Liver enhancement in healthy dogs after gadoxetic acid administration during dynamic contrast-enhanced magnetic resonance imaging

Borusewicz, Pola; Stańczyk, Ewa; Kubiak, Krzysztof; Spużak, Jolanta; Glińska-Suchocka, Kamila; Jankowski, Marcin; Nicpoń, Jakub; Podgórski, Przemysław

doi:10.1016/j.tvjl.2018.03.004

Cited by 5 publications

(4 citation statements)

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“…The data were recorded approximately 26 min after contrast administration. This is in accordance with own observations [15] and the observations of other authors, who suggest that post-contrast sequences should be obtained between 20 and 40 min after contrast administration [16].…”

Section: Discussionsupporting

confidence: 93%

Magnetic resonance imaging of liver tumors using gadoxetic acid (Gd-EOB-DTPA) - pilot study

et al. 2019

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Background Magnetic resonance imaging using gadoxetic acid, a hepatocyte-specific contrast agent, is one of the most useful MRI techniques used to diagnose liver tumours in humans. During the hepato-biliary phase, there is uptake of gadoxetic acid by normal hepatocytes, leading to hepatic parenchymal enhancement. This feature is used in human medicine to diagnose hepatic parenchymal metastatic disease, to differentiate primary liver tumours, to diagnose liver cirrhosis and focal nodular hyperplasia. This study presents the preliminary results of magnetic resonance imaging of focal lesions localised in the liver parenchyma in dogs following the administration of gadoxetic acid. Results The lesion enhancement ratio (ER lesion ) in the tumour metastasis was 0.05; the liver enhancement ratio (ER liver ) – 0.49 and the post-contrast lesion-to-liver contrast ratio (CR) was 0.17. In dogs with hepatocellular hyperplasia, these values were 0.54; 0.51; and 1.18, respectively. In two dogs with a hepatic adenoma, the ER lesion was 0.26 and 0.17, respectively; the ER liver was 0.47 and 0.47, respectively and the CR was 0.33 and 0.31, respectively. In the dog with a neuroendocrine tumour, the ER lesion was 0.03; the ER liver amounted to 0.58 and the CR was 0.35. In the case of a hepatocellular carcinoma, these coefficients were 0.2, 0.6 and 0.3, respectively. Conclusion Based on the results, it may be assumed that the MR images of the proliferative hepatic parenchymal lesions in dogs using gadoxetic acid are similar to those obtained in humans. This suggests that the contrast enhancement patterns used in human medicine may be useful in differentiating hepatic parenchymal lesions in dogs.

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Section: Discussionsupporting

confidence: 93%

Magnetic resonance imaging of liver tumors using gadoxetic acid (Gd-EOB-DTPA) - pilot study

et al. 2019

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“…In the present study, more than 80% of all neoplasms of the liver were located in the left medial or left lateral lobes. In the case of large formations in the right lobes, the tumor invades the caudal hollow vein, common bile duct, and pancreas, so the animal's condition is unsuitable for surgery and treatment is impractical [36,42,43]. Furthermore, priority on the left side of the liver can be caused by the anatomical feature of the liver's blood circulation.…”

Section: Discussionmentioning

confidence: 99%

Influence of hepatic neoplasia on life expectancy in dogs

et al. 2020

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Background and Aim: The present study investigated the influence of liver tumor structure on life expectancy in dogs. Diseases of the liver comprise 5-25% of all non-communicable diseases in dogs, and primary hepatic tumors account for 0.6-1.3% of tumors. This research aimed to study the post-operative life span of animals with primary or metastatic tumors of the liver. Materials and Methods: During the study period, 7124 oncological operations were performed in our clinic. In total, 128 liver tumors were detected in live animals, while 323 were detected posthumously. Forty animals underwent surgery for various liver tumors. In dogs with primary liver tumors, the average age was 11.9 years and the average body weight was 15.5 kg, while in dogs with liver metastases, the mean age was 11.4 years and the average body weight was 24 kg. Results: The ratio of males to females among dogs with primary liver tumors was about 1:1 (ten females and nine males), while that among dogs with metastatic liver damage was clearly predominantly female (14 females and two males) because females often undergo surgery for cancerous mammary glands or ovaries. Conclusion: The size of tumors and the number of affected lobes had a significant effect on the post-operative life span. With a tumor size of <5 cm and a lesion covering less than two lobes of the liver, life expectancy was significantly longer and the prognosis was more favorable. In cases of large tumors or those affecting more than two lobes, life expectancy was significantly reduced and the prognosis was cautious to unfavorable.

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“… 12 Another study described that SI of the hepatobiliary phase peaked at 26 minutes after administration of Gd-EOB-DTPA. 16 However, several reports showed that SI of the hepatobiliary phase reached the plateau at 20 minutes after administration of Gd-EOB-DTPA. 13 16 17 Therefore, we defined the hepatobiliary phase at 20 minutes after Gd-EOB-DTPA injection.…”

Section: Discussionmentioning

confidence: 99%

“…The uptake of Gd‐EOB‐DTPA by hepatocytes peaked at 10 minutes after administration of Gd‐EOB‐DTPA 12. Another study described that SI of the hepatobiliary phase peaked at 26 minutes after administration of Gd‐EOB‐DTPA 16. However, several reports showed that SI of the hepatobiliary phase reached the plateau at 20 minutes after administration of Gd‐EOB‐DTPA 13 16 17.…”

Section: Discussionmentioning

confidence: 99%

Assessment of hepatitis and fibrosis using Gd‐EOB‐DTPA MRI in dogs

Tanaka

Nishida

Mie

et al. 2020

Veterinary Record Open

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BackgroundGadoxetate sodium (Gd-EOB-DTPA) is taken into hepatocytes and excreted into the bile. Hepatocytes with reduced function or dysfunction due to hepatocellular carcinoma (HCC), hepatitis or hepatic fibrosis show impaired Gd-EOB-DTPA uptake. The purpose of the present retrospective case series was to assess the relationship between liver function and contrast enhancement using Gd-EOB-DTPA MRI.MethodsSixteen dogs with a histopathological diagnosis of liver disease, including six with HCC, three with nodular hyperplasia, two with hepatocellular adenoma, two with liver fibrosis and three with hepatitis were included in the study along with three dogs with suspected liver disease but no histopathological diagnosis of liver disease. Relative signal intensities (RSI) of the common bile duct and gall bladder were calculated, and their relationship with the following serum biochemical parameters was assessed: total bilirubin, alanine transaminase, alkaline phosphatase and albumin (Alb). To assess anatomical liver function, relative contrast enhancement indices (RCEI) of the liver were calculated, and differences were assessed between normal and diseased liver.ResultsRSI showed no significant differences between dogs without and with a histopathological diagnosis of liver disease (P=0.88) although they were significantly correlated with Alb (ρ=0.57, P=0.02) in dogs with a histopathological diagnosis of liver disease. RCEI was significantly higher in normal liver tissue than that in livers with hepatitis/fibrosis (P=0.048) and HCC (P=0.03) but not nodular hyperplasia/hepatocellular adenoma (P=0.51).ConclusionsGd-EOB-DTPA MRI may be potentially useful in the assessment of anatomical liver function in dogs with liver disease.

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Liver enhancement in healthy dogs after gadoxetic acid administration during dynamic contrast-enhanced magnetic resonance imaging

Cited by 5 publications

References 28 publications

Magnetic resonance imaging of liver tumors using gadoxetic acid (Gd-EOB-DTPA) - pilot study

Magnetic resonance imaging of liver tumors using gadoxetic acid (Gd-EOB-DTPA) - pilot study

Influence of hepatic neoplasia on life expectancy in dogs

Assessment of hepatitis and fibrosis using Gd‐EOB‐DTPA MRI in dogs

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