Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report

Millán, Mauricio; Delgado, Alejandro; Caicedo, Luis A.; Arrunategui, Ana María; Meneses, Carlos A.; Villegas, Jorge I.; Serrano, Oscar; Caicedo, Liliana; Duque, Mauricio; Echeverri, Gabriel J.

doi:10.1016/j.ijscr.2016.09.044

Cited by 12 publications

(13 citation statements)

References 12 publications

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“…On MRI, the tumors appear as a heterogeneous area, and hemorrhage is reflected by hyperintense spots or patchy signals on T1 and T2-weighted images. PET/CT scan has a major role in staging the tumor and detection of distant metastasis, appearing FDG-avid on PET-CT [ [17] , [18] , [19] ]. Cinematic rendering is a recently described 3-dimensional (3D) imaging technique that generates photorealistic images based on a new lighting model [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatic angiosarcoma in an adult who had Wilms tumor treated in childhood: A case report

Shayesteh

Fouladi

Blanco

et al. 2021

Radiology Case Reports

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Hepatic angiosarcoma is a rare, highly aggressive mesenchymal liver malignancy with poor prognosis that stems from the endothelial cells that line the walls of blood or lymphatic vessels. It is the third most common primary liver malignancy and is most prevalent among older males. It is difficult to diagnose due to various clinical presentations from asymptomatic to abdominal pain, pleural effusion, and liver failure. The diagnosis of liver angiosarcoma is suspected on imaging features and confirmed by histopathological assessment. Primary management is determined based on the stage of tumor from surgery to palliative care such as chemotherapy or tumor transarterial embolization. We report a 51-year-old female who presented with stage 4 liver angiosarcoma and a history of childhood Wilms tumor. We focus on tumor management using radiological modalities and pathological analysis and discuss secondary liver tumors in survivors of childhood Wilms tumor.

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Section: Discussionmentioning

confidence: 99%

Hepatic angiosarcoma in an adult who had Wilms tumor treated in childhood: A case report

Shayesteh

Fouladi

Blanco

et al. 2021

Radiology Case Reports

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“…While up to 75% of cases are of unknown aetiology, known risk factors for the development of hepatic angiosarcoma include the use of oral contraceptives, exposure to anabolic steroids, radiation, thorium dioxide, arsenic and vinyl chloride 4. There is also a link between the development of hepatic angiosarcoma in patients with neurofibromatosis type 1 and haemochromatosis 10.…”

Section: Discussionmentioning

confidence: 99%

“…Optimal management of patients is poorly demarcated due to the rarity of hepatic angiosarcoma 18. Most patients pass away within 2 years of diagnosis and have a median survival time of 6 months without treatment 4. Liver transplantation is contraindicated in patients with hepatic angiosarcoma due to a high recurrence rates and poor survival outcomes despite transplantation.…”

Section: Discussionmentioning

confidence: 99%

Hepatic angiosarcoma as a cause of acute liver failure

Singh¹,

Mills

Asadi

et al. 2018

BMJ Case Reports

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Hepatic angiosarcoma is an extremely rare disease entity that accounts for approximately 0.1%-2% of primary liver malignancy. It is three times more common in men than women and usually affects the former in their sixth or seventh decade of life. Risk factors for the development of hepatic angiosarcoma include the use of oral contraceptives, exposure to anabolic steroids, radiation, thorium dioxide, arsenic and vinyl chloride. The prognosis of hepatic angiosarcoma is extremely poor which is attributable to early metastases to other organs, resistance to traditional chemotherapy and radiotherapy regimens and rapid progression of the tumour. Optimal management of patients is poorly demarcated due to the rarity of the tumour. We present a case series of two patients: one who passed away due to acute hepatic failure secondary to hepatic angiosarcoma and the second who underwent a liver transplantation and was subsequently diagnosed with hepatic angiosarcoma based on his explant histology.

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“…Unfortunately, only few studies have reported on the association of HAS with fatty liver. Millan et al [ 14 ] reported a case of HAS with a 7-year history of fatty liver. HAS with nonalcoholic steatohepatitis was also reported in Japan (unpubl.…”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Angiosarcoma: A Case Report with 10-Year Patient Medical Data

Ogawa

Sasahara

2017

Case Rep Oncol

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In the current study, we report a case of a 46-year-old man who presented with sudden abdominal pain and was diagnosed with rupture of hepatic angiosarcoma (HAS). He underwent surgery, but died 13 days after the onset of the abdominal pain. Chronic exposure to carcinogens, such as thorium dioxide, arsenic, vinyl chloride, and radium, is associated with HAS. However, our patient had not been exposed to such carcinogens. He had submitted himself for annual medical checkups since he was employed. His liver was cirrhotic, and medical history data showed that he had had fatty liver for at least 10 years before HAS onset. Although liver cirrhosis may play a role in the occurrence of HAS, the connection of chronic fatty liver in the tumorigenesis remains unclear. Case reports regarding HAS with fatty liver are few. To the best of our knowledge, this is the first case of HAS occurring in a cirrhotic liver that advanced from persistent fatty stage. Given that HAS is a rare tumor, data collection is important for investigating its pathophysiology. Case presentations considering health conditions before HAS onset are limited; therefore, we present a case of HAS with annual health checkup data before disease onset.

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Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report

Abstract: HighlightsLiver Angiosarcoma is rare and aggressive tumour that requires surgical management.Partial Hepatectomy is the ideal surgical management for Liver Angiosarcoma.Liver transplant does not improve the survival of Liver Angiosarcoma patients.

Cited by 12 publications

References 12 publications

Hepatic angiosarcoma in an adult who had Wilms tumor treated in childhood: A case report

Hepatic angiosarcoma in an adult who had Wilms tumor treated in childhood: A case report

Hepatic angiosarcoma as a cause of acute liver failure

Primary Hepatic Angiosarcoma: A Case Report with 10-Year Patient Medical Data

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