Liver Devascularisation in Pig: Alterations of Coagulation & Ebrinolys

Abstract

All arteries leading to the liver were ligated and an end-to-side portacaval shunt was performed in twelve pigs. Before and 1,3,6 and 9 hrs after the laparatomy a blood sample was drawn by femoral artherial catheter. APTT, Prothrombin, Factor VIII AHF(one-stage method), platelet and red cells counts, fast-acting Antiplasmin by S-2251, AT III by S-2238 were performed on each sample. Prothrombin slowly but progressively decreased while APTT reduced. VIII AHF showed a little increase at first but the higher level, about the 160% of initial value, was recorded at the 9th hr.AT III increased during the 1st hr but, as Antiplasmin, slowly decreased to the 70% in the following, hours. The AT III and the first VIII AHF increase occurred during portal, vi na clumping, simultaneously to a very deep fall of blood pressure. The cases of portal system and an adrenergic stress may explain this finding. The survival of the pigs was quite costant, more than 24 hrs: this model of hepatitis failure has been chosen for application of articial devices to support liver function.