Liver damage in acute heliotrine poisoning. 1. The intracellular distribution of pyridine nucleotides

Abstract

SYNTHESIS OF L-ASCORBIC ACID 25 uronic amide and L-gulonic amide are not converted into L-ascorbic acid by the microsomes. 4. Reduced glutathione and some metal-binding agents enhance the microsomal synthesis of Lascorbic acid by stimulating the synthesis and not indirectly by protecting the synthesized ascorbic acid. 5. L-Gulonolactone and L-xylohexulonolactone have been identified as the intermediates in the conversion of D-glucuronolactone into L-ascorbic acid in the presence of cyanide by the soluble enzyme preparations from the liver of rat and goat. 6. Both D-glucuronolactone reductase and Lgulonolactone oxidase are absent from the tissues of the primates, guinea pig, Indian fruit bat and red-vented bulbul-species which cannot synthesize ascorbic acid. Our best thanks are due to Professor M. Ishidate, Tokyo, for gifts of ethyl D-glucuronate and D-glucuronic amide, and to the Indian Council of Medical Research for financing this work.

Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity

“…The aqueous and ethanolic extracts of the whole plant exhibited cumulative toxic effects on the kidney, liver, and lungs on prolonged use [ 82 , 101 ]. Heliotrine is evident to cause liver damage in experimental animals [ 109 ], while lasiocarpine developed malignant tumors in rats [ 110 ]. Retrorsine exerted a toxic effect on human embryo liver cells [ 111 ].…”