Liver biopsy in gall stone disease: a prospective study in patients undergoing cholecystectomy

Abstract

Background: Cholelithiasis has affected mankind since many centuries. It not only affects the biliary tree but also has adverse effects on the hepatic parenchyma, which can get further complicated due to infected bile. Early intervention in these cases not only retards the unwanted effects but also prevents irreversible damage to liver. Aim of study was to see the effect of gallstone disease on liver in patients of GSD (Cholelithiasis, Chronic cholecystitis, CBD Stones).Methods: All patients being subjected for planned cholecystectomy were taken as subjects irrespective of age, sex and co-morbid conditions.Results: 90 patients were included in study and they were evaluated for secondary histopathological changes in liver. Abnormal liver histology was seen in 40% of the cases, with portal tract inflammation being the commonest abnormality seen in 24.4% of patients followed by fatty change (17.8%), cholestasis (10%), lobular parenchymal infiltration (8.9%) and one (1.1%) patient had fibrosis. Choledocholithiasis was associated with a greater incidence of positive bile culture (60%) and greater incidence of abnormal liver histology (80%).Conclusions: Gall stone disease cause significant changes in liver histology and these changes are more common in those patients having long duration of symptoms. In patients of choledocholithiasis incidence of infected bile and liver histology changes are more as compared to cholelithiasis with chronic cholecystitis.

Gallstone-Associated Histopathological Changes in Liver: A Prospective Observational Study

“…Liver histology changes were present in six patients (75%), and all six patients had portal tract infiltration and cholestasis, and bile culture was positive in five patients. This observation aligns with the study findings of Patel G. et al [ 3 ]. Consequently, the present study suggests a positive correlation between symptom duration and liver histological changes, indicating that longer durations of symptoms increase the likelihood of significant changes in liver biopsy.…”

“…Similarly, in this study, the mean age of the patients was 39.28 ± 13.73 years, and most patients were female. These findings are similar to the previous reports [ 3 , 4 , 16 , 17 ].…”

“…Patients with gallstone disease may develop cholangitis, a condition that, over time, can lead to secondary hepatic changes such as fatty liver, fibrosis, secondary biliary cirrhosis, reactive hepatitis, and nonspecific inflammatory alterations. Notably, individuals with choledocholithiasis experience more extensive liver damage compared to those with cholecystitis and cholelithiasis [ 3 ].…”

Effect of transient obstructive cholestasis on liver histology: a cross-sectional study

“…Moreover, Patel et al also observed histopathological cholestasis in 10% of their patients who underwent uncomplicated cholecystolithiasis cholecystectomy. 9 , 10 The possibility of occurrences of resolved subclinical cholestatic events or undetected biliary diseases of undetermined clinical importance was raised in these previous studies, and this is reinforced by the findings of the current study.…”