Liver and kidney ultrasound elastography in children and young adults with hypertension or chronic kidney disease

Močnik, Mirjam; Jančič, Sonja Golob; Varda, Nataša Marčun

doi:10.1007/s00467-023-05984-0

Cited by 5 publications

(9 citation statements)

References 36 publications

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“…UE was also used in children with hypertension or chronic kidney disease to assess its usability in detecting early changes concerning cardiovascular risk evaluation, where in both groups of patients liver stiffness parameters were increased and aggravated by obesity. The latter was also decisive in kidney UE and increased in children with co-existing chronic kidney disease, indicating a possible negative effect of clustering cardiovascular risk factors along with the feasibility of UE to detect the increased stiffness of target organs [ 63 ]. Thus, these studies may possibly provide foundations to detect early cardiovascular risk and early target organ changes; however, further research is needed to confirm that, to develop exam protocols and to determine the grade of stiffness with increased cardiovascular risk.…”

Section: Ultrasound Elastography As An Early Screening Methods Of Car...mentioning

confidence: 99%

“…Children with acute glomerulonephritis had higher mean elastography values than healthy controls [ 61 ]. Similarly, renal cortical stiffness was higher in overweight children [ 62 , 63 ]. On the contrary, children with type 1 diabetes mellitus and normoalbuminuria had similar kidney stiffness values compared to healthy controls [ 56 ].…”

Section: Kidney Ultrasound Elastography In Childrenmentioning

confidence: 99%

“…In children with nephropathy, compared to healthy children, UE seems to be inconsistent due to heterogeneous diseases affecting kidney function, expressing the need for studies with larger sample sizes [ 63 , 66 ]. Regardless of the cause, the progress of chronic kidney disease was associated with higher kidney stiffness in children [ 67 ].…”

Section: Kidney Ultrasound Elastography In Childrenmentioning

confidence: 99%

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Ultrasound Elastography in Children

Močnik

Varda

2023

Children

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Ultrasound elastography is a novel ultrasound technique, being extensively researched in children in the last decade. It measures tissue elasticity with the observation of tissue response after an external stimulus. From research to clinical practice, ultrasound elastography has evolved significantly in liver fibrosis evaluation in children; however, several other applications of the technique are available in both clinical practice and research environments. Practically, in children any organ can be assessed, including the brain in early ages, along with muscle and connective tissue elasticity evaluation, spleen, kidney, skin, lymphatic tissue, etc. The elastography method, age, body mass index and technical points should be considered when performing ultrasound elastography. This review highlights its vast potential as a diagnostic tool in the pediatric population, where ultrasound is a dominant imaging tool; however, the indications and exam protocol for its clinical use in several fields in pediatrics have yet to be elucidated.

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Section: Ultrasound Elastography As An Early Screening Methods Of Car...mentioning

confidence: 99%

Section: Kidney Ultrasound Elastography In Childrenmentioning

confidence: 99%

Section: Kidney Ultrasound Elastography In Childrenmentioning

confidence: 99%

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Ultrasound Elastography in Children

Močnik

Varda

2023

Children

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“…This study is an addition to previously published study about use of liver and kidney elastography in paediatric patients with HTN or CKD, where patients' selection and elastography methods are described in detail [15]. Briefly, patients with CKD or essential HTN were recruited during their admittance for routine follow-up and additional diagnostic procedures.…”

Section: Subjectsmentioning

confidence: 99%

“…Healthy subjects were invited separately. In all participants, liver and kidney UE were performed with already published results [15]. The majority of the participants had body impedance measurement performed during their hospital follow-up.…”

Section: Subjectsmentioning

confidence: 99%

Obesity and Body Composition in Relation to Liver and Kidney Ultrasound Elastography in Paediatric Patients with Either Hypertension or Chronic Kidney Disease

Marčun Varda,

Golob Jančič,

Močnik

2023

Children

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(1) Background: Ultrasound elastography is a novel ultrasound technique for evaluating tissue elasticity. One of the key factors influencing the measurement in children is excess weight. This study aimed to evaluate the effect of body composition, namely, fat mass, on liver and kidney ultrasound elastography in paediatric patients. (2) Methods: 114 participants, in whom bioimpedance, along with liver and kidney ultrasound elastography, were performed, were included (37 patients with chronic kidney disease, 46 patients with hypertension, and 31 healthy subjects). (3) Results: Bioimpedance analysis showed a significant correlation between liver elastography parameters and the phase angle (p = 0.002), fat-free mass (p = 0.001), body cell mass (p = 0.001), total body water (p = 0.001), extracellular water (p = 0.006), and, to lesser extent, fat mass (p = 0.041). On the contrary, kidney elastography parameters strongly correlated only with fat mass (p < 0.001 for both kidneys). (4) Conclusions: Liver and kidney stiffness increased in overweight participants and showed significant correlation with fat mass, particularly in the case of kidney elastography.

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Ultrasound innovations in abdominal radiology: techniques and clinical applications in pediatric imaging

Davis,

Martinez-Correa,

Freeman

et al. 2024

Abdom Radiol

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Contrast-enhanced ultrasound, microvascular imaging, elastography, and fat quantification have varying degrees of utility, with some applications in the pediatric setting mirroring that in adults and having unique uses when applied to children in others. This review will present novel ultrasound technologies and the clinical context in which they are applied to the pediatric abdomen. New ultrasound technologies have a broad range of applications in clinical practice and represent a powerful diagnostic tool with the potential to replace other imaging modalities, such as magnetic resonance imaging and computed tomography, in specific cases.

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Liver and kidney ultrasound elastography in children and young adults with hypertension or chronic kidney disease

Cited by 5 publications

References 36 publications

Ultrasound Elastography in Children

Ultrasound Elastography in Children

Obesity and Body Composition in Relation to Liver and Kidney Ultrasound Elastography in Paediatric Patients with Either Hypertension or Chronic Kidney Disease

Ultrasound innovations in abdominal radiology: techniques and clinical applications in pediatric imaging

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