Liver Disease in Hyperthyroidism

Ashkar, F S; Miller, R R; Smoak, William M.; Gilson, Albert J.

doi:10.1097/00007611-197104000-00016

Cited by 37 publications

(18 citation statements)

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“…These could be listed as increase in bromsulphalein retention, decrease in albumin, increase in bilirubin, ALT, AST, ALP and GGT (3,4,23). Many liver LBT deteriorations have been reported in hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

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Effect of hyperthyroidism and propylthiouracil treatment on liver biochemical tests

Aydemır

Bayraktaroğlu

Demircan

et al. 2005

International Journal of Clinical Practice

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Liver biochemical test (LBT) changes can be commonly observed in hyperthyroid patients. Those kinds of changes could also be observed because of propylthiouracil (PTU) therapy. We prospectively evaluated LBT changes because of PTU use for 1 year in patients who had been diagnosed with hyperthyroidism first. We studied 64 patients who had been diagnosed with hyperthyroidism. These patients took at least 1-year PTU treatment. We analysed LBT at diagnosis and after 2 and 12 months of treatment with PTU. Prior to PTU treatment, 30 (46.8%) of the 64 patients had at least one LBT abnormality. We observed at least one LBT abnormality in 11 (32%) patients after 2 months and nine (26%) patients after 12 months of treatment with PTU in 34 patients whose CBT were normal before treatment. We did not observe any deterioration in clinical picture and bilirubin levels. Elevated serum LBT during the pretreatment and PTU treatment period is common and usually transient and asymptomatic. PTU could be used for long times by lowering the dose and close follow-up in patients who have elevated LBT during the pretreatment and after PTU treatment period.

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Section: Discussionmentioning

confidence: 99%

“…The studies published in literature revealed that 15-76% patients with hyperthyroidism had elevations at least in one of LBT (3,9,(23)(24)(25)(26)(27)(28)(29)(30). The studies published in literature revealed that 15-76% patients with hyperthyroidism had elevations at least in one of LBT (3,9,(23)(24)(25)(26)(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Effect of hyperthyroidism and propylthiouracil treatment on liver biochemical tests

Aydemır

Bayraktaroğlu

Demircan

et al. 2005

International Journal of Clinical Practice

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“…However, it is also necessary to consider other multiple factors involved in this particular case of liver dysfunction. There are five possibilities for mechanisms of inducing liver dysfunction with hyperthyroidism: malnutrition, CHF, infection, the direct toxic effect of thyroid hormone and hepatic anoxia [12,13]. Firstly, regarding malnutrition, the blood test in the previous hospital showed albumin at 3.1 g/ dL and total cholesterol at 107 mg/dL.…”

Section: Discussionmentioning

confidence: 99%

“…While the blood test in our hospital also showed low albumin level, triglyceride and total cholesterol. These demonstrate chronic malnutrition, but the mechanisms remain unclear [12,[14][15][16]. Secondly, CHF had already presented on admission at the previous hospital.…”

Section: Discussionmentioning

confidence: 99%

A Case of Graves’ Disease Complicated With Thyroid Storm and Acute Hepatic Failure

Watanabe

2014

J Med Cases

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A 44-year-old man was transferred to our hospital because of deterioration of liver function. He was diagnosed as having Graves' disease, congestive heart failure and cholestatic liver failure, and started treatment with oral iodine, thiamazole, diuretics and β-blockers. The patient's condition was complicated with thyroid storm and spontaneous bacterial peritonitis (SBP). But the treatment for Graves' disease and SBP quickly cured the thyroid storm. Along with the improvement of the hyperthyroidism, the liver function also improved rapidly. We experienced a case of liver dysfunction that was caused by not treating Graves' disease. The present case suggested the importance of including Graves' disease in the differential diagnoses in cases of liver dysfunction.

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“…In one study retention of sulphobromophthalein was abnormal in 8°0 of patients, and abnormalities in bilirubin and alanine aminotransferase values also were observed, but less frequently. 3 There is little evidence to suggest that hypothyroidism affects liver function, but these patients will subsequently receive levothyroxine replacement therapy. As a result many will have raised plasma total and free thyroxine (T4) concentrations with normal total and free triiodothyronine (T3) concentrations.…”

Section: Introductionmentioning

confidence: 99%

Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage.

Beckett¹,

Kellett²,

Gow³

et al. 1985

BMJ

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Using plasma glutathione S-transferase measurements hepatocellular integrity was assessed in groups of hyperthyroid and hypothyroid patients before and after treatment.Ten of 14 hyperthyroid patients had clearly raised plasma glutathione S-transferase values at presentation and in each patient treatment with either iodine-131 or carbimazole resulted in a significant fall in glutathione S-transferase. The eight hypothyroid patients had normal glutathione S-transferase values at presentation and all showed a significant increase in these after thyroxine replacement therapy. In three of these patients in whom standard doses of replacement therapy were associated with a raised free thyroxine (T4) concentration but normal total and free triiodothyronine (T3) values glutathione S-transferase was increased. Similar though less consistent changes were seen in the results of standard chemical tests of liver function.It is concluded that hyperthyroidism may produce subclinical liver damage in a high proportion of patients and that this resolves with effective treatment. More important, the data suggest that hypothyroid patients receiving thyroxine replacement therapy may have similar subclinical liver damage.Patients receiving thyroxine should be monitored by the measurement of free, not total hormone concentra-

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Liver Disease in Hyperthyroidism

Cited by 37 publications

References 0 publications

Effect of hyperthyroidism and propylthiouracil treatment on liver biochemical tests

Effect of hyperthyroidism and propylthiouracil treatment on liver biochemical tests

A Case of Graves’ Disease Complicated With Thyroid Storm and Acute Hepatic Failure

Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage.

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