Liver 5'-deiodinase activity is modified in rats under restricted feeding schedules: evidence for post-translational regulation

Aceves, Carmen; Escobar, Carolina; Rojas-Huidobro, R; Vázquez‐Martínez, Olivia; Martínez-Merlos, Teresa; Aguilar‐Roblero, Raúl; Dı́az-Muñoz, Mauricio

doi:10.1677/joe.0.1790091

Cited by 22 publications

(18 citation statements)

References 33 publications

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“…In our experiment, however, we observed a higher plasma fT3 concentration in younger rats, which could reflect higher DIO1 activity in this group (Lachowicz et al, 2014). On the other hand, rodent liver DIO1 activity was reduced by 40% calorie restriction introduced for 30 days (Araujo et al, 2008) or for 25 days (Araujo et al, 2009) and by 24-h fasting (Aceves et al, 2003), or was not changed by 24-h fasting (Boelen et al, 2012), while DIO1 mRNA remained unaffected by 24-h fasting (Aceves et al, 2003;Boelen et al, 2012). On the other hand, an increase in liver DIO3 mRNA expression was found after 24-h fasting (Boelen et al, 2012).…”

Section: Discussioncontrasting

confidence: 67%

Interdependence of the peripheral metabolism of glucocorticoids and thyroid hormones under calorie deficit in rats at different ages

et al. 2014

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Section: Discussioncontrasting

confidence: 67%

Interdependence of the peripheral metabolism of glucocorticoids and thyroid hormones under calorie deficit in rats at different ages

et al. 2014

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“…Corticosterone is known to decrease liver deiodinase (Aceves et al 2003, Araujo et al 2009, and the corticosterone levels were higher in the animals of the Bro-Sed group; exercise appeared to normalize corticosteronemia in these animals. An acute bout of exercise appears to influence thyroid hormone concentrations (Fortunato et al 2008, CasimiroLopes et al 2012, a finding that was also observed in chronically exercised mice (Katzeff et al 1988).…”

Section: Discussionmentioning

confidence: 89%

Effects of running wheel training on adult obese rats programmed by maternal prolactin inhibition

Boaventura

Casimiro-Lopes

Pazos‐Moura

et al. 2013

Journal of Endocrinology

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The inhibition of maternal prolactin production in late lactation leads to metabolic syndrome and hypothyroidism in adult offspring. Physical training is a therapeutic strategy that could prevent or reverse this condition. We evaluated the effects of a short-duration low-intensity running wheel training program on the metabolic and hormonal alterations in rats. Lactating Wistar rats were treated with bromocriptine (Bro, 1 mg twice a day) or saline on days 19, 20, and 21 of lactation, and the training of offspring began at 35 days of age. Offspring were divided into sedentary and trained controls (C-Sed and C-Ex) and sedentary and trained Bro-treated rats (Bro-Sed and Bro-Ex). Chronic exercise delayed the onset of weight gain in Bro-Ex offspring, and the food intake did not change during the experimental period. At 180 days, visceral fat mass was higher (C46%) in the Bro-Sed offspring than in C-Sed and Bro-Ex rats. As expected, running capacity was higher in trained animals. Most parameters observed in the Bro-Sed offspring were consistent with hypothyroidism and metabolic syndrome and were reversed in the Bro-Ex group. Chronic exercise did not influence the muscle glycogen in the C-Ex group; however, liver glycogen was higher (C30%) in C-Ex group and was unchanged in both Bro offspring groups. Bro-Ex animals had higher plasma lactate dehydrogenase levels, indicating skeletal muscle damage and intolerance of the training program. Low-intensity chronic training is able to normalize many clinical aspects in Bro animals; however, these animals might have had a lower threshold for exercise adaptation than the control rats.

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“…FEO expression promotes dramatic changes in the physiology and metabolic performance of the liver [11,14,15]: During the FAA (before food access), there is a prevalence of oxidized cytoplasmic and mitochondrial redox states, an increase in adenine nucleotides levels, an enhanced mitochondrial capacity to generate ATP, and a hypothyroidal-like condition that is not systemic but exclusively hepatic. In contrast, after feeding the hepatic redox state becomes reduced in both cytoplasmic and mitochondrial compartments, the levels of ATP decline, and the level of T 3 within the liver increases.…”

Section: Introductionmentioning

confidence: 99%

Daytime food restriction alters liver glycogen, triacylglycerols, and cell size. A histochemical, morphometric, and ultrastructural study

Dı́az-Muñoz¹,

Vázquez‐Martínez²,

Báez-Ruíz³

et al. 2010

Comp Hepatol

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BackgroundTemporal restriction of food availability entrains circadian behavioral and physiological rhythms in mammals by resetting peripheral oscillators. This entrainment underlies the activity of a timing system, different from the suprachiasmatic nuclei (SCN), known as the food entrainable oscillator (FEO). So far, the precise anatomical location of the FEO is unknown. The expression of this oscillator is associated with an enhanced arousal prior to the food presentation that is called food anticipatory activity (FAA). We have focused on the study of the role played by the liver as a probable component of the FEO. The aim of this work was to identify metabolic and structural adaptations in the liver during the expression of the FEO, as revealed by histochemical assessment of hepatic glycogen and triacylglycerol contents, morphometry, and ultrastructure in rats under restricted feeding schedules (RFS).ResultsRFS promoted a decrease in the liver/body weight ratio prior to food access, a reduction of hepatic water content, an increase in cross-sectional area of the hepatocytes, a moderate reduction in glycogen content, and a striking decrease in triacylglyceride levels. Although these adaptation effects were also observed when the animal displayed FAA, they were reversed upon feeding. Mitochondria observed by electron microscopy showed a notorious opacity in the hepatocytes from rats during FAA (11:00 h). Twenty four hour fasting rats did not show any of the modifications observed in the animals expressing the FEO.ConclusionsOur results demonstrate that FEO expression is associated with modified liver handling of glycogen and triacylglycerides accompanied by morphometric and ultrastructural adaptations in the hepatocytes. Because the cellular changes detected in the liver cannot be attributed to a simple alternation between feeding and fasting conditions, they also strengthen the notion that RFS promotes a rheostatic adjustment in liver physiology during FEO expression.

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Liver 5'-deiodinase activity is modified in rats under restricted feeding schedules: evidence for post-translational regulation

Cited by 22 publications

References 33 publications

Interdependence of the peripheral metabolism of glucocorticoids and thyroid hormones under calorie deficit in rats at different ages

Interdependence of the peripheral metabolism of glucocorticoids and thyroid hormones under calorie deficit in rats at different ages

Effects of running wheel training on adult obese rats programmed by maternal prolactin inhibition

Daytime food restriction alters liver glycogen, triacylglycerols, and cell size. A histochemical, morphometric, and ultrastructural study

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