelan menggunakan chem office serta melalui jurnal hasil penelitian mengenai asam fosfat. Sifat-sifat termokimia dari senyawa asam fosfat dalam fase liquid ∆𝑓𝐻0=-3055 kJ /mol,𝑆0 = 95,54 J/molK, dan ∆𝐺0= -3015 kJ/molK. Interaksi atau transformasi suatu ion dapat dilihat dari pengaruh aspek sifat termodinamika senyawa ion (asam fosfat) dalam suatu larutan melalui perhitungan viskositas, kecepatan hanyut,dan mobilitas yang akan mempengaruhi tingkat konduktivitas senyawa asam fosfat. Asam fosfat memiliki kecepatan hayut 0,41508 𝑉/𝑐𝑚, konduktivitas listrik 9,2 Ms/cm untuk persen massa 0,5%, mobilitas relative ion H+ dan PO43- adalah 1,62 dan 8,40 serta tingkat viskositas 3.86 mPa·s. Berdasarkan hasil kalkulasi dari Chem 3D, energy kinetik rotasi atau MM2 Dinamycs rata-rata dari asam fosfat sekitar 0.0278 dengan MM2 minimization total 3.4350

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Live fast, die soon: cell cycle progression and lifespan in yeast cells

Cited by 22 publications

References 37 publications

Guidelines and recommendations on yeast cell death nomenclature

Guidelines and recommendations on yeast cell death nomenclature

Yeast as a tool to identify anti-aging compounds

Asam Posfat (H3PO4): Ionic Transformation of Phosphoric Acid in Aqueous Solution

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