Based on data from 10 coastal regions in China, this study establishes an evaluation index system for marine fisheries using the theoretical framework of the DPSR model. The entropy method is used to calculate the degree of marine fisheries vulnerability in each region of China from 2009 to 2018. The spatial Durbin model (SDM) is also used to analyze the influencing factors and spatial spillover effects of marine fisheries vulnerability from four perspectives of economic efficiency, industrial structure, environmental regulation, and ecological pollution. The results show significant positive direct effects between the economic efficiency, ecological pollution, and vulnerability of marine fisheries. At the same time, there are significant negative effects between the industrial structure, environmental regulation, and vulnerability of marine fisheries. In terms of spatial spillover effects, economic efficiency, environmental regulation, and ecological pollution show positive spatial spillover effects, while the industrial structure shows negative spatial spillover effects. These findings provide a theoretical basis for the sustainable development of marine fisheries in China.