Liver and kidney toxicity induced by Afzal smokeless tobacco product in Oman

Al-Mukhaini, Nawal; Ba-Omar, Taher; Eltayeb, Elsadig A.; Al-Shihi, Aisha; Al-Riyami, Nafila; Al-Belushi, Jamila; Al-Adawi, Kawthar

doi:10.1016/j.tice.2017.01.008

Cited by 12 publications

(5 citation statements)

References 18 publications

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“…Nonetheless, our analysis revealed a greater odds ratio of CKD among SLT users. Several experimental studies have proposed a connection between kidney disorders and SLT consumption 36 . Further research in this area is warranted.…”

Section: Discussionmentioning

confidence: 99%

Smokeless tobacco consumption and its association with risk factors of chronic kidney disease in rural and peri-urban Bangladesh

Sarker,

Moriyama,

Sujon

et al. 2023

Tob. Induc. Dis.

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INTRODUCTION Compared to smoking, which has major consequences in chronic kidney disease (CKD) initiation and progression, smokeless tobacco (SLT) consumption is considered to have fewer health consequences. We investigated the prevalence of SLT consumption and its association with risk factors of CKD in a rural and peri-urban Bangladeshi population. METHODS Using random sampling we recruited 872 adults in 2020, from the Mirzapur Demographic Surveillance System of Bangladesh, who had resided in the area for at least five years. Interviews using a semi-structured questionnaire, physical examination and anthropometric measurements were done, followed by blood and urine testing. The blood and urine tests were repeated in selected participants after three months as per the CKD Epidemiology Collaboration equation.

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Section: Discussionmentioning

confidence: 99%

Smokeless tobacco consumption and its association with risk factors of chronic kidney disease in rural and peri-urban Bangladesh

Sarker,

Moriyama,

Sujon

et al. 2023

Tob. Induc. Dis.

View full text Add to dashboard Cite

show abstract

“…When the animal’s liver is damaged, it can lead to impaired energy metabolism and promote the production of creatinine. In addition, the increase of creatinine content is related to renal dysfunction [ 33 ]. A significant increase of creatine in serum was also observed after cinnabar adminstration.…”

Section: Discussionmentioning

confidence: 99%

1H-NMR-Based Metabonomics of the Protective Effect of Coptis chinensis and Berberine on Cinnabar-Induced Hepatotoxicity and Nephrotoxicity in Rats

Wang

Gao

et al. 2017

Molecules

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Coptis chinensis Franch has been used in Traditional Chinese Medicine (TCM) for treating infectious and inflammatory diseases for over two thousand years. Berberine (BN), an isoquinoline alkaloid, is the main component of Coptis chinensis. The pharmacological basis for its therapeutic effects, which include hepatoprotective effects on liver injuries, has been studied intensively, yet the therapy of liver injuries and underlying mechanism remain unclear. We investigated the detoxification mechanism of Coptis chinensis and berberine using metabolomics of urine and serum in the present study. After the treatment with Coptis chinensis and berberine, compared with the cinnabar group, Coptis chinensis and berberine can regulate the concentration of the endogenous metabolites. PLS-DA score plots demonstrated that the urine and serum metabolic profiles in rats of the Coptis chinensis and berberine groups were similar those of the control group, yet remarkably apart from the cinnabar group. The mechanism may be related to the endogenous metabolites including energy metabolism, amino acid metabolism and metabolism of intestinal flora in rats. Meanwhile, liver and kidney histopathology examinations and serum clinical chemistry analysis verified the experimental results of metabonomics.

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“…Moderate and reversible toxicity along with weight loss was found in the esophagus, stomach, liver, kidneys, and lungs [15] . (Presence of ammonia, benzo[a]pyrene, cadmium, nickel, nicotine, nitrates, and tobacco-specific nitrosamines increase the risk of probabilistic cancer [16] . Heavy metals such as arsenic and nickel have synergistic effects with risk factors associated with oral cancer [17] .…”

Section: Introductionmentioning

confidence: 99%

GC-MS Analysis of Smokeless tobacco (Shamma): Toxicological Evaluation

Alzahrani¹,

Alamoudi²,

Aloudah³

et al. 2020

Preprint

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Background: Smoking is a badly addictive habit due to nicotine contents in tobacco. Shammah is one way of smokeless tobacco that is homely made and it use resulting in multiple medical issues. Aim: The aim of the present study were to chemically analyze the content of various types of Shammah using GC-MS analysis with clinical biochemical investigation of some cases usually used shamma in Makkah region, Saudi Arabia. Methods: Three samples from two main different types of shamma (black and yellow) were collected from local providers and analyzed by Gas Chromatography Mass Spectrometry (GC/MS). Eighteen blood samples were also collected from apparently healthy male peoples (30-45 years) classified into 3 groups; group 1 (control) people who doesn't smoke or use any type of shamma, second and third groups were people who usually used black and yellow shamma respectively; CBC and biochemical analysis were performed. Results: In GC-MS Analysis, the nicotine represents the major constituent in all samples. Total RBCs count, Hemoglobin (HGB) Conc., eosinophil % and iron, total cholesterol, HDL-c concentrations were significantly decreased in peoples using either black or yellow shamma whereas serum levels of ALT, AST and ALP enzyme activities, BUN and creatinine levels were significantly increases. Conclusion: Different shamma samples contains different concentrations of various toxic compounds that can produced a serious health problems as hypochromic anemia due to iron deficiency, decrease in eosinophil %, with hepatic and renal cell injuries detected as increase ALT, AST, ALP, BUN, and creatinine levels.

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Liver and kidney toxicity induced by Afzal smokeless tobacco product in Oman

Cited by 12 publications

References 18 publications

Smokeless tobacco consumption and its association with risk factors of chronic kidney disease in rural and peri-urban Bangladesh

Smokeless tobacco consumption and its association with risk factors of chronic kidney disease in rural and peri-urban Bangladesh

1H-NMR-Based Metabonomics of the Protective Effect of Coptis chinensis and Berberine on Cinnabar-Induced Hepatotoxicity and Nephrotoxicity in Rats

GC-MS Analysis of Smokeless tobacco (Shamma): Toxicological Evaluation

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