Liver and peripheral blood mononuclear cells are not major sites for GB virus-C/hepatitis G virus replication

Kao, Jia‐Horng; Chen, W.; Chen, P.-J.; Lai, Ming‐Yang; Chen, D.-S.

doi:10.1007/s007050050631

Cited by 12 publications

(7 citation statements)

References 31 publications

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“…The potential of HGV to cause hepatitis in humans is questionable. Controversial data exist concerning whether or not HGV replicates in the liver [3][4][5][6] . HGV is highly prevalent among population groups at risk of parenterally transmitted viral agents, but it has also a worldwide distribution in other non-risk population groups.…”

mentioning

confidence: 99%

Prevalence and Genotypes of Hepatitis G Virus among Hemodialysis Patients in Eastern Anatolia, Turkey

Özdarendeli

Toroman²,

Kalkan³

et al. 2005

Med Princ Pract

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Objectives: To study the prevalence and genotype distribution of hepatitis G virus (HGV) in hemodialysis patients in East Anatolia, Turkey. Subjects and Materials: Eighty-nine hemodialysis patients and 30 healthy individuals were analyzed by using reverse-transcriptase nested polymerase chain reaction with primers specific for 5′ untranslated region. HGV genotyping was performed by PCR and three randomly selected HGV-positive samples were sequenced. Results: Of the 89 hemodialysis patients, HGV RNA was detected in 9 (10.2%). All of our isolates were assigned to genotype 2. Conclusion: Our results showed that hemodialysis patients carry the risk for HGV infection in East Anatolia, Turkey.

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mentioning

confidence: 99%

Prevalence and Genotypes of Hepatitis G Virus among Hemodialysis Patients in Eastern Anatolia, Turkey

Özdarendeli

Toroman²,

Kalkan³

et al. 2005

Med Princ Pract

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“…Recent data suggest that GBV-C:HGV may replicate in human peripheral blood mononuclear cells (PBMC) (70,71) and in endothelial cells (72). The ndings have, however, been questioned (73). So far knowledge of the tissuespeci c tropism and the major site of replication for GBV-C:HGV are limited.…”

Section: Tissue Tropismmentioning

confidence: 99%

GB Virus C/Hepatitis G Virus

Halasz

Weiland²,

Sällberg³

2001

Scandinavian Journal of Infectious Diseases

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GB virus C (GBV-C), or hepatitis G virus (HGV), is a recently discovered enveloped RNA virus belonging to the Flaviviridae family. GBV-C/HGV is transmitted by contaminated blood and/or blood products, intravenous drug use, from mother to child, sexually, and possibly through close social contacts. Several reports indicate a high prevalence of GBV-C/HGV viremia (1-4%) within healthy populations in Europe and North America, and an even higher prevalence (10-33%) among residents in South America and Africa. GBV-C/HGV has been suggested to be a causative agent for non-A-non-E hepatitis. However, several contradictory observations suggest that its ability to cause hepatitis is questionable. Taken together most data suggest that GBV-C/HGV is not a major cause of liver disease despite recent data indicating that it may infect and replicate in hepatocytes.

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“…Although GBV-C was suggested initially to be a hepatitis virus, subsequent studies indicated that majority of GBV-C-infected patients had no detectable evidence of hepatitis [Stapleton, 2003]. Furthermore, lines of evidence argued that GBV-C might not be a hepatotropic virus [Laskus et al, 1998;Kao et al, 1999]. On the other hand, TTV and SEN virus are both believed to be hepatotropic viruses.…”

Section: Introductionmentioning

confidence: 96%

Identification of NV‐F virus DNA in hepatocellular carcinoma

Yeh

Chen

Chang

et al. 2006

Journal of Medical Virology

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A fragment of DNA sequence derived from a hepatotropic virus, named NV-F was isolated recently. The aim of this study was to examine whether this virus was associated with hepatocellular carcinoma (HCC). Total cellular DNA was extracted from hepatocellular carcinoma tissues. NV-F virus DNA was detected by PCR. The PCR products were subjected to sequence analysis. Of the 78 HCC samples included, 12 (15.4%) were positive for NV-F virus DNA. Sequence analysis of the 12 amplified DNA fragments revealed a point mutation in one of them. The clinicopathological parameters between patients with and without NV-F virus infection were compared. It was found that patients with NV-F virus infection were older than those without NV-F virus infection (mean ages, 61.5 versus 52.5 years; P = 0.032). Otherwise, no difference was observed between the two groups. Of the 12 HCC patients positive for NV-F virus DNA, 11 patients were co-infected by either hepatitis B or C virus. The remaining patient was a Taiwanese aboriginal inhabitant with cryptogenic cirrhosis. In conclusion, NV-F virus DNA was identified in 15.4% of HCC tissues. HCC patients with NV-F virus infection were significantly older than those without NV-F virus infection.

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Liver and peripheral blood mononuclear cells are not major sites for GB virus-C/hepatitis G virus replication

Cited by 12 publications

References 31 publications

Prevalence and Genotypes of Hepatitis G Virus among Hemodialysis Patients in Eastern Anatolia, Turkey

Prevalence and Genotypes of Hepatitis G Virus among Hemodialysis Patients in Eastern Anatolia, Turkey

GB Virus C/Hepatitis G Virus

Identification of NV‐F virus DNA in hepatocellular carcinoma

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