1984
DOI: 10.1002/1097-0142(19840715)54:2<315::aid-cncr2820540223>3.0.co;2-6
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Liver cell dysplasia and hepatitis B surface antigen in liver cirrhosis and hepatocellular carcinoma

Abstract: Liver tissues of 223 autopsy cases of cirrhosis and hepatocellular carcinoma were examined for liver cell dysplasia in relation to hepatitis B surface antigen (HBsAg) detected with orcein stain. Liver cell dysplasia was found in 94 cases (42.2%): 37 were from cases of cirrhosis only, and 53 were from cases of cirrhosis with hepatocellular carcinoma. There was a significant difference in the overall incidence of HBsAg in cases with and without dysplasia (70.2%:32.6%). A similar difference was found in all group… Show more

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Cited by 36 publications
(9 citation statements)
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“…Its pre-neoplastic significance has been inferred in several reports because of its frequent association with hepatocellular carcinoma (HCC) and/or chronic hepatitis B virus infection (Bartok et al, 1981;Ho et al, 1981;Akagi et al, 1984;Roncalli et al, 1985Roncalli et al, , 1986. We have observed some morphometric similarities between LCD and HCC (Roncalli et al, 1988).…”
supporting
confidence: 60%
“…Its pre-neoplastic significance has been inferred in several reports because of its frequent association with hepatocellular carcinoma (HCC) and/or chronic hepatitis B virus infection (Bartok et al, 1981;Ho et al, 1981;Akagi et al, 1984;Roncalli et al, 1985Roncalli et al, , 1986. We have observed some morphometric similarities between LCD and HCC (Roncalli et al, 1988).…”
supporting
confidence: 60%
“…Liver cell dysplasia has long been considered a preneoplastic condition. 18,19 A prospective study of cirrhotic patients with or without liver cell dysplasia showed a significantly higher rate of development of HCC in those with dysplasia. 20 The overexpression of the exon 5-deleted form in dysplastic liver tissue (evaluated by comparing the two amplified fragments in the linear phase of the PCR reaction) constitutes a strong resemblance with HCC 12 : continued stimulation of estrogenregulated growth function, regardless of the estrogenic status of the environment, might favor inappropriate proliferation facilitating the progression of cirrhosis toward HCC.…”
Section: Discussionmentioning
confidence: 99%
“…Gel Electrophoresis and Hybridization. Fifty microliters from 100 µL of PCR products was precipitated on ice by adding 2 volumes of 100% ethyl alcohol, resuspended, applied on 1.8% agarose alkaline gel, 19 electrophoresed, and transferred overnight to nylon membranes (Hybond N, Bio Rad Laboratories, Hercules, CA). After drying and UV fixation, the membranes were prehybridized in a mixture containing 50% formamide, 5ϫ saline sodium citrate (SSC; 0.75 mol/L NaCl, 0.075 mol/L sodium citrate), 5ϫ Denhardt' s, 0.1% Ficoll (type 400; Pharmacia, Cologno Monzese, Italy), 0.1% polyvinylpyrrolidone, 0.1% bovine serum albumin (fraction V; Sigma), and 50 mmol/L NaHPO 4 (pH 7.0) at 42°C for at least 2 hours.…”
Section: Methodsmentioning
confidence: 99%
“…7 8 The frequent association of such dysplastic foci with HCC arising in cirrhotic livers suggests a preneoplastic role for liver cell dysplasia in the sequence driving cirrhosis towards HCC. [9][10][11] Although two large prospective studies have suggested that LCC is the most important risk factor for HCC, 12 13 its premalignant nature is still controversial. [13][14][15][16] To date, there are no genetic reports supporting a direct transition from liver cell dysplasia to HCC.…”
mentioning
confidence: 99%