Liver disease mortality trends: a response to the editor

Angus, Colin; Meier, Petra; Holmes, John

doi:10.1016/s0140-6736(18)30497-5

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Patogênese E Epidemiologia Das Doenças Hepáticas1

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2023

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Cited by 2 publications

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“…Estima-se aproximadamente 60 milhões de pacientes cirróticos apenas nos Estados Unidos e União Europeia. Calcula-se que 2% das mortes no mundo estão associadas com diagnóstico clínico de cirrose hepática (Angus et al, 2018). Por outro lado, estima-se que a esteatose hepática não alcoólica afeta mais de 25% da população mundial, sendo um dos fatores de risco para o desenvolvimento da cirrose hepática (Rowe, 2017).…”

Section: Patogênese E Epidemiologia Das Doenças Hepáticasunclassified

Engenharia tecidual hepática utilizando células tronco pluripotentes induzidas

Guimarães¹

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Section: Patogênese E Epidemiologia Das Doenças Hepáticasunclassified

Engenharia tecidual hepática utilizando células tronco pluripotentes induzidas

Guimarães¹

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Pharmacological Benefits and Underlying Mechanisms of Salvia miltiorrhiza against Molecular Pathology of Various Liver Diseases: A Review

Hwang,

Jang,

Lee

2023

Am. J. Chin. Med.

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Salvia miltiorrhiza Bunge, called Danshen in Chinese, is the dried root and rhizome of S. miltiorrhiza, which is part of the mint family, Lamiaceae; it has chiefly been used to treat blood stasis and improve blood flow in cerebrovascular and cardiovascular diseases for over 2000 years. Recent preclinical studies have indicated that S. miltiorrhiza has a wide range of pharmacological properties making it useful for the treatment of diverse liver diseases. S. miltiorrhiza protects the liver from harmful hepatotoxins, reduces hepatic oxidative stress, ameliorates steatosis, and alleviates hepatic inflammation, fibrosis, and cancer. Moreover, several key mechanisms, including apoptosis, AMP-activated protein kinase, mitogen-activated protein kinase, and nuclear factor kappa B, may be involved in the benefits of S. miltiorrhiza in hepatic disorders. In particular, salvianolic acid B and cryptotanshinone, both compounds derived from S. miltiorrhiza, possess therapeutic activities similar to those of S. miltiorrhiza, and thus may play a crucial role in the therapeutic activity of S. miltiorrhiza in liver diseases. Because reports on the pharmacological effects of this herb are scattered, this review aimed to consolidate the available literature to allow the re-evaluation and identification of gaps to guide future research. This review focuses on the role of S. miltiorrhiza in improving the molecular pathology of liver diseases, as reported in in vitro and in vivo studies.

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Liver disease mortality trends: a response to the editor

Cited by 2 publications

References 5 publications

Engenharia tecidual hepática utilizando células tronco pluripotentes induzidas

Engenharia tecidual hepática utilizando células tronco pluripotentes induzidas

Pharmacological Benefits and Underlying Mechanisms of Salvia miltiorrhiza against Molecular Pathology of Various Liver Diseases: A Review

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