Liver cancer in <scp>M</scp>alaysia: Epidemiology and clinical presentation in a multiracial <scp>A</scp>sian population

Goh, Khean Lee; Razlan, Hamizah; Hartono, Juanda Leo; Qua, Choon‐Seng; Yoong, Boon Koon; Koh, Peng Soon; Abdullah, Basri Johan Jeet

doi:10.1111/1751-2980.12223

Cited by 26 publications

(21 citation statements)

References 12 publications

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“…The highest estimated difference in the rate of CRC was observed in Australia/New Zealand (44.8 and 32.2 per 100,000 in males and females, respectively), and a similar difference was observed in Western Africa (4.5 and 3.8 per 100,000 in males and females, respectively) [1]. In Malaysia, the same trend was observed in hepatocellular cancer, which is the second most common cancer after CRC in Malaysia and is 3.40 times likely to occur in males than females [5,13]. The reason why females exhibit a lower risk for CRC is unclear, but several studies have suggested that females hormones may have a protective effect against CRC by way of changes in bile synthesis and secretion that lead to a reduced concentration of bile acids in the colon [14,15].…”

Section: Discussionmentioning

confidence: 56%

Incidence and mortality rates of colorectal cancer in Malaysia

et al. 2016

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OBJECTIVESThis is the first study that estimates the incidence and mortality rate for colorectal cancer (CRC) patients in Malaysia by sex and ethnicity.METHODSThe 4,501 patients were selected from National Cancer Patient Registry-Colorectal Cancer data. Patient survival status was cross-checked with the National Registration Department. The age-standardised rate (ASR) was calculated as the proportion of CRC cases (incidence) and deaths (mortality) from 2008 to 2013, weighted by the age structure of the population, as determined by the Department of Statistics Malaysia and the World Health Organization world standard population distribution.RESULTSThe overall incidence rate for CRC was 21.32 cases per 100,000. Those of Chinese ethnicity had the highest CRC incidence (27.35), followed by the Malay (18.95), and Indian (17.55) ethnicities. The ASR incidence rate of CRC was 1.33 times higher among males than females (24.16 and 18.14 per 100,000, respectively). The 2011 (44.7%) CRC deaths were recorded. The overall ASR of mortality was 9.79 cases, with 11.85 among the Chinese, followed by 9.56 among the Malays and 7.08 among the Indians. The ASR of mortality was 1.42 times higher among males (11.46) than females (8.05).CONCLUSIONSCRC incidence and mortality is higher in males than females. Individuals of Chinese ethnicity have the highest incidence of CRC, followed by the Malay and Indian ethnicities. The same trends were observed for the age-standardised mortality rate.

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Section: Discussionmentioning

confidence: 56%

Incidence and mortality rates of colorectal cancer in Malaysia

et al. 2016

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“…Up to 30% of HCC can be attributable to cryptogenic cirrhosis; the majority of such cases are believed to be due to NASH . Cross‐sectional studies in Asian countries such as Malaysia, Japan, and Korea suggest that the contribution of NASH to HCC is lower than in the West and is in the region of 7–16% …”

Section: Epidemiologymentioning

confidence: 99%

Asia–Pacific Working Party on Non‐alcoholic Fatty Liver Disease guidelines 2017—Part 1: Definition, risk factors and assessment

Wong

Chan

Chitturi

et al. 2017

J of Gastro and Hepatol

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430

442

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“…Advanced stages are characterized by the presence of extra hepatic spread, vascular invasion, and the presence of cancer-related symptoms. 17 In this study, the majority of HCC patients were also positively infected with the hepatitis B virus. The hepatitis B is the most dominant risk factor for HCC cases.…”

Section: Discussionmentioning

confidence: 70%

Expression of circulating miR-200c and vascular endothelial growth factor-A (VEGF-A) mRNA as potential biomarker in human hepatocellular carcinoma

et al. 2018

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Hepatocellular carcinoma (HCC) is a common liver disease that causes significant public health problems throughout the world, including in Indonesia. The HCC is the six most common cancers and second cancer-related deaths among men in the world. Recently it was reported that the microRNA is an important player in hepatocarcinogenesis. The expression of MiRNA-200c is often regulated in primary HCC and HCC cell lines. Vascular endothelial growth factor-A (VEGF-A) is a regulator of angiogenesis that has been reported as miR-200c target gene. This study was conducted to measure expression levels in miR-200c and mRNAVEGF-A and their potential role as biomarkers at HCC. A total of 36 HCC patients and 36 healthy subjects were included in this study. The relative expression of miRNA-200c and mRNA VEGF-A was quantified using reverse transcription real time quantitative PCR (qRT PCR). Relative expression was calculated using. Unpaired t-test was used to compare the expression levels of circulating miRNA-200c and mRNA VEGF-A in HCC patients and healthy subjects. Pearson test was used to determine correlation between circulating miR-200c expression and mRNA VEGF-A expression levels. The expression levels of circulating miR-200c in HCC patients were lower compared to healthy subjects although it was not significant (p = 0.258). Conversely, the expression levels of circulating mRNA VEGF-A in HCC patients were significantly higher compared to healthy subjects (p = 0.001). The relative expression levels of circulating miR-200c were negatively correlated with mRNA VEGF-A in HCC patients. In conclusion, the expression levels of mRNA VEGF-A in HCC patients are significantly deregulated in compared to that in healthy subjects. Negative correlation between circulating miRN-200c and mRNA VEGF-A expression levels are reported in HCC patients. ABSTRAK Hepatocellular carcinoma (HCC) adalah penyakit hati yang umum dan menyebabkan masalah kesehatan masyarakat yang signifikan di seluruh dunia, termasuk di Indonesia. Karsinoma hepatoseluler adalah penyebab kematian keenam akibat kanker umumnya dan kedua pada laki-laki di seluruh dunia. Saat ini microRNA dilaporkan berperan penting dalam hepatokarsinogenesis. Ekspresi MiRNA-200c mengalami deregulasi pada jaringan HCC primer dan sel HVCC. Vascular endothelial growth factor-A (VEGF-A) adalah regulator angiogenesis yang dilaporkan sebagai gen target miR-200c. Penelitian ini dilakukan untuk mengkaji ekspresi miR-200c dan mRNA VEGF-A serta peran

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Liver cancer in Malaysia: Epidemiology and clinical presentation in a multiracial Asian population

Abstract: HCC is most common among Chinese, followed by Malays and Indians in Malaysia. The etiology of HCC shows a peculiar racial pattern.

Cited by 26 publications

References 12 publications

Incidence and mortality rates of colorectal cancer in Malaysia

Incidence and mortality rates of colorectal cancer in Malaysia

Asia–Pacific Working Party on Non‐alcoholic Fatty Liver Disease guidelines 2017—Part 1: Definition, risk factors and assessment

Expression of circulating miR-200c and vascular endothelial growth factor-A (VEGF-A) mRNA as potential biomarker in human hepatocellular carcinoma

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