2006
DOI: 10.1007/s10354-006-0348-8
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Liver, Alcohol and Gender

Abstract: Gender differences in alcohol-induced liver injury have been well described. Females develop alcoholic liver injury more rapidly and have a lower alcohol toxic threshold than men. The mechanism for this difference is poorly characterized, differences in first-pass metabolism in the stomach, or elimination rate, or alcohol distribution volume in the body have been suggested. In addition, estrogen has a major influence on the susceptibility of Kupffer cells to gut-derived LPS resulting in increased proinflammato… Show more

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Cited by 34 publications
(25 citation statements)
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“…This is relevant as most of the hairdressers are women. Moreover, the limit values do not consider gender differences although men and women have different metabolism for several compounds (Sato 1993;Kenyon et al 1996;Muller 2006) The compounds measured in this study were numerous. We also found a large number of substances when we looked at the compounds present in the dye products used.…”
Section: Discussionmentioning
confidence: 98%
“…This is relevant as most of the hairdressers are women. Moreover, the limit values do not consider gender differences although men and women have different metabolism for several compounds (Sato 1993;Kenyon et al 1996;Muller 2006) The compounds measured in this study were numerous. We also found a large number of substances when we looked at the compounds present in the dye products used.…”
Section: Discussionmentioning
confidence: 98%
“…The brief discussion provided earlier regarding female metabolism of ETOH highlighted gender differences in BAC due to body composition and gender differences in gastric first-pass metabolism (Frezza et al 1990). Additionally, there are also suggested gender differences in ADH activity, effects of hormonal profiles on ETOH metabolism, and other gender differences related to ETOH metabolism that warrant further research (Mancinelli et al 2006;Muller 2006). Especially notable is the relative paucity of alcohol-related research in female athletes, given the clear indication of the rising rates of use and abuse in this population and the aforementioned gender differences in metabolism.…”
Section: Alcohol and Athletics: Con-sumption Patterns And Health And mentioning
confidence: 99%
“…In this step of the research the combined effect of the estrogen presence and alcohol exposure was avoided. Several studies show that gender difference to the toxic effects of alcohol exist and that estrogens could be one of the sources of higher susceptibility in females to alcohol (Muller, 2006). It is possible that the differences observed in the present research, that demonstrated that alcohol abuse is more dangerous that estrogen deficiency for osteoblasts, should be even more severe if female animals (with estrogen) exposed to alcohol were used as donor for EE-OB but the research on this topic is necessary.…”
Section: Discussionmentioning
confidence: 72%