1992
DOI: 10.1002/hep.1840160137
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Liver Endocytosis and Kupffer Cells

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Cited by 115 publications
(59 citation statements)
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“…The ability of endothelial liver cells to recognize and internalize apoptotic bodies has already been reported (Dini et al, 1995;Dini & Carla, 1998) and is in line with the capacity of the hepatic sinusoidal wall to interact with particulate materials (Steffan et al, 1986;Dini et al, 1993) and to operate as a protective barrier for the systemic circulation by removing potentially harmful materials carried by portal blood flow (i.e., bacterial endotoxins, microrganisms, immune complexes, tumor cells and other antigens) (Toth & Thomas, 1992). The possible involvement of hepatic carbohydrate receptors in apoptotic cell clearance is indirectly supported by i) the fact that the cell surface of dead cells expresses modified glycoproteins (in particular great amounts of galactose/N-acetyl-galactosamine/mannose residues); ii) that endothelial cells express on their cell surfaces the carbohydrate receptor systems; iii) that when the cell surface expression of these receptors on HSE is increased by LPS andILIß, phagocytosis of apoptotic PBL is markedly enhanced.…”
Section: Discussionsupporting
confidence: 68%
“…The ability of endothelial liver cells to recognize and internalize apoptotic bodies has already been reported (Dini et al, 1995;Dini & Carla, 1998) and is in line with the capacity of the hepatic sinusoidal wall to interact with particulate materials (Steffan et al, 1986;Dini et al, 1993) and to operate as a protective barrier for the systemic circulation by removing potentially harmful materials carried by portal blood flow (i.e., bacterial endotoxins, microrganisms, immune complexes, tumor cells and other antigens) (Toth & Thomas, 1992). The possible involvement of hepatic carbohydrate receptors in apoptotic cell clearance is indirectly supported by i) the fact that the cell surface of dead cells expresses modified glycoproteins (in particular great amounts of galactose/N-acetyl-galactosamine/mannose residues); ii) that endothelial cells express on their cell surfaces the carbohydrate receptor systems; iii) that when the cell surface expression of these receptors on HSE is increased by LPS andILIß, phagocytosis of apoptotic PBL is markedly enhanced.…”
Section: Discussionsupporting
confidence: 68%
“…This binding to endothelial cells may be explained by the ability of endothelial cells to bind matrix molecules (34), but also by the presence of other protein removal systems (35). pCVI-HSA displayed only minor binding to Kupffer cells, the hepatic cell type involved in the removal of large molecular weight molecules and foreign particles (33). Therefore, although the total distribution of pCVI-HSA to normal and fibrotic rat livers is almost identical, the intrahepatic distribution is completely different.…”
Section: Discussionmentioning
confidence: 98%
“…Attachment of cyclic peptides to the lysine groups of albumin might result in conformational changes of the albumin backbone due to electrostatic interactions between the carrier and the attached peptide moiety or the reaction conditions used for the coupling of cyclic peptides to HSA may cause a denaturation or refolding of the albumin molecule. This may lead to immunogenic responses or nonspecific removal by Kupffer cells or other macrophages in vivo (33). The identical CD spectra of pCVI- HSA and HSA, however, indicated that the conformation of the albumin molecule was not affected by the introduction of the 10 C*GRGDSPC* groups to albumin.…”
Section: Discussionmentioning
confidence: 99%
“…Whatever the domains involved, CEA could promote the development of liver metastases through homotypic or heterotypic adhesion between carcinomas cells themselves or between carcinoma cells and CEA trapped at the surface of Kupffer cells (Toth et al, 1992;Jessup et al, 1993a). Using ten human colon carcinoma cell lines, Tibbetts et al (1993) demonstrated that there is a connection between membrane CEA expression and the development of experimental liver metastases following i.s.…”
Section: Discussionmentioning
confidence: 99%