1949
DOI: 10.1136/bmj.2.4635.1001
|View full text |Cite
|
Sign up to set email alerts
|

Liver Damage Produced by Feeding Alcohol or Sugar and its Prevention by Choline

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
69
0
1

Year Published

1952
1952
2009
2009

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 270 publications
(71 citation statements)
references
References 6 publications
1
69
0
1
Order By: Relevance
“…It (4,25). These experiments led to two concepts regarding pathogenesis: either that the fatty liver is due to dietary deficiencies associated with the caloric load of ethanol rather than to ethanol itself (4) or that the effect of dietary deficiencies is potentiated by alcohol, through enhancement of choline requirements independent of the increase in caloric intake (25).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It (4,25). These experiments led to two concepts regarding pathogenesis: either that the fatty liver is due to dietary deficiencies associated with the caloric load of ethanol rather than to ethanol itself (4) or that the effect of dietary deficiencies is potentiated by alcohol, through enhancement of choline requirements independent of the increase in caloric intake (25).…”
Section: Discussionmentioning
confidence: 99%
“…Among the problems at issue is the question of whether the fatty liver observed after prolonged alcohol intake is due only to nutritional deficiencies associated with alcoholism or whether it is caused by alcohol itself (4)(5)(6).…”
mentioning
confidence: 99%
“…As it is known, the long lasted debate whether nutritional deficiencies associated to alcoholism are responsible of liver injury [15,49] or whether ethanol per se (or some proximal metabolite) exerts toxic effects on hepatic cell has been largely resolved by the introduction of a novel model for experimental studies based on liquid diets in which ethanol (36% of total calories) replaces in a isocaloric way part of carbohydrates. With these diets, considered nutritionally adequate, the alcohol assumption in the rat was greatly increased and hepatic lesions (hepatic steatosis) were obtained in both rats and humans [76,77].…”
Section: Acetaldehyde Metabolismmentioning
confidence: 99%
“…The extract of liver lipid was evaporated and quantitatively transferred to a 2-g silicic acid4 column in ethyl ether. Triglyceride without phospholipid was completely eluted with 30 ml of diethyl 2 Purchased from New England Nuclear Corporation, Boston, Mass., as palmitic-9, 10-'H acid, specific activity 315 mc per mmole. 3 Purchased from New England Nuclear Corporation as palmitic-1-"C acid, specific activity 23.5 mc per mmole.…”
Section: B) Chemical Assaysmentioning
confidence: 99%