Liver Disease Secondary to Tetrachloroethylene Exposure

Meckler, Lowell C.

doi:10.1001/jama.1966.03110080102037

Cited by 24 publications

(4 citation statements)

References 4 publications

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“…Meckler et al (13) reported hepatocellular injury detected by liver biopsy in a woman with acute hepatitis after exposure to PCE. Bagnell et al (14) reported a case of an infant presenting with obstructive jaundice and hepatomegaly due to PCE exposure via breast milk.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure Associated with Occupational Exposure to Tetrachloroethylene

et al. 2011

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Tetrachloroethylene is a chlorinated solvent that is primarily used in dry cleaning and degreasing operations. Although the hepatotoxicity caused by tetrachloroethylene has been well documented in literature, it is rarely considered as a cause of acute liver failure. We report a case of a 39-yr-old man who was admitted to our hospital for acute liver failure due to tetrachloroethylene exposure. Histological examination of the liver revealed massive hepatic necrosis, prominently, in zone 3 of the hepatic lobules. The patient underwent supportive treatment along with 3 sessions of plasmapheresis, and consequently, he presented a favorable outcome. Repeat liver biopsy performed 6 months after the patient's discharge showed architectural distortion with postnecrotic cirrhosis. Physicians should be aware of the possibility of acute liver failure induced by tetrachloroethylene. Early plasmapheresis can be effective for individuals with sufficient capacity for hepatocyte regeneration.

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Section: Discussionmentioning

confidence: 99%

Acute Liver Failure Associated with Occupational Exposure to Tetrachloroethylene

et al. 2011

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“…[46,47,57], Alterationen der Atemwege und Lungen mit Atemnot, Husten und Hä-moptoe [59,63]. Zwischen dem Auftreten der ersten zentralnervösen Erscheinungen und dem Sichtbarwerden von Leberstörungen können einige Tage vergehen [43,62]. Auch können Leberstörungen ganz fehlen [47,49] …”

Section: Erfahrungen Beim Menschenunclassified

Tetrachlorethylen H [MAK Value Documentation in German language, 1974]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 3. Lieferung, Ausgabe 1974 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Inhalation Andere Applikationsarten Begründung des MAK‐Wertes

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“…Currently available information on hepatic injury due to environmental agents is briefly reviewed and comprises solvents and degreasing agents, pesd-* Dedicated to Professor Dr. Hans J. Dengler on the occasion of his 60th birthday cides, polyhalogenated biphenyls, dioxins and dibenzofuranes, epoxy resin hardeners, vinyl chloride, naturally occurring hepatotoxins in plants and fungi, herbal medicines and traditional remedies and a side-light on the Reye syndrom and the Spanish "toxic oil syndrome". [15,49,51,70,78,86,93,136]. Die hepatische Bioaktivierung ist bei dieser Substanzklasse besonders intensiv untersucht worden.…”

Section: Liver and Environmental Toxinsmentioning

confidence: 99%

Leber und Umweltgifte

1985

Klin Wochenschr

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For almost a century now numerous examples of acute and subacute hepatic injury from exposure to toxic agents in the occupational or non-occupational environment have been extensively studied and are well documented, but such events are comparatively rare. In contrast, epidemiological data associating exposure to environmental chemicals with chronic liver disease or primary hepatic malignancies in the human is scarce as compared with the vast body of literature concerning chronic pulmonary disease as a consequence of exposure at the workplace. Large-scale industrial production of many newly synthesized organic chemicals began during the period 1930-1940 but it was not until the 1960s that the output increased exponentially. Consequently, the spectrum of environmental influences is gaining increasing complexity since simultaneous or sequential exposure to a variety of pollutants is becoming the rule rather than the exception. Possible interaction or synergism of environmental agents--even of those which in themselves or for their low dosage level may be considered "harmless" - and particularly latency periods of more than one decade further complicate preventive strategies. The liver, as the central site for the biotransformation of xenobiotics, deserves special attention when new chemicals which are to be introduced into the environment are being tested for their potential toxicity, especially since many hepatotoxic agents have been shown to undergo bioactivation in the liver. Currently available information on hepatic injury due to environmental agents is briefly reviewed and comprises solvents and degreasing agents, pesticides, polyhalogenated biphenyls, dioxins and dibenzofuranes, epoxy resin hardeners, vinyl chloride, naturally occurring hepatotoxins in plants and fungi, herbal medicines and traditional remedies and a side-light on the Reye syndrome and the Spanish "toxic oil syndrome".

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Liver Disease Secondary to Tetrachloroethylene Exposure

Cited by 24 publications

References 4 publications

Acute Liver Failure Associated with Occupational Exposure to Tetrachloroethylene

Acute Liver Failure Associated with Occupational Exposure to Tetrachloroethylene

Tetrachlorethylen H [MAK Value Documentation in German language, 1974]

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