Liver apparent diffusion coefficient repeatability with individually predetermined optimal cardiac timing and artifact elimination by signal filtering

Metens, Thierry; Absil, Julie; Denolin, Vincent; Bali, Maria Antonietta; Matos, Celso

doi:10.1002/jmri.25089

Cited by 27 publications

(27 citation statements)

References 21 publications

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“…Some solutions to reduce the effects of cardiac motion have been proposed. These include the postprocessing method[24] or filtering[27] which corrects the image after signal acquisition or cardiac triggering synchronized with the heart cycle[27,28]. ADC reproducibility was reportedly improved using these methods.…”

Section: Fundamentals and Techniquesmentioning

confidence: 99%

Diffusion-weighted imaging of the liver: Current applications

Saito

Tajima

Harada

2016

WJR

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Diffusion-weighted imaging (DWI) of the liver can be performed using most commercially available machines and is currently accepted in routine sequence. This sequence has some potential as an imaging biomarker for fibrosis, tumor detection/characterization, and following/predicting therapy. To improve reliability including accuracy and reproducibility, researchers have validated this new technique in terms of image acquisition, data sampling, and analysis. The added value of DWI in contrast-enhanced magnetic resonance imaging was established in the detection of malignant liver lesions. However, some limitations remain in terms of lesion characterization and fibrosis detection. Furthermore, the methodologies of image acquisition and data analysis have been inconsistent. Therefore, researchers should make every effort to not only improve accuracy and reproducibility but also standardize imaging parameters.

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Section: Fundamentals and Techniquesmentioning

confidence: 99%

Diffusion-weighted imaging of the liver: Current applications

Saito

Tajima

Harada

2016

WJR

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“…The minimum displacement trigger delay found with this approach matched the delay for which the DWI images were less affected by the cardiac‐related signal loss. This method is actually less subjective than a visual assessment of the left liver lobe displacement as suggested before, that moreover could not be used for the right liver or the pancreas. In contrast, the new method is applicable to any region of the liver and probably to other organs as well.…”

Section: Discussionmentioning

confidence: 99%

“…This delay was compared with a trigger time computed from the motion velocity field that corresponded to the minimum displacement. Our hypothesis was to consider the latter to be the best candidate for optimal diffusion‐weighted cardiac triggering . From the motion velocity field, the time interval with minimum movement was also computed.…”

Section: Methodsmentioning

confidence: 99%

“…Several studies have shown that an appropriate cardiac triggering does improve both the quality of DWI images and diffusion quantitative measurements in the left and the right lobes of the liver . However, the determination of the optimum cardiac triggering remains time consuming with repeated DWI at different trigger delays or rather subjective when using the visual assessment of the left liver as shown previously .…”

Section: Introductionmentioning

confidence: 96%

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Assessment of cardiac‐driven liver movements with filtered harmonic phase image representation, optical flow quantification, and motion amplification

Hahn

Absil

Debeir

et al. 2018

Magnetic Resonance in Med

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Purpose To characterize cardiac‐driven liver movements using a harmonic phase image representation (HARP) with an optical flow quantification and motion amplification method. The method was applied to define the cardiac trigger delay providing minimal signal losses in liver DWI images. Methods The 16‐s breath‐hold balanced‐SSFP time resolved 20 images/s were acquired at 3T in coronal and sagittal orientations. A peripheral pulse unit signal was recorded. Cardiac‐triggered DWI images were acquired after different peripheral pulse unit delays. A steerable pyramid decomposition with multiple orientations and spatial frequencies was applied. The liver motion field‐map was derived from temporal variations of the HARP representation filtered around the cardiac frequency. Liver displacements were quantified with an optical flow method; moreover the right liver motion was amplified. Results The largest displacements were observed in the left liver (feet‐head:3.70 ± 1.06 mm; anterior–posterior: 2.35 ± 0.51 mm). Displacements were statistically significantly weaker in the middle right liver (0.47 ± 0.11 mm; P = 0.0156). The average error was 0.013 ± 0.022 mm (coronal plane) and 0.021 ± 0.041 mm (sagittal plane). The velocity field demonstrated opposing movements of the right liver extremities during the cardiac cycle. DWI signal loss was minimized in regions and instants of smallest amplitude of both velocity and velocity gradient. Conclusion Cardiac‐driven liver movements were quantified with combined cardiac frequency‐filtered HARP and optical flow methods. A motion phase opposition between right liver extremities was demonstrated. Displacement amplitude and velocity were larger in the left liver especially along the vertical direction. Motion amplification visually emphasized cardiac‐driven right liver displacements. The optimal cardiac timing minimizing signal loss in liver DWI images was derived.

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“…20,21 Cardiac triggering is not often used but may have value in DW-MRI in the upper abdomen. 22 Peristaltic motion can be reduced by administration of an anti-peristaltic agent before imaging.…”

Section: Technical Challenges In Data Acquisitionmentioning

confidence: 99%

DCE-MRI, DW-MRI, and MRS in Cancer

Winfield

Payne

Weller

et al. 2016

Topics in Magnetic Resonance Imaging

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Multi-parametric magnetic resonance imaging (mpMRI) offers a unique insight into tumor biology by combining functional MRI techniques that inform on cellularity (diffusion-weighted MRI), vascular properties (dynamic contrast-enhanced MRI), and metabolites (magnetic resonance spectroscopy) and has scope to provide valuable information for prognostication and response assessment. Challenges in the application of mpMRI in the clinic include the technical considerations in acquiring good quality functional MRI data, development of robust techniques for analysis, and clinical interpretation of the results. This article summarizes the technical challenges in acquisition and analysis of multi-parametric MRI data before reviewing the key applications of multi-parametric MRI in clinical research and practice.

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Liver apparent diffusion coefficient repeatability with individually predetermined optimal cardiac timing and artifact elimination by signal filtering

Abstract: Compared to noncardiac-triggered acquisitions, individually optimized cardiac-triggered acquisitions improved ADC repeatability in both liver lobes and reduced ADC differences between left and right liver. Left liver ADC repeatability was further improved after signal filtering.

Cited by 27 publications

References 21 publications

Diffusion-weighted imaging of the liver: Current applications

Diffusion-weighted imaging of the liver: Current applications

Assessment of cardiac‐driven liver movements with filtered harmonic phase image representation, optical flow quantification, and motion amplification

DCE-MRI, DW-MRI, and MRS in Cancer

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