Liver Contrast-Enhanced Ultrasound Improves Detection of Liver Metastases in Patients with Pancreatic or Periampullary Cancer

Taimr, Pavel; Jongerius, Vivian L.; Pek, Chulja J.; Krak, Nanda C.; Hansen, Bettina E.; Janssen, Harry L.A.; Metselaar, Herold J.; Eijck, Casper H.J. van

doi:10.1016/j.ultrasmedbio.2015.06.019

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…CEUS can accurately detect the location and invasion range of periampullary malignant lesions, including duodenal, vascular invasion, and intrahepatic metastasis [29]. CEUS can also be used to identify non-neoplastic obstructive lesions without enhancement, especially when the tumor coexists with biliary mud, which is of great clinical value [15, 30]. Compared with MRI, CEUS is a more cost-effective strategy that is convenient for the bedside.…”

Section: Discussionmentioning

confidence: 99%

“…CEUS functions by assessing microbubble-enhanced blood flow and distribution. The primary advantages of CEUS include its high temporal resolution, lack of ionizing radiation, and real-time imaging capabilities [15]. However, CEUS is not preferred for imaging of PAC as its specificity and accuracy are inferior to MRI [6, 15].…”

Section: Introductionmentioning

confidence: 99%

“…The primary advantages of CEUS include its high temporal resolution, lack of ionizing radiation, and real-time imaging capabilities [15]. However, CEUS is not preferred for imaging of PAC as its specificity and accuracy are inferior to MRI [6, 15]. Moreover, CEUS has some limitations, including its dependence on the operator experience and inability to visualize tissues at depths greater than 3 cm [16].…”

Section: Introductionmentioning

confidence: 99%

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Combination of CEUS and MRI for the diagnosis of periampullary space-occupying lesions: a retrospective analysis

et al. 2019

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Background The value of magnetic resonance imaging (MRI), contrast-enhanced ultrasound (CEUS), and the combination of CEUS and MRI (CCWM) for the diagnosis of periampullary space-occupying lesions (PSOL) was investigated. Methods A total of 102 patients diagnosed with PSOLs by surgery or biopsy were recruited retrospectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MRI, CEUS, and CCWM were analyzed. Results MRI, CEUS, and CCWM allowed for the accurate detection of 91.17, 92.15, and 99.01% of PSOLs, respectively. The specificity, PPV, and accuracy of CCWM were significantly different from MRI and CEUS ( p < 0.05). However, there the sensitivity and NPV were not significantly different among the three diagnostic technologies. In addition, the specificity, PPV, and accuracy were not significantly different between MRI and CEUS (all p > 0.05). Conclusions CCWM is valuable for differentiating benign and malignant PSOL, which provides important guiding significances for the clinic.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combination of CEUS and MRI for the diagnosis of periampullary space-occupying lesions: a retrospective analysis

et al. 2019

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“…Therefore, it is crucial to have accurate preoperative methods for the detection of liver metastases [29]. Despite advances in modern imaging techniques, assessing the presence of liver metastases remains challenging; currently there is no reliable method for detecting small, occult liver metastases [30, 31].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Focal Liver Lesions Indistinctive on B Mode Ultrasound: Benefits of Contrast-Enhanced Ultrasound

Mao²,

Cao

et al. 2017

BioMed Research International

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Aim. The aim of this prospective study was to evaluate the additional value of contrast-enhanced ultrasound (CEUS) in identifying and characterizing of focal liver lesions (FLLs) that are indistinctive on B mode ultrasound (BMUS). Methods. The study focused on 70 consecutive patients (male 46, female 24; mean age, 53.1 years ± 10). All lesions were detected by MRI but could not be clearly visualized by BMUS. CEUS was performed by injected SonoVue® (Bracco Imaging Spa, Milan, Italy) as a quick bolus into the antecubital vein. All lesions were proved by pathologic and MRI findings as primary or metastatic hepatic malignancies. Results. On CEUS, 45 (64.2%) FLLs displayed arterial hyperenhancement and 55 (78.5%) lesions showed hypoenhancement in portal venous and late phase (PVLP). Homogeneous and complete hyperenhancement pattern during the arterial phase is highly suspicious for HCC in liver cirrhosis (96.8%). Arterial isoenhancement and early washout during PVLP are characteristic for metastasis (73.3%). For recurrence lesions, arterial hyperenhancement and isoenhancement during PVLP are more common (60%). Conclusion. CEUS may provide added diagnostic values in FLLs appearing indistinctive on BMUS. Presence of early arterial enhancement and washout during PVLP may be helpful for detection of those lesions.

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“…Benign lesions are very common in the liver, and even in patients with primary malignancy, benign lesions unrelated to the known malignancy can be found in nearly 30% of patients [2]. Common benign liver masses include cysts, hemangiomas, and focal nodular hyperplasia (FNH).…”

Section: Summary Of Literature Review Introduction/backgroundmentioning

confidence: 99%

ACR Appropriateness Criteria® Liver Lesion-Initial Characterization

Imaging¹,

Chernyak

Horowitz

et al. 2020

Journal of the American College of Radiology

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Incidental liver masses are commonly identified on imaging performed for other indications. Since the prevalence of benign focal liver lesions in adults is high, even in patients with primary malignancy, accurate characterization of incidentally detected lesions is of paramount clinical importance. This document reviews utilization of various imaging modalities for characterization of incidentally detected liver lesions, discussed in the context of several clinical scenarios. For each clinical scenario, a summary of current evidence supporting the use of a given diagnostic modality is reported.The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.

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Liver Contrast-Enhanced Ultrasound Improves Detection of Liver Metastases in Patients with Pancreatic or Periampullary Cancer

Cited by 9 publications

References 23 publications

Combination of CEUS and MRI for the diagnosis of periampullary space-occupying lesions: a retrospective analysis

Combination of CEUS and MRI for the diagnosis of periampullary space-occupying lesions: a retrospective analysis

Characterization of Focal Liver Lesions Indistinctive on B Mode Ultrasound: Benefits of Contrast-Enhanced Ultrasound

ACR Appropriateness Criteria® Liver Lesion-Initial Characterization

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