Liver Abnormalities Associated with Celiac Sprue

Hypertransaminasemia in Newly Diagnosed Pediatric Patients With Celiac Disease

“…Of the 28 children with elevated transaminases, 15 had normal levels after a mean duration of 210 days on a GFD. These findings are consistent with prior studies that found most pediatric and adult patients normalize their liver enzymes within 1 year on treatment (5,6,10,11,14). In the remaining 6 children, ALT/AST levels decreased but did not return to normal.…”

“…Liver abnormalities have been described in adults and children with celiac disease as early as 1977 and 1978, respectively (3,4). More studies and meta-analyses report hypertransaminasemia in 9% to 42% of adult patients with CD and 24% to 40% of pediatric patients with CD (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). In addition, the reported pooled prevalence of CD in patients with cryptogenic hypertransaminasemia is 4% in adults and 1.8% in children (16,18).…”

Celiac, Fatty Liver, and Pancreatic Insufficiency

“…In two recent reports, approximately 9% of patients with idiopathic hypertransamiasemia were found to have celiac disease (16,17). The abnormal transaminase level disappears on a gluten‐free diet (14,15,18). In one series, 60 of 67 patients with celiac disease and abnormal liver enzymes had normal levels on a gluten‐free diet (15).…”

“…It is well known that prevalence of celiac disease is increased in the patients with insulin‐dependent diabetes mellitus (IDDM), ranging from 3% to 7%(11–13). Adults with celiac disease commonly have liver enzyme abnormalities (14,15), and celiac disease is common among patients with idiopathic hypertransaminasemia (16,17). It is believed that the liver enzyme abnormalities are caused by hepatic steatosis (15,18).…”

Association between primary biliary cirrhosis and coeliac disease Primary biliary cirrhosis and coeliac disease: a study of relative prevalences Reply

“…Our experience of screening patients with coeliac disease for PBC was less productive 4. Of the 129 patients with coeliac disease screened prospectively for liver disease at the time of diagnosis, none had serum antimitochondrial antibodies.…”