Liver Dysfunction in Late Pregnancy: Cytomegalovirus‐Induced Hepatitis or the HELLP Syndrome?

Ohkuchi, Akihide; Minakami, Hisanori; Suzuki, I; Ayustawati,; Izumi, Akio; Sato, Ikuo

doi:10.1111/j.1447-0756.2001.tb01279.x

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…4 HELLPs antigens by suppressing cell-mediated immunity, which may induce a state of increased susceptibility to intracellular pathogen reactivation, such as CMV. 11 Previously, CMV infection was reported in either preeclampsia or HELLPs cases 12,13 and has been reported to initiate Toll-like receptor (TLR) signaling. 14 In CMV-seropositive persons, the monocyte appears to be the major cell type harboring the virus in blood, presumably in a latent state.…”

Section: Introductionmentioning

confidence: 99%

CMV Infection, TLR‐2 and ‐4 Expression, and Cytokine Profiles in Early‐Onset Preeclampsia with HELLP Syndrome

Xie

Dadelszen

Nadeau

2014

American J Rep Immunol

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Problem Cytomegalovirus (CMV) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll-like receptor (TLR) expression in early onset preeclampsia (EOPE) with Hemolysis, Elevated Liver enzyme and Low Platelets syndrome (HELLPs) are unexplored. Method of study A case-control study was performed to examine maternal CMV antibodies, neutrophil Toll like receptor (TLR)-2 and -4 expression as well as the cytokine profile in EOPE with HELLPs (EOPE-HELLPs) (n=10), late onset preeclampsia (LOPE) (n=20), normal pregnancy (n=60), and non-pregnancy (n=20) controls. Results EOPE-HELLPs had significantly increased CMV IgG sero-positivity, up-regulated TLR-2/-4 mRNA expression, elevated serum IL-6 and TNF-α, and reduced IL-10 compared with matched normal and non-pregnancy controls. No significant difference was observed between LOPE and normal pregnancy controls. Conclusion We observed a significant association of CMV infection and innate immune response in EOPE-HELLPs. Our data suggest CMV infection may be a risk factor for this disorder.

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Section: Introductionmentioning

confidence: 99%

CMV Infection, TLR‐2 and ‐4 Expression, and Cytokine Profiles in Early‐Onset Preeclampsia with HELLP Syndrome

Xie

Dadelszen

Nadeau

2014

American J Rep Immunol

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“…Chan et al [45] reported a case of biopsy-proven CMV hepatitis in a patient receiving prednisone and azathioprine. CMVinduced hepatitis occurs on occasion during pregnancy and the presentation can be similar to the variant of pre-eclampsia known as the HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) [46]. Fetal infection with CMV is a well-known cause of congenital abnormalities, although CMV-induced hepatitis is an uncommon infection of nonimmunosuppressed neonates [47,48].…”

Section: Tissue-invasive Cytomegalovirus Disease Of Other Gastrointesmentioning

confidence: 98%

Gastrointestinal infections caused by cytomegalovirus

Bobak

2003

Curr Infect Dis Rep

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Cytomegalovirus (CMV) is an important human pathogen, causing a variety of syndromes ranging from asymptomatic infections to life-threatening end-organ disease. Infections of the gastrointestinal tract are an especially common form of disease caused by CMV and are usually manifest as luminal infections, such as esophagitis or colitis. Solid organ disease caused by CMV is also known to occur, with hepatitis being the most common syndrome. The large majority of cases of tissue-invasive disease caused by CMV have been reported to occur in immunocompromised hosts. Patients at highest risk for serious CMV-mediated disease are commonly HIV infected, recipients of transplants, or are receiving potent immunosuppressive medications. Intriguingly, several recent reports have discussed the previously underappreciated role of serious forms of CMV-mediated disease occurring in immunocompetent patients. This paper reviews several recent reports addressing important aspects related to the diagnosis, treatment, and management of CMV infections of the gastrointestinal tract.

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“…En cas d'atteinte hépatique, l'ictère est peu fréquent, alors que l'hépa-tomégalie est souvent retrouvée [42]. Ces hépatites peuvent être très sévères au cours de la grossesse et mimer des tableaux de HELLP syndrome [43].…”

Section: Hépatite Due Au Cytomégalovirus (Cmv)unclassified

Hépatites virales aiguës à Herpesviridae et grossesse : mise au point

Dochez

Ducarme

2015

La Presse Médicale

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Liver Dysfunction in Late Pregnancy: Cytomegalovirus‐Induced Hepatitis or the HELLP Syndrome?

Cited by 8 publications

References 15 publications

CMV Infection, TLR‐2 and ‐4 Expression, and Cytokine Profiles in Early‐Onset Preeclampsia with HELLP Syndrome

CMV Infection, TLR‐2 and ‐4 Expression, and Cytokine Profiles in Early‐Onset Preeclampsia with HELLP Syndrome

Gastrointestinal infections caused by cytomegalovirus

Hépatites virales aiguës à Herpesviridae et grossesse : mise au point

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