Liver and Muscle Proteolytic Activity in Male Growing Rats
Fed a Field Bean ( Vicia faba L.) Diet

Santidrian, Santiago; Reyes, E. Favela; Goena, M.; Cuevillas, F; Larralde, J

doi:10.1159/000469252

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Hepatic metabolizm is, first and foremost, a mechanism that converts campounds into products that are easily excreted (Tolman, 1998). It is recorded that liver is target organ in rats given vetch seed (Santidrian et al, 1987;1994). Therefore, the histologic responses of the liver as relavant with fertilizer treatments of vetch seed seem especially important.…”

Section: Introductionmentioning

confidence: 99%

Retraction: The Effect of Raw and Processed Common Vetch Seed (<i>Vicia sativa</i>) Added to Diets of Laying Hens on Performance, Egg Quality, Blood Parameters and Liver Histopathology

et al. 2013

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Abbreviation Key: C＝control diet not containing common vetch seed, CV＝common vetch seed. This study was carried out to determine the effects of raw and physical processed common vetch seed added to diets of laying hens on the laying performance, egg quality traits, blood parameters and liver histopathology. Lohman layers, 46 wk of age as 6 replicate cages each containing 4 hens, were allocated randomly to one of four dietary treatments. Treatment groups were fed diets containing a standard commercial layer diet (Control), basal diet plus 25% raw common vetch seed (CV), 25% autoclaved (at 120℃ for 30 minutes) common vetch seed (ACV) and 25% roasted (at 130℃ for 30 minutes) common vetch seed (RCV) for 12 weeks. Considering the findings of performance traits, differences among the groups were found significant (P＜0,05); however the effects of treatments were not significant on egg quality and blood parameters. The diets containing raw and different physical processed vetchs reduced feed consumption and egg production.CV compared to the control caused lipid accumulation in hepatocytes, severe congestion of hepatic blood vessels, inflammation, the increased numbers of Kupffer cells and sinusoidal dilatations. Findings from present study pointed out the risk of increased hepatic damage due to use of raw vetch seed. It is also remarkable that increasing treatments of vetch seed lead to decrease of liver damages.The results of this experiment indicated that inclusion of CV and ACV in diet affected adversely performance parameters and hepatic damage in laying hens. Alleviation was observed on laying hens fed on diet including 25% RCV.As a conclusion, it has been determined that 25% RCV is more appropriate to use in diets of laying hens than 25% CV and ACV.

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Section: Introductionmentioning

confidence: 99%

Retraction: The Effect of Raw and Processed Common Vetch Seed (<i>Vicia sativa</i>) Added to Diets of Laying Hens on Performance, Egg Quality, Blood Parameters and Liver Histopathology

et al. 2013

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“…The liver plays a crucial role in metabolism (Yokouchi, 2005) and hepatic metabolism is, first and foremost, a mechanism that converts compounds into products that are easily excreted (Tolman, 1998). It is recorded that the liver is the target organ in rats given V. faba (Santidrian et al, 1981;Santidrian et al, 1987;Santidrian et al, 1994). Therefore, the histologic responses of the liver in relation to fertilizer treatments of V. faba is especially important.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Raw and Physical Processed Common Vetch Seed (Vicia sativa) on Laying Performance, Egg Quality, Metabolic Parameters and Liver Histopatology of Laying Hens

Kaya¹,

Çelebi²,

Macit³

et al. 2011

Asian Australas. J. Anim. Sci

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This experiment was designed to evaluate the effects of the processing method of common vetch seed (CVS) (Vicia sativa) on laying performance, egg quality, metabolic parameters and liver histopatology during the peak production period in hens. Lohman layers, 46 wk of age in 6 replicate cages each containing 4 hens, were allocated randomly to one of four dietary treatments. Diets were control (C) diet containing no common vetch and experimental diets containing 25% raw common vetch (RCV), 25% soaked in water for 72 h with exchange of water every 24 h (SCV) and 25% soaked&boiled at 100°C for 30 minute common vetch (SBCV). Inclusion of RCV into the diet deteriorated all laying performance variables. SCV did not alleviate the adverse effect of raw common vetch on feed intake, egg weight, feed conversion, final weight and weight change. SCV partially alleviated egg production (p<0.001). SBCV diminished the adverse effect on feed intake, egg weight, feed conversion, final weight and weight change compared to raw vicia sativa (p<0.001). No significant difference was detected between SBCV and the control group in terms of egg production, feed conversion, final weight and weight change. Regardless of the processing method, all the common vetch groups had lower shell strength compared to the control group. Haugh units did differ between all groups (p<0.001). Inclusion of RCV and SCV into the basal diet decreased triglyceride, cholesterol, total protein and serum glucose concentrations (p<0.001). Hovewer, inclusion of SBCV into the basal diet increased these parameters. Liver samples were stained with Hematoxylin and eosin (HE) and evaluated by light microscopy. A biopsy of native liver tissue was used as a control. No histopathologic finding was present in the control group. Raw V. sativa compared with the control caused lipid accumulations in hepatocytes, severe congestion of hepatic blood vessels, inflammation, increased numbers of Kupffer cells and sinusoidal dilatations. Whereas, the livers from groups given treated V. sativa showed only different degrees of sinusoidal dilatations. Findings from the present study point out the risk of increased hepatic damage due to use of raw Vicia sativa. Increasing treatment of V. sativa lead to a decrease of liver damages. Inclusion of raw and soaked vetch seeds in rations affected adversely all parameters examined in laying hens. But alleviation was observed when soaked and boiled vetch seeds (SBCV) were fed. The results of these experiments indicated that soaked&boiled Vicia sativa seeds may safely be used at a 25% level in rations of laying hens.

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Stabilization of porcine spleen cathepsin A with chaotropic ions and its destabilization with thiols at intralysosomal pH

Ikeda

Kazuhiko

Suzuki

1992

International Journal of Biochemistry

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Liver and Muscle Proteolytic Activity in Male Growing Rats Fed a Field Bean ( Vicia faba L.) Diet

Cited by 4 publications

References 15 publications

Retraction: The Effect of Raw and Processed Common Vetch Seed (<i>Vicia sativa</i>) Added to Diets of Laying Hens on Performance, Egg Quality, Blood Parameters and Liver Histopathology

Retraction: The Effect of Raw and Processed Common Vetch Seed (<i>Vicia sativa</i>) Added to Diets of Laying Hens on Performance, Egg Quality, Blood Parameters and Liver Histopathology

The Effects of Raw and Physical Processed Common Vetch Seed (Vicia sativa) on Laying Performance, Egg Quality, Metabolic Parameters and Liver Histopatology of Laying Hens

Stabilization of porcine spleen cathepsin A with chaotropic ions and its destabilization with thiols at intralysosomal pH

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