Liver Biopsy in Patients With Alcohol-Associated Liver Disease With Acute-on-Chronic Liver Failure

Abstract

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Preoperative risk evaluation and optimization for patients with liver disease

“…This may be relevant when trying to differentiate biliary obstruction from hepatic dysfunction. However, liver biopsy is less effective for predicting mortality than non-invasive scoring systems such as MELD and Maddrey’s Discriminant Function (DF) [ 39 ]. Several prognostic scoring systems have been validated for use in AH.…”

Alcohol use disorder and liver injury related to the COVID-19 pandemic

“…Some studies have claimed that patients with ACLF of alcoholic etiology have significantly prolonged hospital stay, severe COVID-19, admission to the intensive care unit and higher mortality[ 37 , 38 ], while others have shown that ACLF is often triggered not only by ongoing alcohol consumption, but also gastrointestinal bleeding and/or infections, and from a pathophysiological point of view it is characterized by uncontrolled systemic inflammation coupled with paradoxical immunoparesis. ACLF has a clear pathogenesis and epidemiological burden and is different from decompensated cirrhosis; it represents a challenging condition with a rapid clinical course, high short-term mortality and varying clinical phenotypes[ 39 , 40 ].…”