Liver and kidney diseases

Wong, Florence

doi:10.1016/s1089-3261(02)00053-3

Cited by 15 publications

(9 citation statements)

References 159 publications

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“…Aspirin is another analgesic drug that can cause dose-related liver damage and renal failure in susceptible patients. Of special interest is the association of aspirin, used to treat symptoms of influenza or varicella, with Reye's syndrome [27,37] . The mechanism of renal damage is due to cyclooxygenase inhibition thereby preventing the production of vasodilatory prostaglandins.…”

Section: Atnmentioning

confidence: 99%

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Acute renal dysfunction in liver diseases

Betrosian¹

2007

WJG

116

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Renal dysfunction is common in liver diseases, either as part of multiorgan involvement in acute illness or secondary to advanced liver disease. The presence of renal impairment in both groups is a poor prognostic indicator. Renal failure is often multifactorial and can present as pre-renal or intrinsic renal dysfunction. Obstructive or post renal dysfunction only rarely complicates liver disease. Hepatorenal syndrome (HRS) is a unique form of renal failure associated with advanced liver disease or cirrhosis, and is characterized by functional renal impairment without significant changes in renal histology. Irrespective of the type of renal failure, renal hypoperfusion is the central pathogenetic mechanism, due either to reduced perfusion pressure or increased renal vascular resistance. Volume expansion, avoidance of precipitating factors and treatment of underlying liver disease constitute the mainstay of therapy to prevent and reverse renal impairment. Splanchnic vasoconstrictor agents, such as terlipressin, along with volume expansion, and early placement of transjugular intrahepatic portosystemic shunt (TIPS) may be effective in improving renal function in HRS. Continuous renal replacement therapy (CRRT) and molecular absorbent recirculating system (MARS) in selected patients may be life saving while awaiting liver transplantation.

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Section: Atnmentioning

confidence: 99%

“…Precipitating factors include spontaneous bacterial peritonitis (SBP), major surgical procedures, and acute alcoholic hepatitis. It follows a fulminant course with development of oliguria, encephalopathy, and marked hyperbilirubinemia, and is associated with very poor prognosis, with death occur ring within 1 mo after presentation [27,36] .…”

Section: Hrsmentioning

confidence: 99%

Acute renal dysfunction in liver diseases

Betrosian¹

2007

WJG

116

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“…Hyperbilirubinemia may contribute to the reduction in total peripheral vascular resistance and in renal blood flow due to left ventricular dysfunction [24]. MAKI may be developed by hyperbilirubinemia-induced overactive vasoconstriction of renal vasculature [25, 26]. It typically is ‘biphasic’, with an unconjugated component resulting from the excessive hemolysis and a conjugated element resulting from cholestasis [27, 28].…”

Section: Discussionmentioning

confidence: 99%

Predictors of <i>Plasmodium vivax</i> Malaria-Induced Nephropathy in Young Korean Men

Chung

Lee²,

Lee³

et al. 2008

Nephron Clin Pract

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Background:Plasmodium vivax malaria accounts for more than half of all malaria cases in Asia and Latin America. Despite the high prevalence of disease caused by this parasite, research into its effects (especially its renal effect) has lagged disproportionately. To investigate predictors of vivax malaria-induced nephropathy, we analyzed the cases of vivax malaria-induced nephropathy in young Korean men. Methods: This was a retrospective analysis of P. vivax patients with acute nephropathy (all males, n = 75), defined by an absolute increase in serum creatinine of 0.3 mg/dl or more (equal to an estimated glomerular filtration rate (eGFR) <80 ml/min) (group 1, n = 31) or proteinuria (group 2, n = 44), between January 2004 and December 2007. The eGFR was calculated using a simplified Modification of Renal Disease (MDRD) equation. None of the patients had a history of traveling abroad, drug abuse or blood transfusion. The clinical manifestations, laboratory abnormalities and predictors of nephropathy were reviewed. Results: Out of 398 cases of vivax malaria, 75 patients (all males) suffered from to vivax malaria-induced acute nephropathy. The mean age of the patients who were divided into two groups was 22.8 ± 3.7 and 21.6 ± 1.8 years, respectively (p = 0.089). In group 1, the total serum bilirubin significantly correlated with serum creatinine and eGFR (p = 0.004 and 0.035, correlation coefficient = 0.508 and –0.387, respectively). In group 2, 24-hour proteinuria significantly correlated with hemoglobin (p = 0.004, correlation coefficient = –0.424). Conclusion: Total serum bilirubin (group 1, an absolute increase in serum creatinine of 0.3 mg/dl or more (equal to an eGFR <80 ml/min)) and hemoglobin (group 2, proteinuria) are useful to predict vivax-induced nephropathy.

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“…175,176 These diseases are listed in Table 28-4, 175-180 and the diagnosis requires renal biopsy. 175,176 These diseases are listed in Table 28-4, 175-180 and the diagnosis requires renal biopsy.…”

Section: Disease-related Changesmentioning

confidence: 99%