Liver Damage in Obese Patients

Abstract

In morbidly obese patients, the incidence of histological liver damage is very high, despite acceptable liver function tests. In addition to steatosis, however, a "second hit" to induce necrosis and inflammation, favoring the development of significant fibrosis, is not essential. Being obese is an independent risk factor for liver damage and could contribute to liver fibrosis either alone or in association with other insulting factors. The identification of obese patients with septal fibrosis/cirrhosis, at surgery, is of considerable interest in clinical practice, mainly under the aspect of prognosis and liability.

Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet

“…Although the pathogenesis of NAFLD remains poorly understood, NAFLD is strongly associated with metabolic syndrome, a wellestablished clinical constellation of central obesity, type-2 diabetes mellitus, arterial hypertension, and dyslipidemia [2,[19][20][21]. The strong association of obesity with NAFLD suggests that obesity contributes to the pathogenesis of liver injury by steatosis and progression to steatohepatitis [2,20,22,23]. The prevalence of NAFLD and non-alcoholic steatohepatitis (NASH) in obese patients ranges from 69-100% to 25-30% of cases, respectively [24][25][26].…”

Exploring the Relationship of Drugs/Dietary Factors/Obesity in Occurence of Nonalcoholic Fatty Liver Disease

“…This study discussed the correlation of risk factors like dietary composition, medications & BMI in association with NAFLD.NAFLD was diagnosed in patients who initially came to medical attention by the incidental findings of increased liver echogenecity during ultrasonography done for master health checkup &other reasons. Ultrasonography could be used as aeconomical, non-invasive predictor of liver histology inmild, moderate and severe steatosis with acceptable sensitivity and specificity (10,11) . 67(84.8%) patients of our study population shown to have Grade I (mild) fatty changes of liver in ultrasonography.…”

Nonalcoholic fatty liver disease in a district general hospital: clinical presentation and risk factors

“…Up to 75% of patients with type II diabetes mellitus and over 50% of patients with a history of myocardial infarct have NAFLD [31,42,43]. Many patients undergoing bariatric surgery will also have NAFLD [44][45][46]. With the rapidly increasing prevalence of obesity and diabetes [13,15], the overall number of patients who will develop NAFLD will only increase.…”