Lived experiences of women reporting fatigue during PARP inhibitor maintenance treatment for advanced ovarian cancer: A qualitative study

Poort, Hanneke; Fenton, Anny; Thompson, Embree; Dinardo, Margaret; Liu, Joyce F.; Arch, Joanna J.; Wright, Alexi A.

doi:10.1016/j.ygyno.2020.10.034

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…Qualitative studies in other conditions such as chronic fatigue syndrome and cancer have likewise reported changed self‐identity, ‘invisibility’ and anxiety due to fatigue 30,31 . Qualities of cancer fatigue, including feeling different to ‘normal tiredness’, involving the whole body, cognitive effects and patterns of fatigue 32 are strikingly similar to our findings with MPN.…”

Section: Discussionsupporting

confidence: 83%

“…Qualitative studies in other conditions such as chronic fatigue syndrome and cancer have likewise reported changed self-identity, 'invisibility' and anxiety due to fatigue. 30,31 Qualities of cancer fatigue, including feeling different to 'normal tiredness', involving the whole body, cognitive effects and patterns of fatigue 32 are strikingly similar to our findings with MPN. A meta-synthesis of fatigue studies in rheumatoid arthritis highlighted the difficulties of communicating one's fatigue to family and friends, with similar physical, emotional, cognitive and social impacts to MPN fatigue to the current study.…”

Section: Thematic Analysis Of Transcriptssupporting

confidence: 83%

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Disabled, invisible and dismissed—The lived experience of fatigue in people with myeloproliferative neoplasms

et al. 2022

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Background Myeloproliferative neoplasms (MPNs) are rare haematological cancers. Several studies report the most common MPN symptom leading to reduced quality of life is fatigue. Yet, how fatigue affects the lives of people with MPN is not well described. Aims The purpose of this qualitative study is to better understand the lived experience of fatigue associated with MPN. Methods and results People with MPN who had experienced fatigue were invited to complete an online survey and if eligible, then to participate in semi‐structured interviews and focus groups, exploring their experiences of fatigue. Thematic analysis of interview transcripts by two researchers produced themes describing the lived experience of fatigue. Twenty‐three people with MPN participated in seven interviews and four focus groups. Qualitative data revealed how fatigue significantly affected participants' experiences of functional, social, family and emotional wellbeing. Participants reported that fatigue was infrequently acknowledged or addressed by health professionals, and a lack of information or support to manage their fatigue. Four themes including 12 sub‐themes describe the experience of fatigue in MPN: (1) the distress of the MPN diagnosis, (2) sensations of fatigue, (3) daily life and emotional burden with fatigue and (4) how people managed their fatigue with limited guidance. Conclusion Fatigue in MPN is common, debilitating and distressing. It affects all aspects of health, wellbeing and life. Health professionals could affect patients' lives substantially by acknowledging and understanding fatigue in MPN, including contributing factors and potential opportunities for management. More systematic data describing the causes and management of MPN fatigue is needed.

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Section: Discussionsupporting

confidence: 83%

Section: Thematic Analysis Of Transcriptssupporting

confidence: 83%

Disabled, invisible and dismissed—The lived experience of fatigue in people with myeloproliferative neoplasms

et al. 2022

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“…Although treatment-related fatigue represents a common class effect of PARPis, some subjective and objective underlying causes not directly related to these drugs could also be contributing to fatigue, such as prior chemotherapy, anemia, poor nutrition, emotional distress, or insomnia ( Table 4 ) ( 29 ). Fatigue is a distressing symptom that negatively impacts patients’ quality of life and can provoke a lack of adherence ( 30 ). Patients should be informed of the expected patterns of fatigue, aiming to facilitate patients’ adaptation to the ongoing treatment.…”

Section: Management Of Adverse Events In Clinical Practice (Beyond Dr...mentioning

confidence: 99%

Safety of bevacizumab and olaparib as frontline maintenance therapy in advanced ovarian cancer: expert review for clinical practice

Romero,

Guerra,

Madariaga

et al. 2024

Front. Oncol.

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Olaparib, a poly(ADP-ribose) polymerase inhibitor, in combination with the antiangiogenic agent bevacizumab, is approved as maintenance therapy for patients with newly diagnosed stage III or IV epithelial ovarian cancer who have homologous recombination deficient tumors with a deleterious or suspected deleterious BRCA mutation and/or genomic instability based on the long-lasting survival benefit observed in the PAOLA-1 trial. Despite treatment with olaparib and bevacizumab showing an acceptable safety profile, the rate of discontinuations due to adverse events was relatively high, and toxicity related to this regimen may restrict its clinical use. Proper management of olaparib/bevacizumab-related adverse events is important for the improvement of quality of life and maximization of the efficacy of maintenance therapy. Here, we summarize the safety results of the PAOLA-1 study, focusing on treatment discontinuation reasons and adverse event profiles. We sought to shed light on toxicity monitoring and prevention, providing concise recommendations for the clinical management of the most relevant side effects.

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Cluster analysis of social isolation in gynecologic cancer patients: A cross‐sectional survey

Zhang,

Zhan,

Huang

et al. 2024

Intl J Gynecology & Obste

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ObjectiveTo identify the distinct clusters of social isolation among gynecologic cancer patients and analyze the predictive factors associated with each cluster.MethodsA total of 463 patients diagnosed with gynecologic cancer were recruited from three tertiary hospitals between November 2021 and March 2023. Using a two‐step cluster analysis, participants were categorized into clusters based on social isolation scales. Multinomial logistic regression was then employed to predict factors influencing the identified clusters.ResultsSocial isolation in gynecologic cancer patients manifested in four distinct clusters: mild social isolation subgroup (13.8%), moderate social isolation subgroup (32.0%), severe isolation subgroup (33.5%), and high social isolation (20.70%). Multivariate logistic regression analysis revealed that cognitive emotional regulation, social support, negative emotions, endometrial cancer, and disease recurrence or metastasis were significant predictive factors for the identified social isolation clusters (P < 0.05).ConclusionsThe study underscored the heterogeneity in the social isolation characteristics of gynecologic cancer patients. Consequently, healthcare professionals should prioritize the identification of potential high‐risk groups and devise personalized interventions to prevent and mitigate the occurrence of social isolation.

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Lived experiences of women reporting fatigue during PARP inhibitor maintenance treatment for advanced ovarian cancer: A qualitative study

Cited by 7 publications

References 36 publications

Disabled, invisible and dismissed—The lived experience of fatigue in people with myeloproliferative neoplasms

Disabled, invisible and dismissed—The lived experience of fatigue in people with myeloproliferative neoplasms

Safety of bevacizumab and olaparib as frontline maintenance therapy in advanced ovarian cancer: expert review for clinical practice

Cluster analysis of social isolation in gynecologic cancer patients: A cross‐sectional survey

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